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Gene: HIVEP2 |
Gene summary for HIVEP2 |
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Gene information | Species | Human | Gene symbol | HIVEP2 | Gene ID | 3097 |
Gene name | HIVEP zinc finger 2 | |
Gene Alias | HIV-EP2 | |
Cytomap | 6q24.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P31629 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3097 | HIVEP2 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 1.69e-03 | 5.54e-01 | -0.0822 |
3097 | HIVEP2 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 5.18e-05 | 7.19e-01 | -0.0809 |
3097 | HIVEP2 | C04 | Human | Oral cavity | OSCC | 4.13e-02 | -2.70e-02 | 0.2633 |
3097 | HIVEP2 | C21 | Human | Oral cavity | OSCC | 2.83e-06 | -1.02e-01 | 0.2678 |
3097 | HIVEP2 | C30 | Human | Oral cavity | OSCC | 3.38e-06 | 6.03e-01 | 0.3055 |
3097 | HIVEP2 | C43 | Human | Oral cavity | OSCC | 3.73e-06 | -2.32e-01 | 0.1704 |
3097 | HIVEP2 | C46 | Human | Oral cavity | OSCC | 1.18e-06 | -2.97e-01 | 0.1673 |
3097 | HIVEP2 | C51 | Human | Oral cavity | OSCC | 3.27e-02 | -1.11e-01 | 0.2674 |
3097 | HIVEP2 | EOLP-1 | Human | Oral cavity | EOLP | 1.21e-14 | 3.95e-01 | -0.0202 |
3097 | HIVEP2 | NEOLP-1 | Human | Oral cavity | NEOLP | 6.92e-16 | 6.45e-01 | -0.0194 |
3097 | HIVEP2 | NEOLP-2 | Human | Oral cavity | NEOLP | 4.67e-09 | 3.92e-01 | -0.0196 |
3097 | HIVEP2 | NEOLP-3 | Human | Oral cavity | NEOLP | 2.22e-09 | 4.38e-01 | -0.0191 |
3097 | HIVEP2 | SYSMH1 | Human | Oral cavity | OSCC | 4.33e-06 | -1.47e-01 | 0.1127 |
3097 | HIVEP2 | SYSMH3 | Human | Oral cavity | OSCC | 5.61e-05 | -8.82e-02 | 0.2442 |
3097 | HIVEP2 | SYSMH4 | Human | Oral cavity | OSCC | 2.17e-07 | -3.23e-01 | 0.1226 |
3097 | HIVEP2 | SYSMH5 | Human | Oral cavity | OSCC | 7.12e-03 | -2.47e-01 | 0.0647 |
3097 | HIVEP2 | SYSMH6 | Human | Oral cavity | OSCC | 1.50e-05 | -2.26e-01 | 0.1275 |
3097 | HIVEP2 | HTA12-15-2 | Human | Pancreas | PDAC | 1.67e-09 | 7.66e-01 | 0.2315 |
3097 | HIVEP2 | HTA12-16-5 | Human | Pancreas | PDAC | 3.18e-06 | 7.16e-01 | 0.047 |
3097 | HIVEP2 | HTA12-18-3 | Human | Pancreas | PDAC | 1.00e-12 | 1.16e+00 | 0.0716 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIVEP2 | SNV | Missense_Mutation | novel | c.1516N>A | p.Gln506Lys | p.Q506K | P31629 | protein_coding | tolerated(0.11) | benign(0.024) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
HIVEP2 | SNV | Missense_Mutation | c.4517N>G | p.Asp1506Gly | p.D1506G | P31629 | protein_coding | tolerated(0.1) | possibly_damaging(0.707) | TCGA-A7-A26F-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | |
HIVEP2 | SNV | Missense_Mutation | c.6575N>A | p.Gly2192Asp | p.G2192D | P31629 | protein_coding | tolerated(0.37) | probably_damaging(0.928) | TCGA-A7-A3RF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | PD | |
HIVEP2 | SNV | Missense_Mutation | novel | c.838G>A | p.Asp280Asn | p.D280N | P31629 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HIVEP2 | SNV | Missense_Mutation | c.4601G>T | p.Arg1534Met | p.R1534M | P31629 | protein_coding | tolerated(0.18) | benign(0.174) | TCGA-AN-A0AT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HIVEP2 | SNV | Missense_Mutation | c.6290G>T | p.Arg2097Ile | p.R2097I | P31629 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-AO-A0JF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD | |
HIVEP2 | SNV | Missense_Mutation | novel | c.5661N>G | p.Ser1887Arg | p.S1887R | P31629 | protein_coding | tolerated(0.09) | probably_damaging(0.986) | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HIVEP2 | SNV | Missense_Mutation | c.4483N>A | p.Leu1495Met | p.L1495M | P31629 | protein_coding | deleterious(0.03) | possibly_damaging(0.809) | TCGA-AR-A1AO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
HIVEP2 | SNV | Missense_Mutation | c.1904N>T | p.Gly635Val | p.G635V | P31629 | protein_coding | tolerated(0.61) | benign(0) | TCGA-BH-A0H9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
HIVEP2 | SNV | Missense_Mutation | c.337A>G | p.Thr113Ala | p.T113A | P31629 | protein_coding | tolerated(1) | benign(0) | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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