Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/HS3ST4_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/HS3ST4_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/HS3ST4_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/HS3ST4_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/HS3ST4_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HS3ST4 | SNV | Missense_Mutation | | c.1072N>A | p.Glu358Lys | p.E358K | Q9Y661 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-BH-A1F8-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
HS3ST4 | SNV | Missense_Mutation | novel | c.7N>T | p.Arg3Trp | p.R3W | Q9Y661 | protein_coding | deleterious_low_confidence(0) | benign(0.056) | TCGA-C8-A135-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
HS3ST4 | SNV | Missense_Mutation | | c.1069G>C | p.Gly357Arg | p.G357R | Q9Y661 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-C8-A1HJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HS3ST4 | SNV | Missense_Mutation | | c.896C>G | p.Thr299Arg | p.T299R | Q9Y661 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1JU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
HS3ST4 | SNV | Missense_Mutation | | c.1133A>C | p.Lys378Thr | p.K378T | Q9Y661 | protein_coding | deleterious(0.01) | benign(0.11) | TCGA-E9-A1RE-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
HS3ST4 | SNV | Missense_Mutation | novel | c.515C>T | p.Ala172Val | p.A172V | Q9Y661 | protein_coding | tolerated_low_confidence(0.12) | benign(0.073) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
HS3ST4 | SNV | Missense_Mutation | novel | c.514G>A | p.Ala172Thr | p.A172T | Q9Y661 | protein_coding | tolerated_low_confidence(0.14) | benign(0.011) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HS3ST4 | SNV | Missense_Mutation | | c.1147N>C | p.Glu383Gln | p.E383Q | Q9Y661 | protein_coding | tolerated(0.09) | benign(0.372) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HS3ST4 | SNV | Missense_Mutation | | c.1338T>G | p.Asp446Glu | p.D446E | Q9Y661 | protein_coding | deleterious(0) | benign(0.324) | TCGA-A6-3810-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HS3ST4 | SNV | Missense_Mutation | rs753467285 | c.1244N>A | p.Arg415Gln | p.R415Q | Q9Y661 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |