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Gene: H2AFZ |
Gene summary for H2AFZ |
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Gene information | Species | Human | Gene symbol | H2AFZ | Gene ID | 3015 |
Gene name | H2A.Z variant histone 1 | |
Gene Alias | H2A.Z-1 | |
Cytomap | 4q23 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P0C0S5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3015 | H2AFZ | L1 | Human | Cervix | CC | 1.92e-34 | 1.04e+00 | 0.0802 |
3015 | H2AFZ | T1 | Human | Cervix | CC | 1.10e-71 | 1.21e+00 | 0.0918 |
3015 | H2AFZ | T2 | Human | Cervix | CC | 1.43e-37 | 1.03e+00 | 0.0709 |
3015 | H2AFZ | T3 | Human | Cervix | CC | 3.33e-111 | 1.30e+00 | 0.1389 |
3015 | H2AFZ | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.98e-30 | 8.99e-01 | 0.294 |
3015 | H2AFZ | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 4.30e-06 | 1.23e+00 | 0.3487 |
3015 | H2AFZ | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.18e-24 | 7.61e-01 | 0.3859 |
3015 | H2AFZ | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.09e-04 | 4.86e-01 | 0.2585 |
3015 | H2AFZ | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.50e-08 | 2.99e-01 | 0.3005 |
3015 | H2AFZ | AEH-subject1 | Human | Endometrium | AEH | 3.88e-05 | -2.61e-01 | -0.3059 |
3015 | H2AFZ | AEH-subject2 | Human | Endometrium | AEH | 4.02e-09 | -2.70e-01 | -0.2525 |
3015 | H2AFZ | AEH-subject3 | Human | Endometrium | AEH | 2.98e-10 | -2.65e-01 | -0.2576 |
3015 | H2AFZ | AEH-subject4 | Human | Endometrium | AEH | 5.08e-04 | -1.86e-01 | -0.2657 |
3015 | H2AFZ | AEH-subject5 | Human | Endometrium | AEH | 2.26e-10 | -2.33e-01 | -0.2953 |
3015 | H2AFZ | EEC-subject1 | Human | Endometrium | EEC | 3.82e-11 | -2.53e-01 | -0.2682 |
3015 | H2AFZ | EEC-subject2 | Human | Endometrium | EEC | 5.64e-18 | -4.88e-01 | -0.2607 |
3015 | H2AFZ | EEC-subject3 | Human | Endometrium | EEC | 2.21e-43 | -3.99e-01 | -0.2525 |
3015 | H2AFZ | EEC-subject4 | Human | Endometrium | EEC | 5.90e-04 | -2.20e-01 | -0.2571 |
3015 | H2AFZ | EEC-subject5 | Human | Endometrium | EEC | 2.18e-02 | -3.25e-02 | -0.249 |
3015 | H2AFZ | GSM5276934 | Human | Endometrium | EEC | 3.71e-02 | -2.40e-01 | -0.0913 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05322 | Cervix | HSIL_HPV | Systemic lupus erythematosus | 19/459 | 137/8465 | 1.40e-04 | 1.74e-03 | 1.40e-03 | 19 |
hsa053221 | Cervix | HSIL_HPV | Systemic lupus erythematosus | 19/459 | 137/8465 | 1.40e-04 | 1.74e-03 | 1.40e-03 | 19 |
hsa04217 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
hsa042171 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
H2AFZ | SNV | Missense_Mutation | c.241N>T | p.Arg81Cys | p.R81C | P0C0S5 | protein_coding | deleterious(0.03) | benign(0.025) | TCGA-A1-A0SF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | tc | SD | |
H2AFZ | SNV | Missense_Mutation | c.241C>T | p.Arg81Cys | p.R81C | P0C0S5 | protein_coding | deleterious(0.03) | benign(0.025) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
H2AFZ | SNV | Missense_Mutation | c.24N>C | p.Lys8Asn | p.K8N | P0C0S5 | protein_coding | deleterious(0.03) | possibly_damaging(0.771) | TCGA-B6-A0IB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
H2AFZ | SNV | Missense_Mutation | c.116N>A | p.Ser39Tyr | p.S39Y | P0C0S5 | protein_coding | deleterious(0) | benign(0.275) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
H2AFZ | SNV | Missense_Mutation | c.127N>T | p.Ser43Cys | p.S43C | P0C0S5 | protein_coding | deleterious(0.03) | probably_damaging(0.962) | TCGA-DY-A1DF-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
H2AFZ | SNV | Missense_Mutation | novel | c.296N>A | p.Ser99Tyr | p.S99Y | P0C0S5 | protein_coding | deleterious(0) | possibly_damaging(0.675) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
H2AFZ | SNV | Missense_Mutation | novel | c.128N>T | p.Ser43Ile | p.S43I | P0C0S5 | protein_coding | deleterious(0.01) | probably_damaging(0.97) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
H2AFZ | SNV | Missense_Mutation | c.217G>A | p.Ala73Thr | p.A73T | P0C0S5 | protein_coding | deleterious(0.02) | possibly_damaging(0.577) | TCGA-BS-A0TE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
H2AFZ | SNV | Missense_Mutation | c.314N>G | p.Ile105Ser | p.I105S | P0C0S5 | protein_coding | deleterious(0) | benign(0.315) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
H2AFZ | SNV | Missense_Mutation | c.325N>T | p.Gly109Cys | p.G109C | P0C0S5 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-D1-A17B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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