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Gene: HES2 |
Gene summary for HES2 |
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Gene information | Species | Human | Gene symbol | HES2 | Gene ID | 54626 |
Gene name | hes family bHLH transcription factor 2 | |
Gene Alias | bHLHb40 | |
Cytomap | 1p36.31 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9Y543 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54626 | HES2 | P126T-E | Human | Esophagus | ESCC | 1.42e-02 | 4.85e-01 | 0.1125 |
54626 | HES2 | P127T-E | Human | Esophagus | ESCC | 1.49e-12 | 2.83e-01 | 0.0826 |
54626 | HES2 | P130T-E | Human | Esophagus | ESCC | 6.58e-31 | 6.76e-01 | 0.1676 |
54626 | HES2 | HCC1 | Human | Liver | HCC | 1.78e-16 | 1.52e+00 | 0.5336 |
54626 | HES2 | HCC2 | Human | Liver | HCC | 2.73e-26 | 1.62e+00 | 0.5341 |
54626 | HES2 | HCC5 | Human | Liver | HCC | 2.84e-38 | 1.98e+00 | 0.4932 |
54626 | HES2 | C04 | Human | Oral cavity | OSCC | 5.08e-10 | 4.66e-01 | 0.2633 |
54626 | HES2 | C21 | Human | Oral cavity | OSCC | 1.09e-02 | 2.82e-01 | 0.2678 |
54626 | HES2 | C30 | Human | Oral cavity | OSCC | 2.69e-11 | 5.87e-01 | 0.3055 |
54626 | HES2 | C43 | Human | Oral cavity | OSCC | 4.53e-13 | 4.93e-01 | 0.1704 |
54626 | HES2 | C46 | Human | Oral cavity | OSCC | 7.75e-12 | 3.39e-01 | 0.1673 |
54626 | HES2 | C51 | Human | Oral cavity | OSCC | 8.72e-13 | 6.75e-01 | 0.2674 |
54626 | HES2 | C57 | Human | Oral cavity | OSCC | 7.68e-10 | 4.00e-01 | 0.1679 |
54626 | HES2 | C07 | Human | Oral cavity | OSCC | 2.71e-02 | 3.65e-01 | 0.2491 |
54626 | HES2 | C86 | Human | Oral cavity | OSCC | 3.83e-02 | 5.02e-01 | 0.161 |
54626 | HES2 | C09 | Human | Oral cavity | OSCC | 7.04e-07 | 2.57e-01 | 0.1431 |
54626 | HES2 | LN22 | Human | Oral cavity | OSCC | 2.24e-09 | 9.20e-01 | 0.1733 |
54626 | HES2 | LN46 | Human | Oral cavity | OSCC | 1.17e-03 | 3.31e-01 | 0.1666 |
54626 | HES2 | LP15 | Human | Oral cavity | LP | 8.87e-04 | 7.67e-01 | 0.2174 |
54626 | HES2 | SYSMH1 | Human | Oral cavity | OSCC | 7.94e-23 | 7.01e-01 | 0.1127 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005076710 | Esophagus | ESCC | regulation of neurogenesis | 203/8552 | 364/18723 | 6.10e-05 | 4.68e-04 | 203 |
GO:00519606 | Esophagus | ESCC | regulation of nervous system development | 237/8552 | 443/18723 | 5.02e-04 | 2.78e-03 | 237 |
GO:00507674 | Liver | HCC | regulation of neurogenesis | 181/7958 | 364/18723 | 3.00e-03 | 1.40e-02 | 181 |
GO:00507679 | Oral cavity | OSCC | regulation of neurogenesis | 179/7305 | 364/18723 | 4.49e-05 | 3.84e-04 | 179 |
GO:00519605 | Oral cavity | OSCC | regulation of nervous system development | 205/7305 | 443/18723 | 9.80e-04 | 5.11e-03 | 205 |
GO:005076722 | Skin | cSCC | regulation of neurogenesis | 118/4864 | 364/18723 | 3.32e-03 | 1.81e-02 | 118 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0516510 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa0516515 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa051652 | Liver | HCC | Human papillomavirus infection | 188/4020 | 331/8465 | 3.34e-04 | 1.49e-03 | 8.29e-04 | 188 |
hsa051653 | Liver | HCC | Human papillomavirus infection | 188/4020 | 331/8465 | 3.34e-04 | 1.49e-03 | 8.29e-04 | 188 |
hsa051659 | Oral cavity | OSCC | Human papillomavirus infection | 200/3704 | 331/8465 | 3.83e-10 | 4.93e-09 | 2.51e-09 | 200 |
hsa0516514 | Oral cavity | OSCC | Human papillomavirus infection | 200/3704 | 331/8465 | 3.83e-10 | 4.93e-09 | 2.51e-09 | 200 |
hsa0516523 | Oral cavity | LP | Human papillomavirus infection | 121/2418 | 331/8465 | 8.00e-04 | 3.86e-03 | 2.49e-03 | 121 |
hsa0516533 | Oral cavity | LP | Human papillomavirus infection | 121/2418 | 331/8465 | 8.00e-04 | 3.86e-03 | 2.49e-03 | 121 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HES2 | SNV | Missense_Mutation | novel | c.194N>A | p.Arg65His | p.R65H | Q9Y543 | protein_coding | tolerated(0.08) | benign(0.111) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HES2 | SNV | Missense_Mutation | c.163N>A | p.Glu55Lys | p.E55K | Q9Y543 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-55-A48Y-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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