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Gene: GGCX |
Gene summary for GGCX |
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Gene information | Species | Human | Gene symbol | GGCX | Gene ID | 2677 |
Gene name | gamma-glutamyl carboxylase | |
Gene Alias | VKCFD1 | |
Cytomap | 2p11.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | P38435 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2677 | GGCX | P52T-E | Human | Esophagus | ESCC | 2.14e-16 | 2.92e-01 | 0.1555 |
2677 | GGCX | P54T-E | Human | Esophagus | ESCC | 1.55e-19 | 4.57e-01 | 0.0975 |
2677 | GGCX | P56T-E | Human | Esophagus | ESCC | 1.73e-04 | 7.54e-01 | 0.1613 |
2677 | GGCX | P57T-E | Human | Esophagus | ESCC | 4.18e-10 | 2.97e-01 | 0.0926 |
2677 | GGCX | P61T-E | Human | Esophagus | ESCC | 4.09e-09 | 2.80e-01 | 0.099 |
2677 | GGCX | P62T-E | Human | Esophagus | ESCC | 4.14e-20 | 3.25e-01 | 0.1302 |
2677 | GGCX | P65T-E | Human | Esophagus | ESCC | 2.48e-18 | 2.51e-01 | 0.0978 |
2677 | GGCX | P74T-E | Human | Esophagus | ESCC | 1.88e-33 | 8.59e-01 | 0.1479 |
2677 | GGCX | P75T-E | Human | Esophagus | ESCC | 2.88e-47 | 8.54e-01 | 0.1125 |
2677 | GGCX | P76T-E | Human | Esophagus | ESCC | 1.22e-17 | 3.43e-01 | 0.1207 |
2677 | GGCX | P79T-E | Human | Esophagus | ESCC | 6.72e-30 | 4.88e-01 | 0.1154 |
2677 | GGCX | P80T-E | Human | Esophagus | ESCC | 1.10e-13 | 5.84e-01 | 0.155 |
2677 | GGCX | P82T-E | Human | Esophagus | ESCC | 6.51e-14 | 6.75e-01 | 0.1072 |
2677 | GGCX | P83T-E | Human | Esophagus | ESCC | 1.69e-29 | 8.97e-01 | 0.1738 |
2677 | GGCX | P84T-E | Human | Esophagus | ESCC | 1.48e-07 | 2.80e-01 | 0.0933 |
2677 | GGCX | P89T-E | Human | Esophagus | ESCC | 8.36e-07 | 6.72e-01 | 0.1752 |
2677 | GGCX | P91T-E | Human | Esophagus | ESCC | 2.89e-07 | 9.40e-01 | 0.1828 |
2677 | GGCX | P107T-E | Human | Esophagus | ESCC | 4.65e-30 | 7.89e-01 | 0.171 |
2677 | GGCX | P126T-E | Human | Esophagus | ESCC | 6.79e-04 | 3.98e-01 | 0.1125 |
2677 | GGCX | P127T-E | Human | Esophagus | ESCC | 2.75e-17 | 7.19e-02 | 0.0826 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004206027 | Esophagus | ESCC | wound healing | 243/8552 | 422/18723 | 4.62e-07 | 6.25e-06 | 243 |
GO:004206012 | Liver | Cirrhotic | wound healing | 155/4634 | 422/18723 | 2.12e-08 | 7.56e-07 | 155 |
GO:000759611 | Liver | Cirrhotic | blood coagulation | 79/4634 | 217/18723 | 8.06e-05 | 8.81e-04 | 79 |
GO:000759911 | Liver | Cirrhotic | hemostasis | 80/4634 | 222/18723 | 1.08e-04 | 1.10e-03 | 80 |
GO:005081711 | Liver | Cirrhotic | coagulation | 79/4634 | 222/18723 | 1.90e-04 | 1.76e-03 | 79 |
GO:005087812 | Liver | Cirrhotic | regulation of body fluid levels | 118/4634 | 379/18723 | 2.65e-03 | 1.55e-02 | 118 |
GO:004206022 | Liver | HCC | wound healing | 219/7958 | 422/18723 | 5.34e-05 | 5.04e-04 | 219 |
GO:00075962 | Liver | HCC | blood coagulation | 118/7958 | 217/18723 | 2.63e-04 | 1.94e-03 | 118 |
GO:00075992 | Liver | HCC | hemostasis | 119/7958 | 222/18723 | 5.25e-04 | 3.41e-03 | 119 |
GO:00508172 | Liver | HCC | coagulation | 118/7958 | 222/18723 | 8.41e-04 | 5.03e-03 | 118 |
GO:005087822 | Liver | HCC | regulation of body fluid levels | 191/7958 | 379/18723 | 1.06e-03 | 6.11e-03 | 191 |
GO:004206020 | Oral cavity | OSCC | wound healing | 237/7305 | 422/18723 | 4.51e-13 | 2.18e-11 | 237 |
GO:005087819 | Oral cavity | OSCC | regulation of body fluid levels | 179/7305 | 379/18723 | 6.19e-04 | 3.50e-03 | 179 |
GO:00075969 | Oral cavity | OSCC | blood coagulation | 102/7305 | 217/18723 | 9.69e-03 | 3.43e-02 | 102 |
GO:00075999 | Oral cavity | OSCC | hemostasis | 103/7305 | 222/18723 | 1.45e-02 | 4.73e-02 | 103 |
GO:00508179 | Oral cavity | OSCC | coagulation | 103/7305 | 222/18723 | 1.45e-02 | 4.73e-02 | 103 |
GO:0042060110 | Oral cavity | LP | wound healing | 139/4623 | 422/18723 | 7.10e-05 | 9.48e-04 | 139 |
GO:0042060112 | Thyroid | PTC | wound healing | 190/5968 | 422/18723 | 7.72e-09 | 1.92e-07 | 190 |
GO:004206034 | Thyroid | ATC | wound healing | 210/6293 | 422/18723 | 3.33e-12 | 1.37e-10 | 210 |
GO:000759618 | Thyroid | ATC | blood coagulation | 93/6293 | 217/18723 | 2.69e-03 | 1.23e-02 | 93 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa01240 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa012401 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa012402 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa012403 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa012404 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa00130 | Oral cavity | OSCC | Ubiquinone and other terpenoid-quinone biosynthesis | 9/3704 | 11/8465 | 1.19e-02 | 2.62e-02 | 1.33e-02 | 9 |
hsa0124011 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa001301 | Oral cavity | OSCC | Ubiquinone and other terpenoid-quinone biosynthesis | 9/3704 | 11/8465 | 1.19e-02 | 2.62e-02 | 1.33e-02 | 9 |
hsa001302 | Oral cavity | LP | Ubiquinone and other terpenoid-quinone biosynthesis | 8/2418 | 11/8465 | 3.03e-03 | 1.29e-02 | 8.35e-03 | 8 |
hsa0124021 | Oral cavity | LP | Biosynthesis of cofactors | 57/2418 | 153/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 57 |
hsa001303 | Oral cavity | LP | Ubiquinone and other terpenoid-quinone biosynthesis | 8/2418 | 11/8465 | 3.03e-03 | 1.29e-02 | 8.35e-03 | 8 |
hsa0124031 | Oral cavity | LP | Biosynthesis of cofactors | 57/2418 | 153/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 57 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GGCX | SNV | Missense_Mutation | novel | c.1114C>A | p.Leu372Met | p.L372M | P38435 | protein_coding | tolerated(0.17) | benign(0.209) | TCGA-AR-A0TR-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
GGCX | SNV | Missense_Mutation | novel | c.1190A>G | p.Tyr397Cys | p.Y397C | P38435 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A0EB-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
GGCX | SNV | Missense_Mutation | novel | c.2242N>A | p.Glu748Lys | p.E748K | P38435 | protein_coding | tolerated_low_confidence(0.08) | benign(0.001) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
GGCX | insertion | Nonsense_Mutation | novel | c.1558_1559insGCCAAATCTGTTTTCATT | p.Lys520delinsSerGlnIleCysPheHisTer | p.K520delinsSQICFH* | P38435 | protein_coding | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
GGCX | insertion | Frame_Shift_Ins | novel | c.1188_1189insAGGAGGCTGAGGCATGAGAATCGCT | p.Tyr397ArgfsTer29 | p.Y397Rfs*29 | P38435 | protein_coding | TCGA-BH-A0EB-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
GGCX | insertion | Frame_Shift_Ins | novel | c.993_994insA | p.Pro332ThrfsTer15 | p.P332Tfs*15 | P38435 | protein_coding | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | ||
GGCX | insertion | In_Frame_Ins | novel | c.992_993insTTATACGAAGATATTTCCTTTTCTACCATT | p.Leu330_Leu331insPheTyrThrLysIlePheProPheLeuPro | p.L330_L331insFYTKIFPFLP | P38435 | protein_coding | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | ||
GGCX | SNV | Missense_Mutation | rs773659201 | c.1453C>T | p.Arg485Cys | p.R485C | P38435 | protein_coding | deleterious(0.01) | possibly_damaging(0.773) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GGCX | SNV | Missense_Mutation | c.787N>C | p.Asp263His | p.D263H | P38435 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
GGCX | SNV | Missense_Mutation | novel | c.193N>A | p.Ala65Thr | p.A65T | P38435 | protein_coding | deleterious(0) | possibly_damaging(0.833) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2677 | GGCX | DRUGGABLE GENOME, ENZYME | PHYTONADIONE | PHYTONADIONE | ||
2677 | GGCX | DRUGGABLE GENOME, ENZYME | ANISINDIONE | ANISINDIONE | ||
2677 | GGCX | DRUGGABLE GENOME, ENZYME | ANISINDIONE | ANISINDIONE | ||
2677 | GGCX | DRUGGABLE GENOME, ENZYME | MENADIONE | MENADIONE | ||
2677 | GGCX | DRUGGABLE GENOME, ENZYME | PHYTONADIONE | PHYTONADIONE | ||
2677 | GGCX | DRUGGABLE GENOME, ENZYME | Phytonadione | PHYTONADIONE | ||
2677 | GGCX | DRUGGABLE GENOME, ENZYME | inhibitor | 178103541 | ANISINDIONE | |
2677 | GGCX | DRUGGABLE GENOME, ENZYME | MENADIONE | MENADIONE | ||
2677 | GGCX | DRUGGABLE GENOME, ENZYME | acenocoumarol | ACENOCOUMAROL | 25042728,25519826,24927344,29432897 |
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