Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: HOXA10

Gene summary for HOXA10

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

HOXA10

Gene ID

3206

Gene namehomeobox A10
Gene AliasHOX1
Cytomap7p15.2
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

P31260


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
3206HOXA10GSM6177621_NYU_UCEC2_lib1_lib1HumanEndometriumEEC1.87e-14-2.82e-01-0.1934
3206HOXA10GSM6177622_NYU_UCEC3_lib1_lib1HumanEndometriumEEC1.16e-36-7.08e-01-0.1917
3206HOXA10GSM6177622_NYU_UCEC3_lib2_lib2HumanEndometriumEEC4.50e-40-6.78e-01-0.1916
3206HOXA10GSM6177623_NYU_UCEC3_VisHumanEndometriumEEC4.16e-09-4.86e-01-0.1269
3206HOXA10LZE4THumanEsophagusESCC5.04e-062.04e-010.0811
3206HOXA10LZE5THumanEsophagusESCC6.93e-032.14e-010.0514
3206HOXA10LZE20THumanEsophagusESCC1.14e-031.67e-010.0662
3206HOXA10LZE22THumanEsophagusESCC4.19e-095.30e-010.068
3206HOXA10LZE24THumanEsophagusESCC2.10e-092.71e-010.0596
3206HOXA10LZE21THumanEsophagusESCC4.05e-022.91e-010.0655
3206HOXA10P2T-EHumanEsophagusESCC1.02e-315.07e-010.1177
3206HOXA10P4T-EHumanEsophagusESCC3.97e-306.26e-010.1323
3206HOXA10P5T-EHumanEsophagusESCC9.44e-071.32e-010.1327
3206HOXA10P8T-EHumanEsophagusESCC7.28e-264.70e-010.0889
3206HOXA10P9T-EHumanEsophagusESCC1.96e-123.06e-010.1131
3206HOXA10P10T-EHumanEsophagusESCC6.38e-314.93e-010.116
3206HOXA10P11T-EHumanEsophagusESCC1.22e-043.54e-010.1426
3206HOXA10P12T-EHumanEsophagusESCC3.95e-304.90e-010.1122
3206HOXA10P15T-EHumanEsophagusESCC1.96e-051.44e-010.1149
3206HOXA10P16T-EHumanEsophagusESCC1.00e-244.37e-010.1153
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0061458ColorectumADreproductive system development116/3918427/187231.11e-031.01e-02116
GO:0048608ColorectumADreproductive structure development114/3918424/187231.78e-031.47e-02114
GO:0048736ColorectumADappendage development51/3918172/187234.20e-032.89e-0251
GO:0060173ColorectumADlimb development51/3918172/187234.20e-032.89e-0251
GO:00487361ColorectumSERappendage development42/2897172/187231.43e-031.55e-0242
GO:00601731ColorectumSERlimb development42/2897172/187231.43e-031.55e-0242
GO:00614581ColorectumSERreproductive system development87/2897427/187233.69e-033.07e-0287
GO:0035107ColorectumSERappendage morphogenesis33/2897138/187236.10e-034.42e-0233
GO:0035108ColorectumSERlimb morphogenesis33/2897138/187236.10e-034.42e-0233
GO:00486081ColorectumSERreproductive structure development85/2897424/187236.33e-034.56e-0285
GO:00614582ColorectumMSSreproductive system development115/3467427/187239.86e-062.39e-04115
GO:00486082ColorectumMSSreproductive structure development113/3467424/187231.94e-054.18e-04113
GO:00487362ColorectumMSSappendage development48/3467172/187231.61e-031.46e-0248
GO:00601732ColorectumMSSlimb development48/3467172/187231.61e-031.46e-0248
GO:00614589EndometriumAEHreproductive system development88/2100427/187239.50e-096.41e-0788
GO:00486089EndometriumAEHreproductive structure development87/2100424/187231.43e-089.12e-0787
GO:00351073EndometriumAEHappendage morphogenesis29/2100138/187236.06e-045.94e-0329
GO:00351083EndometriumAEHlimb morphogenesis29/2100138/187236.06e-045.94e-0329
GO:00487366EndometriumAEHappendage development33/2100172/187231.41e-031.18e-0233
GO:00601736EndometriumAEHlimb development33/2100172/187231.41e-031.18e-0233
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa052028EsophagusESCCTranscriptional misregulation in cancer116/4205193/84652.08e-035.95e-033.05e-03116
hsa0520213EsophagusESCCTranscriptional misregulation in cancer116/4205193/84652.08e-035.95e-033.05e-03116
hsa0520221ProstateTumorTranscriptional misregulation in cancer59/1791193/84651.22e-035.26e-033.26e-0359
hsa0520231ProstateTumorTranscriptional misregulation in cancer59/1791193/84651.22e-035.26e-033.26e-0359
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
HOXA10INCAFBreastDCISASPN,IL15RA,BNC2, etc.9.71e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HOXA10ECMBreastHealthyASPN,IL15RA,BNC2, etc.3.40e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HOXA10INCAFBreastHealthyASPN,IL15RA,BNC2, etc.1.32e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HOXA10INCAFBreastIDCASPN,IL15RA,BNC2, etc.5.49e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HOXA10INCAFEndometriumADJHOXA11,SFRP4,COL1A1, etc.6.29e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HOXA10INCAFEndometriumAEHHOXA11,SFRP4,COL1A1, etc.5.96e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HOXA10INCAFEndometriumEECHOXA11,SFRP4,COL1A1, etc.4.18e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HOXA10FIBEndometriumEECHOXA11,SFRP4,COL1A1, etc.3.61e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HOXA10INCAFEndometriumHealthyHOXA11,SFRP4,COL1A1, etc.5.22e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HOXA10MDSCsEsophagusESCCNDUFAF6,PHF1,DYRK4, etc.1.16e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
HOXA10insertionFrame_Shift_Insnovelc.974_975insCAAATp.Glu325AspfsTer3p.E325Dfs*3P31260protein_codingTCGA-AN-A0AK-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
HOXA10SNVMissense_Mutationnovelc.77C>Tp.Ala26Valp.A26VP31260protein_codingdeleterious(0.01)probably_damaging(0.949)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
HOXA10SNVMissense_Mutationnovelc.617N>Ap.Ser206Asnp.S206NP31260protein_codingtolerated(0.51)benign(0)TCGA-C5-A902-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinSD
HOXA10SNVMissense_Mutationnovelc.1048G>Ap.Glu350Lysp.E350KP31260protein_codingdeleterious(0)probably_damaging(1)TCGA-VS-A9UU-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
HOXA10SNVMissense_Mutationnovelc.498G>Tp.Glu166Aspp.E166DP31260protein_codingdeleterious(0)probably_damaging(0.987)TCGA-CA-6717-01Colorectumcolon adenocarcinomaMale<65I/IIChemotherapyoxaliplatinCR
HOXA10SNVMissense_Mutationc.1174N>Cp.Lys392Glnp.K392QP31260protein_codingdeleterious(0)probably_damaging(1)TCGA-CK-6746-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
HOXA10SNVMissense_Mutationnovelc.1186C>Gp.Arg396Glyp.R396GP31260protein_codingdeleterious(0)probably_damaging(0.995)TCGA-A5-A0G1-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
HOXA10SNVMissense_Mutationnovelc.1094G>Ap.Arg365Glnp.R365QP31260protein_codingdeleterious(0)probably_damaging(1)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
HOXA10SNVMissense_Mutationc.1079A>Gp.Tyr360Cysp.Y360CP31260protein_codingdeleterious(0)probably_damaging(1)TCGA-AP-A051-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
HOXA10SNVMissense_Mutationnovelc.1176N>Tp.Lys392Asnp.K392NP31260protein_codingdeleterious(0)probably_damaging(1)TCGA-AP-A1DV-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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