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Gene: HYI |
Gene summary for HYI |
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Gene information | Species | Human | Gene symbol | HYI | Gene ID | 81888 |
Gene name | hydroxypyruvate isomerase (putative) | |
Gene Alias | HT036 | |
Cytomap | 1p34.2 | |
Gene Type | protein-coding | GO ID | GO:0006081 | UniProtAcc | Q5T013 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81888 | HYI | P52T-E | Human | Esophagus | ESCC | 4.58e-28 | 5.05e-01 | 0.1555 |
81888 | HYI | P54T-E | Human | Esophagus | ESCC | 2.14e-36 | 7.74e-01 | 0.0975 |
81888 | HYI | P56T-E | Human | Esophagus | ESCC | 1.30e-06 | 1.05e+00 | 0.1613 |
81888 | HYI | P57T-E | Human | Esophagus | ESCC | 2.03e-44 | 8.89e-01 | 0.0926 |
81888 | HYI | P61T-E | Human | Esophagus | ESCC | 4.21e-15 | 1.89e-01 | 0.099 |
81888 | HYI | P62T-E | Human | Esophagus | ESCC | 4.44e-42 | 7.48e-01 | 0.1302 |
81888 | HYI | P65T-E | Human | Esophagus | ESCC | 7.14e-31 | 5.33e-01 | 0.0978 |
81888 | HYI | P74T-E | Human | Esophagus | ESCC | 1.70e-31 | 7.39e-01 | 0.1479 |
81888 | HYI | P75T-E | Human | Esophagus | ESCC | 2.29e-32 | 5.71e-01 | 0.1125 |
81888 | HYI | P76T-E | Human | Esophagus | ESCC | 9.79e-53 | 1.04e+00 | 0.1207 |
81888 | HYI | P79T-E | Human | Esophagus | ESCC | 6.97e-25 | 5.40e-01 | 0.1154 |
81888 | HYI | P80T-E | Human | Esophagus | ESCC | 1.03e-14 | 2.22e-01 | 0.155 |
81888 | HYI | P82T-E | Human | Esophagus | ESCC | 2.98e-18 | 9.90e-01 | 0.1072 |
81888 | HYI | P83T-E | Human | Esophagus | ESCC | 3.40e-10 | 4.64e-01 | 0.1738 |
81888 | HYI | P84T-E | Human | Esophagus | ESCC | 4.02e-07 | 2.07e-01 | 0.0933 |
81888 | HYI | P89T-E | Human | Esophagus | ESCC | 5.54e-12 | 1.30e+00 | 0.1752 |
81888 | HYI | P91T-E | Human | Esophagus | ESCC | 1.36e-08 | 1.17e+00 | 0.1828 |
81888 | HYI | P94T-E | Human | Esophagus | ESCC | 5.27e-06 | 1.02e+00 | 0.0879 |
81888 | HYI | P107T-E | Human | Esophagus | ESCC | 2.60e-25 | 7.10e-01 | 0.171 |
81888 | HYI | P126T-E | Human | Esophagus | ESCC | 5.11e-06 | 3.92e-01 | 0.1125 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00060818 | Esophagus | ESCC | cellular aldehyde metabolic process | 40/8552 | 60/18723 | 8.30e-04 | 4.28e-03 | 40 |
GO:00060815 | Liver | Cirrhotic | cellular aldehyde metabolic process | 28/4634 | 60/18723 | 1.83e-04 | 1.71e-03 | 28 |
GO:000608112 | Liver | HCC | cellular aldehyde metabolic process | 39/7958 | 60/18723 | 3.61e-04 | 2.50e-03 | 39 |
GO:00060817 | Oral cavity | OSCC | cellular aldehyde metabolic process | 36/7305 | 60/18723 | 7.94e-04 | 4.27e-03 | 36 |
GO:00060816 | Prostate | BPH | cellular aldehyde metabolic process | 20/3107 | 60/18723 | 1.14e-03 | 7.10e-03 | 20 |
GO:000608113 | Prostate | Tumor | cellular aldehyde metabolic process | 21/3246 | 60/18723 | 7.59e-04 | 5.20e-03 | 21 |
GO:00060819 | Skin | cSCC | cellular aldehyde metabolic process | 28/4864 | 60/18723 | 4.35e-04 | 3.36e-03 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa006306 | Esophagus | ESCC | Glyoxylate and dicarboxylate metabolism | 21/4205 | 30/8465 | 1.95e-02 | 4.35e-02 | 2.23e-02 | 21 |
hsa0063013 | Esophagus | ESCC | Glyoxylate and dicarboxylate metabolism | 21/4205 | 30/8465 | 1.95e-02 | 4.35e-02 | 2.23e-02 | 21 |
hsa006304 | Liver | Cirrhotic | Glyoxylate and dicarboxylate metabolism | 20/2530 | 30/8465 | 3.36e-05 | 2.54e-04 | 1.57e-04 | 20 |
hsa0063011 | Liver | Cirrhotic | Glyoxylate and dicarboxylate metabolism | 20/2530 | 30/8465 | 3.36e-05 | 2.54e-04 | 1.57e-04 | 20 |
hsa0063021 | Liver | HCC | Glyoxylate and dicarboxylate metabolism | 24/4020 | 30/8465 | 2.66e-04 | 1.24e-03 | 6.88e-04 | 24 |
hsa0063031 | Liver | HCC | Glyoxylate and dicarboxylate metabolism | 24/4020 | 30/8465 | 2.66e-04 | 1.24e-03 | 6.88e-04 | 24 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HYI | SNV | Missense_Mutation | novel | c.500N>G | p.Gln167Arg | p.Q167R | protein_coding | tolerated(0.2) | benign(0.007) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
HYI | SNV | Missense_Mutation | rs746723799 | c.320N>C | p.Val107Ala | p.V107A | protein_coding | deleterious(0.04) | benign(0) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HYI | SNV | Missense_Mutation | c.839N>T | p.Asp280Val | p.D280V | protein_coding | deleterious(0.04) | possibly_damaging(0.877) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
HYI | SNV | Missense_Mutation | novel | c.661A>G | p.Asn221Asp | p.N221D | protein_coding | tolerated(0.43) | benign(0.421) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
HYI | SNV | Missense_Mutation | c.210G>T | p.Glu70Asp | p.E70D | protein_coding | tolerated(0.48) | benign(0.019) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | ||
HYI | SNV | Missense_Mutation | rs201885225 | c.569N>T | p.Thr190Met | p.T190M | protein_coding | tolerated(0.06) | benign(0.26) | TCGA-BK-A13C-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HYI | SNV | Missense_Mutation | novel | c.749C>A | p.Pro250His | p.P250H | protein_coding | deleterious(0.04) | probably_damaging(0.914) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
HYI | SNV | Missense_Mutation | novel | c.824N>G | p.Tyr275Cys | p.Y275C | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
HYI | SNV | Missense_Mutation | novel | c.452A>T | p.Glu151Val | p.E151V | protein_coding | deleterious(0.05) | benign(0.248) | TCGA-G3-A7M6-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
HYI | SNV | Missense_Mutation | novel | c.586N>A | p.Ala196Thr | p.A196T | protein_coding | tolerated(0.06) | benign(0.139) | TCGA-CV-A6JZ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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