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Gene: GTPBP2 |
Gene summary for GTPBP2 |
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Gene information | Species | Human | Gene symbol | GTPBP2 | Gene ID | 54676 |
Gene name | GTP binding protein 2 | |
Gene Alias | JABELS | |
Cytomap | 6p21.1 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | A8K2K2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54676 | GTPBP2 | HCC2_Meng | Human | Liver | HCC | 1.71e-07 | 8.28e-02 | 0.0107 |
54676 | GTPBP2 | HCC2 | Human | Liver | HCC | 1.50e-06 | 1.84e+00 | 0.5341 |
54676 | GTPBP2 | Pt13.b | Human | Liver | HCC | 2.00e-03 | 1.04e-01 | 0.0251 |
54676 | GTPBP2 | S014 | Human | Liver | HCC | 1.18e-03 | 2.55e-01 | 0.2254 |
54676 | GTPBP2 | S015 | Human | Liver | HCC | 9.57e-05 | 2.69e-01 | 0.2375 |
54676 | GTPBP2 | S027 | Human | Liver | HCC | 2.97e-07 | 5.56e-01 | 0.2446 |
54676 | GTPBP2 | S028 | Human | Liver | HCC | 3.60e-12 | 5.07e-01 | 0.2503 |
54676 | GTPBP2 | S029 | Human | Liver | HCC | 4.13e-11 | 5.45e-01 | 0.2581 |
54676 | GTPBP2 | C04 | Human | Oral cavity | OSCC | 1.74e-03 | 2.22e-01 | 0.2633 |
54676 | GTPBP2 | C30 | Human | Oral cavity | OSCC | 2.40e-13 | 5.69e-01 | 0.3055 |
54676 | GTPBP2 | C51 | Human | Oral cavity | OSCC | 6.32e-05 | 3.71e-01 | 0.2674 |
54676 | GTPBP2 | C57 | Human | Oral cavity | OSCC | 3.47e-16 | 6.35e-01 | 0.1679 |
54676 | GTPBP2 | C08 | Human | Oral cavity | OSCC | 1.27e-03 | 1.19e-01 | 0.1919 |
54676 | GTPBP2 | SYSMH2 | Human | Oral cavity | OSCC | 4.95e-04 | 1.64e-01 | 0.2326 |
54676 | GTPBP2 | SYSMH3 | Human | Oral cavity | OSCC | 3.59e-02 | 1.53e-01 | 0.2442 |
54676 | GTPBP2 | SYSMH6 | Human | Oral cavity | OSCC | 7.62e-03 | 1.38e-01 | 0.1275 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000641419 | Esophagus | ESCC | translational elongation | 41/8552 | 55/18723 | 1.26e-05 | 1.16e-04 | 41 |
GO:000641412 | Liver | HCC | translational elongation | 36/7958 | 55/18723 | 4.94e-04 | 3.23e-03 | 36 |
GO:000641416 | Oral cavity | OSCC | translational elongation | 37/7305 | 55/18723 | 2.03e-05 | 1.94e-04 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GTPBP2 | SNV | Missense_Mutation | c.555N>C | p.Lys185Asn | p.K185N | Q9BX10 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B6-A0WV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GTPBP2 | SNV | Missense_Mutation | novel | c.401N>G | p.Val134Gly | p.V134G | Q9BX10 | protein_coding | deleterious(0) | possibly_damaging(0.497) | TCGA-D8-A1XT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD |
GTPBP2 | insertion | Frame_Shift_Ins | novel | c.1478_1479insAAAAGCAGAAAATATTTTTGAAGAAAAAAATTTCCTG | p.Met493IlefsTer27 | p.M493Ifs*27 | Q9BX10 | protein_coding | TCGA-A2-A0ER-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
GTPBP2 | insertion | Frame_Shift_Ins | novel | c.1413_1414insTTCTGGAGAGGTGCCAAACTTGGTGTGGCCAGGAAAGG | p.Gly472PhefsTer34 | p.G472Ffs*34 | Q9BX10 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |||
GTPBP2 | SNV | Missense_Mutation | rs770981387 | c.301G>A | p.Val101Ile | p.V101I | Q9BX10 | protein_coding | tolerated(1) | benign(0.003) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GTPBP2 | SNV | Missense_Mutation | c.1292C>G | p.Ser431Cys | p.S431C | Q9BX10 | protein_coding | tolerated(0.14) | benign(0.338) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
GTPBP2 | SNV | Missense_Mutation | rs769723702 | c.1382G>A | p.Arg461His | p.R461H | Q9BX10 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
GTPBP2 | SNV | Missense_Mutation | rs754859335 | c.1243G>A | p.Glu415Lys | p.E415K | Q9BX10 | protein_coding | deleterious(0.02) | probably_damaging(0.978) | TCGA-AA-3851-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GTPBP2 | SNV | Missense_Mutation | novel | c.807N>G | p.His269Gln | p.H269Q | Q9BX10 | protein_coding | deleterious(0) | benign(0) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GTPBP2 | SNV | Missense_Mutation | rs779230466 | c.1585N>A | p.Val529Met | p.V529M | Q9BX10 | protein_coding | deleterious(0.01) | possibly_damaging(0.824) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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