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Gene: HNRNPF |
Gene summary for HNRNPF |
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Gene information | Species | Human | Gene symbol | HNRNPF | Gene ID | 3185 |
Gene name | heterogeneous nuclear ribonucleoprotein F | |
Gene Alias | HNRPF | |
Cytomap | 10q11.21 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | A0A024R7T3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3185 | HNRNPF | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.24e-18 | 8.15e-01 | 0.294 |
3185 | HNRNPF | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 5.27e-08 | 1.34e+00 | 0.3487 |
3185 | HNRNPF | HTA11_99999965104_69814 | Human | Colorectum | MSS | 9.39e-17 | 8.87e-01 | 0.281 |
3185 | HNRNPF | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.48e-31 | 1.07e+00 | 0.3859 |
3185 | HNRNPF | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.34e-04 | 3.38e-01 | 0.3005 |
3185 | HNRNPF | A015-C-203 | Human | Colorectum | FAP | 1.22e-03 | -1.76e-01 | -0.1294 |
3185 | HNRNPF | A001-C-108 | Human | Colorectum | FAP | 3.86e-02 | -1.28e-01 | -0.0272 |
3185 | HNRNPF | A002-C-205 | Human | Colorectum | FAP | 7.93e-05 | -2.41e-01 | -0.1236 |
3185 | HNRNPF | A015-C-006 | Human | Colorectum | FAP | 2.19e-02 | -2.03e-01 | -0.0994 |
3185 | HNRNPF | A015-C-106 | Human | Colorectum | FAP | 1.10e-02 | -1.09e-01 | -0.0511 |
3185 | HNRNPF | A002-C-114 | Human | Colorectum | FAP | 2.43e-03 | -1.97e-01 | -0.1561 |
3185 | HNRNPF | A015-C-104 | Human | Colorectum | FAP | 1.64e-06 | -1.75e-01 | -0.1899 |
3185 | HNRNPF | A001-C-014 | Human | Colorectum | FAP | 3.51e-02 | -1.30e-01 | 0.0135 |
3185 | HNRNPF | A002-C-016 | Human | Colorectum | FAP | 5.47e-05 | -9.81e-02 | 0.0521 |
3185 | HNRNPF | A002-C-116 | Human | Colorectum | FAP | 3.93e-09 | -1.57e-01 | -0.0452 |
3185 | HNRNPF | A014-C-008 | Human | Colorectum | FAP | 5.64e-03 | -2.76e-01 | -0.191 |
3185 | HNRNPF | A018-E-020 | Human | Colorectum | FAP | 1.16e-03 | -1.78e-01 | -0.2034 |
3185 | HNRNPF | F034 | Human | Colorectum | FAP | 1.44e-03 | -1.32e-01 | -0.0665 |
3185 | HNRNPF | AEH-subject1 | Human | Endometrium | AEH | 3.70e-02 | -1.54e-01 | -0.3059 |
3185 | HNRNPF | AEH-subject2 | Human | Endometrium | AEH | 3.79e-04 | -2.45e-01 | -0.2525 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00083809 | Breast | Precancer | RNA splicing | 65/1080 | 434/18723 | 1.27e-12 | 2.53e-10 | 65 |
GO:00434849 | Breast | Precancer | regulation of RNA splicing | 34/1080 | 148/18723 | 2.66e-12 | 4.75e-10 | 34 |
GO:00003759 | Breast | Precancer | RNA splicing, via transesterification reactions | 52/1080 | 324/18723 | 1.74e-11 | 2.22e-09 | 52 |
GO:00003779 | Breast | Precancer | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
GO:00003989 | Breast | Precancer | mRNA splicing, via spliceosome | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
GO:000838014 | Breast | IDC | RNA splicing | 73/1434 | 434/18723 | 1.27e-10 | 1.57e-08 | 73 |
GO:004348414 | Breast | IDC | regulation of RNA splicing | 36/1434 | 148/18723 | 3.32e-10 | 3.77e-08 | 36 |
GO:000037514 | Breast | IDC | RNA splicing, via transesterification reactions | 58/1434 | 324/18723 | 9.44e-10 | 9.58e-08 | 58 |
GO:000037714 | Breast | IDC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 57/1434 | 320/18723 | 1.60e-09 | 1.49e-07 | 57 |
GO:000039814 | Breast | IDC | mRNA splicing, via spliceosome | 57/1434 | 320/18723 | 1.60e-09 | 1.49e-07 | 57 |
GO:000838024 | Breast | DCIS | RNA splicing | 73/1390 | 434/18723 | 3.05e-11 | 5.08e-09 | 73 |
GO:004348424 | Breast | DCIS | regulation of RNA splicing | 36/1390 | 148/18723 | 1.40e-10 | 1.69e-08 | 36 |
GO:000037524 | Breast | DCIS | RNA splicing, via transesterification reactions | 58/1390 | 324/18723 | 2.89e-10 | 3.34e-08 | 58 |
GO:000037724 | Breast | DCIS | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 57/1390 | 320/18723 | 5.01e-10 | 5.35e-08 | 57 |
GO:000039824 | Breast | DCIS | mRNA splicing, via spliceosome | 57/1390 | 320/18723 | 5.01e-10 | 5.35e-08 | 57 |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0000377 | Colorectum | AD | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000398 | Colorectum | AD | mRNA splicing, via spliceosome | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000375 | Colorectum | AD | RNA splicing, via transesterification reactions | 131/3918 | 324/18723 | 7.11e-16 | 2.22e-13 | 131 |
GO:0043484 | Colorectum | AD | regulation of RNA splicing | 70/3918 | 148/18723 | 6.47e-13 | 1.16e-10 | 70 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HNRNPF | SNV | Missense_Mutation | novel | c.958G>C | p.Glu320Gln | p.E320Q | P52597 | protein_coding | tolerated(0.17) | benign(0.301) | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
HNRNPF | SNV | Missense_Mutation | rs780029236 | c.316N>A | p.Asp106Asn | p.D106N | P52597 | protein_coding | tolerated(0.11) | benign(0.037) | TCGA-E2-A14R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD |
HNRNPF | SNV | Missense_Mutation | novel | c.706N>C | p.Tyr236His | p.Y236H | P52597 | protein_coding | tolerated(0.15) | benign(0.104) | TCGA-E9-A54X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HNRNPF | SNV | Missense_Mutation | novel | c.162N>A | p.Ser54Arg | p.S54R | P52597 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
HNRNPF | SNV | Missense_Mutation | c.390N>A | p.Phe130Leu | p.F130L | P52597 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
HNRNPF | SNV | Missense_Mutation | c.528N>G | p.Ile176Met | p.I176M | P52597 | protein_coding | tolerated(0.08) | possibly_damaging(0.734) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HNRNPF | SNV | Missense_Mutation | c.337N>A | p.Val113Met | p.V113M | P52597 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AA-A02K-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | PD | |
HNRNPF | SNV | Missense_Mutation | c.295N>T | p.His99Tyr | p.H99Y | P52597 | protein_coding | deleterious(0.01) | possibly_damaging(0.465) | TCGA-F4-6461-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
HNRNPF | SNV | Missense_Mutation | c.1096G>T | p.Gly366Trp | p.G366W | P52597 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-G4-6299-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | SD | |
HNRNPF | SNV | Missense_Mutation | c.889C>T | p.Pro297Ser | p.P297S | P52597 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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