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Gene: HACD3 |
Gene summary for HACD3 |
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Gene information | Species | Human | Gene symbol | HACD3 | Gene ID | 51495 |
Gene name | 3-hydroxyacyl-CoA dehydratase 3 | |
Gene Alias | B-IND1 | |
Cytomap | 15q22.31 | |
Gene Type | protein-coding | GO ID | GO:0000038 | UniProtAcc | Q9P035 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51495 | HACD3 | P17T-E | Human | Esophagus | ESCC | 1.71e-06 | 5.31e-01 | 0.1278 |
51495 | HACD3 | P19T-E | Human | Esophagus | ESCC | 1.40e-05 | 7.48e-01 | 0.1662 |
51495 | HACD3 | P20T-E | Human | Esophagus | ESCC | 1.43e-44 | 1.09e+00 | 0.1124 |
51495 | HACD3 | P21T-E | Human | Esophagus | ESCC | 1.86e-41 | 1.02e+00 | 0.1617 |
51495 | HACD3 | P22T-E | Human | Esophagus | ESCC | 4.00e-95 | 1.57e+00 | 0.1236 |
51495 | HACD3 | P23T-E | Human | Esophagus | ESCC | 1.09e-45 | 1.27e+00 | 0.108 |
51495 | HACD3 | P24T-E | Human | Esophagus | ESCC | 5.02e-24 | 6.57e-01 | 0.1287 |
51495 | HACD3 | P26T-E | Human | Esophagus | ESCC | 4.90e-67 | 1.34e+00 | 0.1276 |
51495 | HACD3 | P27T-E | Human | Esophagus | ESCC | 6.96e-52 | 1.00e+00 | 0.1055 |
51495 | HACD3 | P28T-E | Human | Esophagus | ESCC | 7.41e-44 | 1.06e+00 | 0.1149 |
51495 | HACD3 | P30T-E | Human | Esophagus | ESCC | 3.08e-44 | 1.67e+00 | 0.137 |
51495 | HACD3 | P31T-E | Human | Esophagus | ESCC | 1.02e-45 | 9.24e-01 | 0.1251 |
51495 | HACD3 | P32T-E | Human | Esophagus | ESCC | 3.26e-52 | 1.01e+00 | 0.1666 |
51495 | HACD3 | P36T-E | Human | Esophagus | ESCC | 2.21e-30 | 1.14e+00 | 0.1187 |
51495 | HACD3 | P37T-E | Human | Esophagus | ESCC | 1.13e-39 | 1.04e+00 | 0.1371 |
51495 | HACD3 | P38T-E | Human | Esophagus | ESCC | 8.72e-04 | 1.74e-01 | 0.127 |
51495 | HACD3 | P39T-E | Human | Esophagus | ESCC | 1.61e-25 | 7.12e-01 | 0.0894 |
51495 | HACD3 | P40T-E | Human | Esophagus | ESCC | 1.29e-07 | 3.19e-01 | 0.109 |
51495 | HACD3 | P42T-E | Human | Esophagus | ESCC | 3.87e-39 | 1.11e+00 | 0.1175 |
51495 | HACD3 | P44T-E | Human | Esophagus | ESCC | 8.95e-17 | 6.59e-01 | 0.1096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160329 | Breast | Precancer | viral process | 58/1080 | 415/18723 | 3.42e-10 | 3.16e-08 | 58 |
GO:00190589 | Breast | Precancer | viral life cycle | 47/1080 | 317/18723 | 2.42e-09 | 1.99e-07 | 47 |
GO:00507929 | Breast | Precancer | regulation of viral process | 27/1080 | 164/18723 | 7.59e-07 | 3.05e-05 | 27 |
GO:00190799 | Breast | Precancer | viral genome replication | 22/1080 | 131/18723 | 5.63e-06 | 1.66e-04 | 22 |
GO:19039009 | Breast | Precancer | regulation of viral life cycle | 23/1080 | 148/18723 | 1.31e-05 | 3.30e-04 | 23 |
GO:00485249 | Breast | Precancer | positive regulation of viral process | 12/1080 | 65/18723 | 3.00e-04 | 4.34e-03 | 12 |
GO:00450697 | Breast | Precancer | regulation of viral genome replication | 13/1080 | 85/18723 | 1.12e-03 | 1.23e-02 | 13 |
GO:00463946 | Breast | Precancer | carboxylic acid biosynthetic process | 32/1080 | 314/18723 | 1.30e-03 | 1.38e-02 | 32 |
GO:00723304 | Breast | Precancer | monocarboxylic acid biosynthetic process | 24/1080 | 214/18723 | 1.41e-03 | 1.48e-02 | 24 |
GO:00160536 | Breast | Precancer | organic acid biosynthetic process | 32/1080 | 316/18723 | 1.44e-03 | 1.50e-02 | 32 |
GO:00066335 | Breast | Precancer | fatty acid biosynthetic process | 19/1080 | 163/18723 | 2.74e-03 | 2.42e-02 | 19 |
GO:00072496 | Breast | Precancer | I-kappaB kinase/NF-kappaB signaling | 27/1080 | 281/18723 | 6.58e-03 | 4.53e-02 | 27 |
GO:001603214 | Breast | IDC | viral process | 75/1434 | 415/18723 | 1.98e-12 | 4.02e-10 | 75 |
GO:001905814 | Breast | IDC | viral life cycle | 61/1434 | 317/18723 | 1.61e-11 | 2.77e-09 | 61 |
GO:001907914 | Breast | IDC | viral genome replication | 32/1434 | 131/18723 | 2.82e-09 | 2.46e-07 | 32 |
GO:005079214 | Breast | IDC | regulation of viral process | 36/1434 | 164/18723 | 6.55e-09 | 5.03e-07 | 36 |
GO:190390014 | Breast | IDC | regulation of viral life cycle | 30/1434 | 148/18723 | 7.25e-07 | 3.35e-05 | 30 |
GO:004506913 | Breast | IDC | regulation of viral genome replication | 20/1434 | 85/18723 | 4.77e-06 | 1.63e-04 | 20 |
GO:004852413 | Breast | IDC | positive regulation of viral process | 17/1434 | 65/18723 | 5.31e-06 | 1.75e-04 | 17 |
GO:00450706 | Breast | IDC | positive regulation of viral genome replication | 9/1434 | 30/18723 | 2.89e-04 | 4.39e-03 | 9 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012129 | Esophagus | ESCC | Fatty acid metabolism | 41/4205 | 57/8465 | 5.13e-04 | 1.75e-03 | 8.98e-04 | 41 |
hsa0121214 | Esophagus | ESCC | Fatty acid metabolism | 41/4205 | 57/8465 | 5.13e-04 | 1.75e-03 | 8.98e-04 | 41 |
hsa012126 | Liver | NAFLD | Fatty acid metabolism | 17/1043 | 57/8465 | 3.43e-04 | 5.93e-03 | 4.78e-03 | 17 |
hsa0121211 | Liver | NAFLD | Fatty acid metabolism | 17/1043 | 57/8465 | 3.43e-04 | 5.93e-03 | 4.78e-03 | 17 |
hsa012122 | Liver | Cirrhotic | Fatty acid metabolism | 32/2530 | 57/8465 | 3.12e-05 | 2.47e-04 | 1.52e-04 | 32 |
hsa01040 | Liver | Cirrhotic | Biosynthesis of unsaturated fatty acids | 14/2530 | 27/8465 | 1.36e-02 | 4.25e-02 | 2.62e-02 | 14 |
hsa012123 | Liver | Cirrhotic | Fatty acid metabolism | 32/2530 | 57/8465 | 3.12e-05 | 2.47e-04 | 1.52e-04 | 32 |
hsa010401 | Liver | Cirrhotic | Biosynthesis of unsaturated fatty acids | 14/2530 | 27/8465 | 1.36e-02 | 4.25e-02 | 2.62e-02 | 14 |
hsa012124 | Liver | HCC | Fatty acid metabolism | 45/4020 | 57/8465 | 1.05e-06 | 1.10e-05 | 6.09e-06 | 45 |
hsa000622 | Liver | HCC | Fatty acid elongation | 20/4020 | 27/8465 | 4.58e-03 | 1.36e-02 | 7.55e-03 | 20 |
hsa010402 | Liver | HCC | Biosynthesis of unsaturated fatty acids | 19/4020 | 27/8465 | 1.37e-02 | 3.33e-02 | 1.85e-02 | 19 |
hsa012125 | Liver | HCC | Fatty acid metabolism | 45/4020 | 57/8465 | 1.05e-06 | 1.10e-05 | 6.09e-06 | 45 |
hsa0006211 | Liver | HCC | Fatty acid elongation | 20/4020 | 27/8465 | 4.58e-03 | 1.36e-02 | 7.55e-03 | 20 |
hsa010403 | Liver | HCC | Biosynthesis of unsaturated fatty acids | 19/4020 | 27/8465 | 1.37e-02 | 3.33e-02 | 1.85e-02 | 19 |
hsa012128 | Oral cavity | OSCC | Fatty acid metabolism | 35/3704 | 57/8465 | 5.37e-03 | 1.29e-02 | 6.55e-03 | 35 |
hsa0121213 | Oral cavity | OSCC | Fatty acid metabolism | 35/3704 | 57/8465 | 5.37e-03 | 1.29e-02 | 6.55e-03 | 35 |
hsa012127 | Prostate | BPH | Fatty acid metabolism | 19/1718 | 57/8465 | 1.44e-02 | 4.17e-02 | 2.58e-02 | 19 |
hsa0121212 | Prostate | BPH | Fatty acid metabolism | 19/1718 | 57/8465 | 1.44e-02 | 4.17e-02 | 2.58e-02 | 19 |
hsa0121221 | Prostate | Tumor | Fatty acid metabolism | 23/1791 | 57/8465 | 7.60e-04 | 3.59e-03 | 2.23e-03 | 23 |
hsa010404 | Prostate | Tumor | Biosynthesis of unsaturated fatty acids | 12/1791 | 27/8465 | 5.53e-03 | 1.93e-02 | 1.19e-02 | 12 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HACD3 | SNV | Missense_Mutation | rs775563054 | c.233N>G | p.Val78Gly | p.V78G | Q9P035 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-A2-A1G4-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | adriamycin | SD |
HACD3 | SNV | Missense_Mutation | rs775563054 | c.233T>G | p.Val78Gly | p.V78G | Q9P035 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-BH-A1EX-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HACD3 | SNV | Missense_Mutation | rs775563054 | c.233N>G | p.Val78Gly | p.V78G | Q9P035 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-C8-A12X-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HACD3 | SNV | Missense_Mutation | rs775563054 | c.233N>G | p.Val78Gly | p.V78G | Q9P035 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-D8-A1Y3-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicine+cyclophosphamide | SD |
HACD3 | SNV | Missense_Mutation | rs775563054 | c.233N>G | p.Val78Gly | p.V78G | Q9P035 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-EW-A1IW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | aromasin | SD |
HACD3 | SNV | Missense_Mutation | novel | c.231N>T | p.Gln77His | p.Q77H | Q9P035 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-JL-A3YW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HACD3 | deletion | Frame_Shift_Del | novel | c.736delN | p.Phe246LeufsTer19 | p.F246Lfs*19 | Q9P035 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
HACD3 | deletion | Frame_Shift_Del | novel | c.767delN | p.Phe257SerfsTer8 | p.F257Sfs*8 | Q9P035 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
HACD3 | SNV | Missense_Mutation | c.1074G>T | p.Lys358Asn | p.K358N | Q9P035 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-VS-A9V3-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
HACD3 | deletion | Frame_Shift_Del | novel | c.1073delA | p.Lys358ArgfsTer17 | p.K358Rfs*17 | Q9P035 | protein_coding | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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