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Gene: GCAT |
Gene summary for GCAT |
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Gene information | Species | Human | Gene symbol | GCAT | Gene ID | 23464 |
Gene name | glycine C-acetyltransferase | |
Gene Alias | KBL | |
Cytomap | 22q13.1 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | O75600 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23464 | GCAT | P62T-E | Human | Esophagus | ESCC | 2.67e-26 | 5.03e-01 | 0.1302 |
23464 | GCAT | P65T-E | Human | Esophagus | ESCC | 4.28e-40 | 8.29e-01 | 0.0978 |
23464 | GCAT | P74T-E | Human | Esophagus | ESCC | 1.15e-19 | 5.89e-01 | 0.1479 |
23464 | GCAT | P75T-E | Human | Esophagus | ESCC | 1.85e-18 | 3.45e-01 | 0.1125 |
23464 | GCAT | P76T-E | Human | Esophagus | ESCC | 5.21e-52 | 1.03e+00 | 0.1207 |
23464 | GCAT | P79T-E | Human | Esophagus | ESCC | 4.38e-15 | 3.05e-01 | 0.1154 |
23464 | GCAT | P80T-E | Human | Esophagus | ESCC | 3.16e-10 | 3.72e-01 | 0.155 |
23464 | GCAT | P82T-E | Human | Esophagus | ESCC | 4.85e-09 | 5.74e-01 | 0.1072 |
23464 | GCAT | P84T-E | Human | Esophagus | ESCC | 1.11e-03 | 3.56e-01 | 0.0933 |
23464 | GCAT | P89T-E | Human | Esophagus | ESCC | 3.32e-20 | 1.03e+00 | 0.1752 |
23464 | GCAT | P91T-E | Human | Esophagus | ESCC | 8.91e-07 | 7.29e-01 | 0.1828 |
23464 | GCAT | P104T-E | Human | Esophagus | ESCC | 5.18e-05 | 4.35e-01 | 0.0931 |
23464 | GCAT | P107T-E | Human | Esophagus | ESCC | 4.64e-23 | 5.22e-01 | 0.171 |
23464 | GCAT | P126T-E | Human | Esophagus | ESCC | 5.71e-05 | 2.89e-01 | 0.1125 |
23464 | GCAT | P127T-E | Human | Esophagus | ESCC | 1.06e-06 | 1.29e-01 | 0.0826 |
23464 | GCAT | P128T-E | Human | Esophagus | ESCC | 6.47e-60 | 1.96e+00 | 0.1241 |
23464 | GCAT | P130T-E | Human | Esophagus | ESCC | 2.31e-85 | 1.53e+00 | 0.1676 |
23464 | GCAT | HCC1_Meng | Human | Liver | HCC | 3.01e-59 | 2.39e-01 | 0.0246 |
23464 | GCAT | HCC2_Meng | Human | Liver | HCC | 1.97e-03 | 3.19e-02 | 0.0107 |
23464 | GCAT | HCC1 | Human | Liver | HCC | 4.34e-19 | 4.29e+00 | 0.5336 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00442827 | Esophagus | ESCC | small molecule catabolic process | 201/8552 | 376/18723 | 1.35e-03 | 6.41e-03 | 201 |
GO:004428221 | Liver | HCC | small molecule catabolic process | 225/7958 | 376/18723 | 6.50e-12 | 2.80e-10 | 225 |
GO:001605421 | Liver | HCC | organic acid catabolic process | 152/7958 | 240/18723 | 5.11e-11 | 1.92e-09 | 152 |
GO:00463952 | Liver | HCC | carboxylic acid catabolic process | 149/7958 | 236/18723 | 1.11e-10 | 3.87e-09 | 149 |
GO:19016052 | Liver | HCC | alpha-amino acid metabolic process | 124/7958 | 195/18723 | 2.07e-09 | 5.79e-08 | 124 |
GO:00065202 | Liver | HCC | cellular amino acid metabolic process | 167/7958 | 284/18723 | 1.91e-08 | 4.56e-07 | 167 |
GO:00090632 | Liver | HCC | cellular amino acid catabolic process | 70/7958 | 110/18723 | 6.12e-06 | 7.52e-05 | 70 |
GO:00090692 | Liver | HCC | serine family amino acid metabolic process | 29/7958 | 40/18723 | 1.17e-04 | 9.87e-04 | 29 |
GO:00090662 | Liver | HCC | aspartate family amino acid metabolic process | 34/7958 | 49/18723 | 1.28e-04 | 1.06e-03 | 34 |
GO:19016062 | Liver | HCC | alpha-amino acid catabolic process | 53/7958 | 87/18723 | 4.01e-04 | 2.71e-03 | 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa002602 | Liver | HCC | Glycine, serine and threonine metabolism | 28/4020 | 40/8465 | 3.28e-03 | 1.07e-02 | 5.93e-03 | 28 |
hsa002603 | Liver | HCC | Glycine, serine and threonine metabolism | 28/4020 | 40/8465 | 3.28e-03 | 1.07e-02 | 5.93e-03 | 28 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GCAT | SNV | Missense_Mutation | c.325G>A | p.Glu109Lys | p.E109K | O75600 | protein_coding | tolerated(0.16) | benign(0.021) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
GCAT | SNV | Missense_Mutation | rs201266387 | c.607C>T | p.Arg203Cys | p.R203C | O75600 | protein_coding | deleterious(0.02) | benign(0.013) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GCAT | SNV | Missense_Mutation | c.332N>C | p.Ile111Thr | p.I111T | O75600 | protein_coding | deleterious(0.02) | possibly_damaging(0.612) | TCGA-C8-A26X-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
GCAT | SNV | Missense_Mutation | novel | c.308N>A | p.Gly103Asp | p.G103D | O75600 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
GCAT | SNV | Missense_Mutation | novel | c.65N>T | p.Ser22Leu | p.S22L | O75600 | protein_coding | deleterious_low_confidence(0.01) | benign(0.169) | TCGA-EX-A69L-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
GCAT | SNV | Missense_Mutation | novel | c.155N>T | p.Ser52Phe | p.S52F | O75600 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GCAT | SNV | Missense_Mutation | rs750055272 | c.1070N>A | p.Arg357His | p.R357H | O75600 | protein_coding | deleterious(0.03) | probably_damaging(0.995) | TCGA-VS-A9V1-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
GCAT | SNV | Missense_Mutation | rs200392738 | c.809N>A | p.Arg270Gln | p.R270Q | O75600 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
GCAT | SNV | Missense_Mutation | rs139816860 | c.1216N>A | p.Val406Met | p.V406M | O75600 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GCAT | SNV | Missense_Mutation | novel | c.493G>A | p.Ala165Thr | p.A165T | O75600 | protein_coding | tolerated(0.14) | benign(0.176) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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