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Gene: FLYWCH2 |
Gene summary for FLYWCH2 |
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Gene information | Species | Human | Gene symbol | FLYWCH2 | Gene ID | 114984 |
Gene name | FLYWCH family member 2 | |
Gene Alias | FLYWCH2 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q96CP2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114984 | FLYWCH2 | P42T-E | Human | Esophagus | ESCC | 2.78e-29 | 6.73e-01 | 0.1175 |
114984 | FLYWCH2 | P44T-E | Human | Esophagus | ESCC | 1.88e-21 | 4.24e-01 | 0.1096 |
114984 | FLYWCH2 | P47T-E | Human | Esophagus | ESCC | 1.06e-26 | 5.70e-01 | 0.1067 |
114984 | FLYWCH2 | P48T-E | Human | Esophagus | ESCC | 5.06e-28 | 4.86e-01 | 0.0959 |
114984 | FLYWCH2 | P49T-E | Human | Esophagus | ESCC | 2.14e-15 | 1.39e+00 | 0.1768 |
114984 | FLYWCH2 | P52T-E | Human | Esophagus | ESCC | 3.84e-39 | 7.09e-01 | 0.1555 |
114984 | FLYWCH2 | P54T-E | Human | Esophagus | ESCC | 2.06e-38 | 7.04e-01 | 0.0975 |
114984 | FLYWCH2 | P56T-E | Human | Esophagus | ESCC | 9.38e-09 | 6.39e-01 | 0.1613 |
114984 | FLYWCH2 | P57T-E | Human | Esophagus | ESCC | 2.40e-37 | 7.40e-01 | 0.0926 |
114984 | FLYWCH2 | P61T-E | Human | Esophagus | ESCC | 9.50e-34 | 7.70e-01 | 0.099 |
114984 | FLYWCH2 | P62T-E | Human | Esophagus | ESCC | 2.47e-88 | 1.26e+00 | 0.1302 |
114984 | FLYWCH2 | P65T-E | Human | Esophagus | ESCC | 6.86e-52 | 8.41e-01 | 0.0978 |
114984 | FLYWCH2 | P74T-E | Human | Esophagus | ESCC | 5.47e-32 | 7.91e-01 | 0.1479 |
114984 | FLYWCH2 | P75T-E | Human | Esophagus | ESCC | 1.00e-72 | 1.27e+00 | 0.1125 |
114984 | FLYWCH2 | P76T-E | Human | Esophagus | ESCC | 2.06e-46 | 7.38e-01 | 0.1207 |
114984 | FLYWCH2 | P79T-E | Human | Esophagus | ESCC | 6.04e-63 | 1.11e+00 | 0.1154 |
114984 | FLYWCH2 | P80T-E | Human | Esophagus | ESCC | 1.80e-52 | 1.36e+00 | 0.155 |
114984 | FLYWCH2 | P82T-E | Human | Esophagus | ESCC | 4.85e-19 | 8.46e-01 | 0.1072 |
114984 | FLYWCH2 | P83T-E | Human | Esophagus | ESCC | 2.28e-52 | 1.29e+00 | 0.1738 |
114984 | FLYWCH2 | P84T-E | Human | Esophagus | ESCC | 1.04e-19 | 8.20e-01 | 0.0933 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FLYWCH2 | insertion | In_Frame_Ins | novel | c.119_120insGTTGGGGCCTCCCGTAACTCTTTA | p.Ser40_Lys41insLeuGlyProProValThrLeuTyr | p.S40_K41insLGPPVTLY | Q96CP2 | protein_coding | TCGA-A7-A0CG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FLYWCH2 | SNV | Missense_Mutation | rs566687400 | c.356N>T | p.Ala119Val | p.A119V | Q96CP2 | protein_coding | tolerated_low_confidence(0.46) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FLYWCH2 | SNV | Missense_Mutation | novel | c.163G>A | p.Ala55Thr | p.A55T | Q96CP2 | protein_coding | tolerated(0.15) | benign(0.325) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FLYWCH2 | SNV | Missense_Mutation | rs376595971 | c.404N>T | p.Ala135Val | p.A135V | Q96CP2 | protein_coding | tolerated_low_confidence(0.44) | benign(0.003) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FLYWCH2 | SNV | Missense_Mutation | c.127G>A | p.Val43Ile | p.V43I | Q96CP2 | protein_coding | deleterious(0.02) | possibly_damaging(0.893) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FLYWCH2 | SNV | Missense_Mutation | rs770341502 | c.175N>T | p.Arg59Cys | p.R59C | Q96CP2 | protein_coding | tolerated(0.11) | probably_damaging(0.988) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FLYWCH2 | SNV | Missense_Mutation | novel | c.383A>G | p.Asn128Ser | p.N128S | Q96CP2 | protein_coding | tolerated_low_confidence(0.68) | benign(0.006) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
FLYWCH2 | SNV | Missense_Mutation | c.31N>A | p.Gly11Ser | p.G11S | Q96CP2 | protein_coding | tolerated(0.09) | benign(0.14) | TCGA-DD-A4NJ-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
FLYWCH2 | SNV | Missense_Mutation | c.31N>T | p.Gly11Cys | p.G11C | Q96CP2 | protein_coding | deleterious(0) | possibly_damaging(0.821) | TCGA-64-1676-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FLYWCH2 | SNV | Missense_Mutation | c.32N>T | p.Gly11Val | p.G11V | Q96CP2 | protein_coding | deleterious(0) | benign(0.258) | TCGA-64-1676-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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