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Gene: GADD45GIP1 |
Gene summary for GADD45GIP1 |
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Gene information | Species | Human | Gene symbol | GADD45GIP1 | Gene ID | 90480 |
Gene name | GADD45G interacting protein 1 | |
Gene Alias | CKBBP2 | |
Cytomap | 19p13.13 | |
Gene Type | protein-coding | GO ID | GO:0007049 | UniProtAcc | Q8TAE8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90480 | GADD45GIP1 | L1 | Human | Cervix | CC | 1.02e-03 | -1.78e-01 | 0.0802 |
90480 | GADD45GIP1 | AEH-subject1 | Human | Endometrium | AEH | 9.25e-06 | -1.69e-01 | -0.3059 |
90480 | GADD45GIP1 | AEH-subject2 | Human | Endometrium | AEH | 6.78e-07 | -9.46e-02 | -0.2525 |
90480 | GADD45GIP1 | AEH-subject3 | Human | Endometrium | AEH | 2.04e-07 | -7.55e-02 | -0.2576 |
90480 | GADD45GIP1 | AEH-subject4 | Human | Endometrium | AEH | 1.11e-11 | -3.77e-01 | -0.2657 |
90480 | GADD45GIP1 | AEH-subject5 | Human | Endometrium | AEH | 3.50e-13 | -3.95e-01 | -0.2953 |
90480 | GADD45GIP1 | EEC-subject1 | Human | Endometrium | EEC | 1.16e-21 | -4.49e-01 | -0.2682 |
90480 | GADD45GIP1 | EEC-subject2 | Human | Endometrium | EEC | 1.10e-13 | 6.52e-02 | -0.2607 |
90480 | GADD45GIP1 | EEC-subject3 | Human | Endometrium | EEC | 3.08e-52 | -5.80e-01 | -0.2525 |
90480 | GADD45GIP1 | EEC-subject4 | Human | Endometrium | EEC | 6.98e-07 | -2.18e-01 | -0.2571 |
90480 | GADD45GIP1 | EEC-subject5 | Human | Endometrium | EEC | 8.85e-12 | -2.53e-01 | -0.249 |
90480 | GADD45GIP1 | GSM5276934 | Human | Endometrium | EEC | 1.32e-09 | -3.08e-01 | -0.0913 |
90480 | GADD45GIP1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.06e-34 | -5.96e-01 | -0.1869 |
90480 | GADD45GIP1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 3.22e-33 | -5.95e-01 | -0.1875 |
90480 | GADD45GIP1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.11e-40 | -6.08e-01 | -0.1883 |
90480 | GADD45GIP1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 8.22e-46 | -6.47e-01 | -0.1934 |
90480 | GADD45GIP1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.63e-60 | -6.69e-01 | -0.1917 |
90480 | GADD45GIP1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.07e-54 | -7.07e-01 | -0.1916 |
90480 | GADD45GIP1 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 4.69e-17 | -4.24e-01 | -0.1269 |
90480 | GADD45GIP1 | LZE4T | Human | Esophagus | ESCC | 6.69e-15 | 5.41e-01 | 0.0811 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GADD45GIP1 | SNV | Missense_Mutation | novel | c.47N>T | p.Ala16Val | p.A16V | Q8TAE8 | protein_coding | tolerated(0.58) | benign(0.007) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GADD45GIP1 | deletion | Frame_Shift_Del | rs752340689 | c.585_586delNN | p.Lys196ThrfsTer43 | p.K196Tfs*43 | Q8TAE8 | protein_coding | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
GADD45GIP1 | SNV | Missense_Mutation | novel | c.301N>A | p.Glu101Lys | p.E101K | Q8TAE8 | protein_coding | tolerated(0.3) | benign(0.23) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GADD45GIP1 | SNV | Missense_Mutation | novel | c.184N>A | p.Ala62Thr | p.A62T | Q8TAE8 | protein_coding | deleterious(0) | benign(0.023) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GADD45GIP1 | SNV | Missense_Mutation | rs147251319 | c.566G>A | p.Arg189His | p.R189H | Q8TAE8 | protein_coding | tolerated(0.07) | probably_damaging(0.945) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
GADD45GIP1 | SNV | Missense_Mutation | rs779779033 | c.560G>A | p.Arg187His | p.R187H | Q8TAE8 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GADD45GIP1 | SNV | Missense_Mutation | rs763367169 | c.521N>A | p.Arg174His | p.R174H | Q8TAE8 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GADD45GIP1 | SNV | Missense_Mutation | novel | c.585N>T | p.Gln195His | p.Q195H | Q8TAE8 | protein_coding | deleterious(0.01) | possibly_damaging(0.855) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GADD45GIP1 | SNV | Missense_Mutation | rs753799047 | c.559C>T | p.Arg187Cys | p.R187C | Q8TAE8 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GADD45GIP1 | SNV | Missense_Mutation | rs755977311 | c.565N>T | p.Arg189Cys | p.R189C | Q8TAE8 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-EY-A1H0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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