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Gene: FAM83C |
Gene summary for FAM83C |
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Gene information | Species | Human | Gene symbol | FAM83C | Gene ID | 128876 |
Gene name | family with sequence similarity 83 member C | |
Gene Alias | C20orf128 | |
Cytomap | 20q11.22 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q9BQN1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
128876 | FAM83C | C57 | Human | Oral cavity | OSCC | 7.37e-07 | 4.24e-01 | 0.1679 |
128876 | FAM83C | C08 | Human | Oral cavity | OSCC | 1.51e-09 | 1.10e-01 | 0.1919 |
128876 | FAM83C | LN22 | Human | Oral cavity | OSCC | 7.35e-07 | 7.74e-01 | 0.1733 |
128876 | FAM83C | LP15 | Human | Oral cavity | LP | 1.93e-03 | 5.29e-01 | 0.2174 |
128876 | FAM83C | SYSMH1 | Human | Oral cavity | OSCC | 7.76e-04 | 1.28e-01 | 0.1127 |
128876 | FAM83C | SYSMH2 | Human | Oral cavity | OSCC | 7.44e-04 | 1.25e-01 | 0.2326 |
128876 | FAM83C | SYSMH3 | Human | Oral cavity | OSCC | 4.12e-07 | 2.54e-01 | 0.2442 |
128876 | FAM83C | SYSMH4 | Human | Oral cavity | OSCC | 8.04e-04 | 8.89e-02 | 0.1226 |
128876 | FAM83C | SYSMH5 | Human | Oral cavity | OSCC | 7.99e-06 | 1.05e-01 | 0.0647 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM83C | SNV | Missense_Mutation | rs149089081 | c.512N>T | p.Thr171Met | p.T171M | Q9BQN1 | protein_coding | deleterious(0.03) | benign(0.092) | TCGA-A7-A6VV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
FAM83C | SNV | Missense_Mutation | rs374408772 | c.967N>T | p.Arg323Cys | p.R323C | Q9BQN1 | protein_coding | tolerated(0.09) | benign(0) | TCGA-AC-A4ZE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM83C | SNV | Missense_Mutation | c.1414N>A | p.Gly472Arg | p.G472R | Q9BQN1 | protein_coding | deleterious_low_confidence(0.04) | benign(0.001) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
FAM83C | SNV | Missense_Mutation | novel | c.1710G>T | p.Leu570Phe | p.L570F | Q9BQN1 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-OL-A6VQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM83C | insertion | Frame_Shift_Ins | novel | c.405_406insGGTGTCAGGGACT | p.Pro136GlyfsTer51 | p.P136Gfs*51 | Q9BQN1 | protein_coding | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
FAM83C | SNV | Missense_Mutation | c.277G>C | p.Glu93Gln | p.E93Q | Q9BQN1 | protein_coding | deleterious(0.04) | possibly_damaging(0.469) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD | |
FAM83C | SNV | Missense_Mutation | novel | c.253N>C | p.Val85Leu | p.V85L | Q9BQN1 | protein_coding | tolerated(0.17) | benign(0.138) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
FAM83C | SNV | Missense_Mutation | rs373959129 | c.1093N>G | p.Leu365Val | p.L365V | Q9BQN1 | protein_coding | tolerated_low_confidence(0.06) | benign(0.11) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
FAM83C | SNV | Missense_Mutation | novel | c.1053N>G | p.Ile351Met | p.I351M | Q9BQN1 | protein_coding | deleterious(0.01) | benign(0.219) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FAM83C | SNV | Missense_Mutation | c.1201C>T | p.Pro401Ser | p.P401S | Q9BQN1 | protein_coding | tolerated_low_confidence(0.13) | benign(0.234) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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