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Gene: HIST1H3H |
Gene summary for HIST1H3H |
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Gene information | Species | Human | Gene symbol | HIST1H3H | Gene ID | 8357 |
Gene name | H3 clustered histone 10 | |
Gene Alias | H3/k | |
Cytomap | 6p22.1 | |
Gene Type | protein-coding | GO ID | GO:0006323 | UniProtAcc | P68431 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8357 | HIST1H3H | P47T-E | Human | Esophagus | ESCC | 4.30e-10 | 2.34e-01 | 0.1067 |
8357 | HIST1H3H | P48T-E | Human | Esophagus | ESCC | 6.56e-15 | 3.67e-01 | 0.0959 |
8357 | HIST1H3H | P49T-E | Human | Esophagus | ESCC | 5.23e-14 | 1.09e+00 | 0.1768 |
8357 | HIST1H3H | P52T-E | Human | Esophagus | ESCC | 9.78e-30 | 6.14e-01 | 0.1555 |
8357 | HIST1H3H | P54T-E | Human | Esophagus | ESCC | 5.63e-29 | 8.46e-01 | 0.0975 |
8357 | HIST1H3H | P56T-E | Human | Esophagus | ESCC | 1.75e-02 | 2.82e-01 | 0.1613 |
8357 | HIST1H3H | P57T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.53e-01 | 0.0926 |
8357 | HIST1H3H | P61T-E | Human | Esophagus | ESCC | 9.85e-28 | 6.60e-01 | 0.099 |
8357 | HIST1H3H | P62T-E | Human | Esophagus | ESCC | 4.14e-16 | 2.92e-01 | 0.1302 |
8357 | HIST1H3H | P65T-E | Human | Esophagus | ESCC | 6.26e-38 | 7.97e-01 | 0.0978 |
8357 | HIST1H3H | P74T-E | Human | Esophagus | ESCC | 2.89e-15 | 5.32e-01 | 0.1479 |
8357 | HIST1H3H | P75T-E | Human | Esophagus | ESCC | 3.87e-34 | 7.68e-01 | 0.1125 |
8357 | HIST1H3H | P76T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.56e-01 | 0.1207 |
8357 | HIST1H3H | P79T-E | Human | Esophagus | ESCC | 9.78e-30 | 6.33e-01 | 0.1154 |
8357 | HIST1H3H | P80T-E | Human | Esophagus | ESCC | 1.20e-05 | 1.68e-01 | 0.155 |
8357 | HIST1H3H | P82T-E | Human | Esophagus | ESCC | 6.28e-04 | 2.92e-01 | 0.1072 |
8357 | HIST1H3H | P83T-E | Human | Esophagus | ESCC | 2.82e-29 | 7.41e-01 | 0.1738 |
8357 | HIST1H3H | P84T-E | Human | Esophagus | ESCC | 8.33e-03 | 2.82e-01 | 0.0933 |
8357 | HIST1H3H | P89T-E | Human | Esophagus | ESCC | 5.43e-13 | 8.67e-01 | 0.1752 |
8357 | HIST1H3H | P91T-E | Human | Esophagus | ESCC | 3.13e-07 | 7.40e-01 | 0.1828 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIST1H3H | SNV | Missense_Mutation | novel | c.215T>G | p.Val72Gly | p.V72G | P68431 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.91) | TCGA-C8-A273-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
HIST1H3H | SNV | Missense_Mutation | c.292G>A | p.Glu98Lys | p.E98K | P68431 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.904) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
HIST1H3H | insertion | Frame_Shift_Ins | novel | c.54_55insA | p.Gln20AlafsTer55 | p.Q20Afs*55 | P68431 | protein_coding | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
HIST1H3H | SNV | Missense_Mutation | novel | c.268N>A | p.Val90Met | p.V90M | P68431 | protein_coding | tolerated_low_confidence(0.05) | benign(0.189) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
HIST1H3H | SNV | Missense_Mutation | novel | c.404N>T | p.Arg135Met | p.R135M | P68431 | protein_coding | deleterious_low_confidence(0) | benign(0.155) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
HIST1H3H | SNV | Missense_Mutation | novel | c.111G>T | p.Lys37Asn | p.K37N | P68431 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.876) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
HIST1H3H | SNV | Missense_Mutation | novel | c.40N>T | p.Gly14Cys | p.G14C | P68431 | protein_coding | deleterious_low_confidence(0) | benign(0.021) | TCGA-AX-A1C4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HIST1H3H | SNV | Missense_Mutation | novel | c.128G>A | p.Arg43Gln | p.R43Q | P68431 | protein_coding | deleterious_low_confidence(0) | benign(0.285) | TCGA-CC-A9FS-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
HIST1H3H | SNV | Missense_Mutation | c.406G>T | p.Ala136Ser | p.A136S | P68431 | protein_coding | tolerated_low_confidence(0.08) | benign(0.028) | TCGA-64-5778-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Targeted Molecular therapy | tarceva | PD | |
HIST1H3H | SNV | Missense_Mutation | c.382N>C | p.Ala128Pro | p.A128P | P68431 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.981) | TCGA-80-5611-01 | Lung | lung adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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