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Gene: GPR160 |
Gene summary for GPR160 |
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Gene information | Species | Human | Gene symbol | GPR160 | Gene ID | 26996 |
Gene name | G protein-coupled receptor 160 | |
Gene Alias | GPCR1 | |
Cytomap | 3q26.2 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q9UJ42 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26996 | GPR160 | A001-C-007 | Human | Colorectum | CRC | 9.24e-06 | -5.81e-01 | 0.1899 |
26996 | GPR160 | A001-C-203 | Human | Colorectum | FAP | 4.42e-08 | -1.72e-01 | -0.0481 |
26996 | GPR160 | A002-C-116 | Human | Colorectum | FAP | 1.16e-28 | -1.73e-01 | -0.0452 |
26996 | GPR160 | A014-C-008 | Human | Colorectum | FAP | 5.62e-10 | -1.46e-01 | -0.191 |
26996 | GPR160 | A018-E-020 | Human | Colorectum | FAP | 1.27e-19 | -3.44e-01 | -0.2034 |
26996 | GPR160 | F034 | Human | Colorectum | FAP | 1.74e-15 | -2.42e-01 | -0.0665 |
26996 | GPR160 | F072B | Human | Colorectum | FAP | 3.57e-05 | -1.80e-01 | 0.257 |
26996 | GPR160 | CRC-1-8810 | Human | Colorectum | CRC | 6.94e-17 | -5.26e-01 | 0.6257 |
26996 | GPR160 | CRC-3-11773 | Human | Colorectum | CRC | 2.79e-05 | -1.03e-01 | 0.2564 |
26996 | GPR160 | LZE24T | Human | Esophagus | ESCC | 5.43e-09 | 4.37e-01 | 0.0596 |
26996 | GPR160 | P4T-E | Human | Esophagus | ESCC | 2.46e-03 | 1.19e-01 | 0.1323 |
26996 | GPR160 | P5T-E | Human | Esophagus | ESCC | 2.23e-07 | 8.31e-02 | 0.1327 |
26996 | GPR160 | P8T-E | Human | Esophagus | ESCC | 4.76e-11 | 2.85e-01 | 0.0889 |
26996 | GPR160 | P23T-E | Human | Esophagus | ESCC | 4.04e-05 | 1.98e-01 | 0.108 |
26996 | GPR160 | P26T-E | Human | Esophagus | ESCC | 5.90e-03 | 6.78e-02 | 0.1276 |
26996 | GPR160 | P27T-E | Human | Esophagus | ESCC | 1.36e-05 | 7.42e-02 | 0.1055 |
26996 | GPR160 | P28T-E | Human | Esophagus | ESCC | 3.53e-33 | 6.25e-01 | 0.1149 |
26996 | GPR160 | P39T-E | Human | Esophagus | ESCC | 5.01e-21 | 7.76e-01 | 0.0894 |
26996 | GPR160 | P54T-E | Human | Esophagus | ESCC | 7.04e-03 | 1.67e-01 | 0.0975 |
26996 | GPR160 | P57T-E | Human | Esophagus | ESCC | 7.06e-06 | 1.63e-01 | 0.0926 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPR160 | SNV | Missense_Mutation | c.395N>A | p.Phe132Tyr | p.F132Y | Q9UJ42 | protein_coding | tolerated(1) | benign(0.116) | TCGA-A2-A0YF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unspecific | Arimidex | SD | |
GPR160 | SNV | Missense_Mutation | novel | c.374N>T | p.Ser125Phe | p.S125F | Q9UJ42 | protein_coding | tolerated(0.08) | benign(0.026) | TCGA-A8-A09I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
GPR160 | SNV | Missense_Mutation | novel | c.295N>G | p.Gln99Glu | p.Q99E | Q9UJ42 | protein_coding | deleterious(0.02) | benign(0.017) | TCGA-ZJ-AAXU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
GPR160 | SNV | Missense_Mutation | novel | c.501N>T | p.Gln167His | p.Q167H | Q9UJ42 | protein_coding | tolerated(0.16) | benign(0.006) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
GPR160 | SNV | Missense_Mutation | rs372339784 | c.515G>A | p.Arg172His | p.R172H | Q9UJ42 | protein_coding | tolerated(0.51) | benign(0) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GPR160 | SNV | Missense_Mutation | c.745N>A | p.Leu249Ile | p.L249I | Q9UJ42 | protein_coding | deleterious(0.01) | probably_damaging(0.959) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GPR160 | deletion | Frame_Shift_Del | c.715delA | p.Ile239TyrfsTer22 | p.I239Yfs*22 | Q9UJ42 | protein_coding | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |||
GPR160 | deletion | Frame_Shift_Del | c.715delA | p.Ile239TyrfsTer22 | p.I239Yfs*22 | Q9UJ42 | protein_coding | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |||
GPR160 | deletion | Frame_Shift_Del | c.715delA | p.Ile239TyrfsTer22 | p.I239Yfs*22 | Q9UJ42 | protein_coding | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
GPR160 | insertion | In_Frame_Ins | novel | c.921_922insGAAGTAGTACAAATGGTAACCAGGTAC | p.Pro307_Leu308insGluValValGlnMetValThrArgTyr | p.P307_L308insEVVQMVTRY | Q9UJ42 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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