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Gene: GEMIN7 |
Gene summary for GEMIN7 |
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Gene information | Species | Human | Gene symbol | GEMIN7 | Gene ID | 79760 |
Gene name | gem nuclear organelle associated protein 7 | |
Gene Alias | SIP3 | |
Cytomap | 19q13.32 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | Q9H840 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79760 | GEMIN7 | P52T-E | Human | Esophagus | ESCC | 1.17e-33 | 5.56e-01 | 0.1555 |
79760 | GEMIN7 | P54T-E | Human | Esophagus | ESCC | 6.78e-17 | 3.77e-01 | 0.0975 |
79760 | GEMIN7 | P56T-E | Human | Esophagus | ESCC | 2.67e-08 | 6.20e-01 | 0.1613 |
79760 | GEMIN7 | P57T-E | Human | Esophagus | ESCC | 2.02e-10 | 1.01e-01 | 0.0926 |
79760 | GEMIN7 | P61T-E | Human | Esophagus | ESCC | 1.09e-13 | 1.64e-01 | 0.099 |
79760 | GEMIN7 | P62T-E | Human | Esophagus | ESCC | 1.23e-20 | 3.57e-01 | 0.1302 |
79760 | GEMIN7 | P65T-E | Human | Esophagus | ESCC | 2.07e-18 | 3.82e-01 | 0.0978 |
79760 | GEMIN7 | P74T-E | Human | Esophagus | ESCC | 7.15e-19 | 5.30e-01 | 0.1479 |
79760 | GEMIN7 | P75T-E | Human | Esophagus | ESCC | 1.38e-26 | 4.27e-01 | 0.1125 |
79760 | GEMIN7 | P76T-E | Human | Esophagus | ESCC | 1.64e-23 | 4.91e-01 | 0.1207 |
79760 | GEMIN7 | P79T-E | Human | Esophagus | ESCC | 7.21e-31 | 5.46e-01 | 0.1154 |
79760 | GEMIN7 | P80T-E | Human | Esophagus | ESCC | 1.79e-10 | 3.24e-01 | 0.155 |
79760 | GEMIN7 | P82T-E | Human | Esophagus | ESCC | 3.35e-15 | 7.38e-01 | 0.1072 |
79760 | GEMIN7 | P83T-E | Human | Esophagus | ESCC | 6.40e-30 | 1.10e+00 | 0.1738 |
79760 | GEMIN7 | P84T-E | Human | Esophagus | ESCC | 2.92e-05 | 3.30e-01 | 0.0933 |
79760 | GEMIN7 | P89T-E | Human | Esophagus | ESCC | 9.54e-27 | 1.09e+00 | 0.1752 |
79760 | GEMIN7 | P91T-E | Human | Esophagus | ESCC | 7.70e-10 | 9.90e-01 | 0.1828 |
79760 | GEMIN7 | P107T-E | Human | Esophagus | ESCC | 1.23e-31 | 7.71e-01 | 0.171 |
79760 | GEMIN7 | P126T-E | Human | Esophagus | ESCC | 2.63e-02 | 3.11e-01 | 0.1125 |
79760 | GEMIN7 | P127T-E | Human | Esophagus | ESCC | 5.22e-18 | 1.59e-01 | 0.0826 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0071826111 | Esophagus | ESCC | ribonucleoprotein complex subunit organization | 166/8552 | 227/18723 | 2.94e-17 | 2.42e-15 | 166 |
GO:0022618111 | Esophagus | ESCC | ribonucleoprotein complex assembly | 159/8552 | 220/18723 | 8.19e-16 | 5.71e-14 | 159 |
GO:00003875 | Esophagus | ESCC | spliceosomal snRNP assembly | 32/8552 | 50/18723 | 6.90e-03 | 2.52e-02 | 32 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
GO:000037522 | Liver | HCC | RNA splicing, via transesterification reactions | 228/7958 | 324/18723 | 1.47e-24 | 4.06e-22 | 228 |
GO:000037722 | Liver | HCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
GO:000039822 | Liver | HCC | mRNA splicing, via spliceosome | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
GO:007182622 | Liver | HCC | ribonucleoprotein complex subunit organization | 159/7958 | 227/18723 | 3.14e-17 | 3.06e-15 | 159 |
GO:002261822 | Liver | HCC | ribonucleoprotein complex assembly | 153/7958 | 220/18723 | 3.44e-16 | 2.91e-14 | 153 |
GO:00003872 | Liver | HCC | spliceosomal snRNP assembly | 31/7958 | 50/18723 | 4.23e-03 | 1.84e-02 | 31 |
GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
GO:000838020 | Oral cavity | OSCC | RNA splicing | 308/7305 | 434/18723 | 2.43e-42 | 7.70e-39 | 308 |
GO:000037519 | Oral cavity | OSCC | RNA splicing, via transesterification reactions | 225/7305 | 324/18723 | 5.20e-29 | 2.99e-26 | 225 |
GO:000037719 | Oral cavity | OSCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 221/7305 | 320/18723 | 5.50e-28 | 2.18e-25 | 221 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GEMIN7 | SNV | Missense_Mutation | rs771062286 | c.169C>T | p.Arg57Trp | p.R57W | Q9H840 | protein_coding | tolerated(0.13) | possibly_damaging(0.751) | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GEMIN7 | SNV | Missense_Mutation | novel | c.10C>A | p.Pro4Thr | p.P4T | Q9H840 | protein_coding | deleterious(0.01) | benign(0.037) | TCGA-GM-A3XN-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | CR |
GEMIN7 | SNV | Missense_Mutation | novel | c.193N>T | p.Arg65Cys | p.R65C | Q9H840 | protein_coding | deleterious(0.05) | probably_damaging(0.96) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GEMIN7 | SNV | Missense_Mutation | novel | c.367G>A | p.Asp123Asn | p.D123N | Q9H840 | protein_coding | deleterious(0) | possibly_damaging(0.831) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
GEMIN7 | SNV | Missense_Mutation | c.224N>A | p.Gly75Asp | p.G75D | Q9H840 | protein_coding | tolerated(0.14) | possibly_damaging(0.595) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GEMIN7 | SNV | Missense_Mutation | rs754626287 | c.259N>T | p.Arg87Cys | p.R87C | Q9H840 | protein_coding | tolerated(0.12) | possibly_damaging(0.567) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
GEMIN7 | SNV | Missense_Mutation | rs549005908 | c.370A>G | p.Ile124Val | p.I124V | Q9H840 | protein_coding | tolerated(0.54) | benign(0.084) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GEMIN7 | SNV | Missense_Mutation | rs539996423 | c.203G>A | p.Arg68His | p.R68H | Q9H840 | protein_coding | tolerated(0.07) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
GEMIN7 | SNV | Missense_Mutation | rs763042171 | c.359N>A | p.Arg120Gln | p.R120Q | Q9H840 | protein_coding | deleterious(0.04) | possibly_damaging(0.904) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
GEMIN7 | SNV | Missense_Mutation | rs745702182 | c.286N>A | p.Asp96Asn | p.D96N | Q9H840 | protein_coding | tolerated(0.06) | probably_damaging(1) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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