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Gene: FAM114A1 |
Gene summary for FAM114A1 |
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Gene information | Species | Human | Gene symbol | FAM114A1 | Gene ID | 92689 |
Gene name | family with sequence similarity 114 member A1 | |
Gene Alias | Noxp20 | |
Cytomap | 4p14 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8IWE2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
92689 | FAM114A1 | P16T-E | Human | Esophagus | ESCC | 2.04e-33 | 7.20e-01 | 0.1153 |
92689 | FAM114A1 | P17T-E | Human | Esophagus | ESCC | 3.71e-14 | 8.63e-01 | 0.1278 |
92689 | FAM114A1 | P19T-E | Human | Esophagus | ESCC | 6.67e-16 | 1.61e+00 | 0.1662 |
92689 | FAM114A1 | P20T-E | Human | Esophagus | ESCC | 1.19e-16 | 4.99e-01 | 0.1124 |
92689 | FAM114A1 | P21T-E | Human | Esophagus | ESCC | 1.98e-46 | 9.58e-01 | 0.1617 |
92689 | FAM114A1 | P22T-E | Human | Esophagus | ESCC | 1.99e-15 | 3.50e-01 | 0.1236 |
92689 | FAM114A1 | P23T-E | Human | Esophagus | ESCC | 3.33e-31 | 9.38e-01 | 0.108 |
92689 | FAM114A1 | P24T-E | Human | Esophagus | ESCC | 2.27e-29 | 8.01e-01 | 0.1287 |
92689 | FAM114A1 | P26T-E | Human | Esophagus | ESCC | 3.90e-09 | 2.48e-01 | 0.1276 |
92689 | FAM114A1 | P27T-E | Human | Esophagus | ESCC | 1.56e-23 | 4.55e-01 | 0.1055 |
92689 | FAM114A1 | P28T-E | Human | Esophagus | ESCC | 8.52e-12 | 3.05e-01 | 0.1149 |
92689 | FAM114A1 | P30T-E | Human | Esophagus | ESCC | 1.39e-20 | 9.93e-01 | 0.137 |
92689 | FAM114A1 | P31T-E | Human | Esophagus | ESCC | 1.09e-39 | 7.98e-01 | 0.1251 |
92689 | FAM114A1 | P32T-E | Human | Esophagus | ESCC | 1.07e-77 | 1.52e+00 | 0.1666 |
92689 | FAM114A1 | P36T-E | Human | Esophagus | ESCC | 3.94e-19 | 6.71e-01 | 0.1187 |
92689 | FAM114A1 | P37T-E | Human | Esophagus | ESCC | 1.29e-26 | 6.74e-01 | 0.1371 |
92689 | FAM114A1 | P38T-E | Human | Esophagus | ESCC | 3.71e-10 | 5.06e-01 | 0.127 |
92689 | FAM114A1 | P39T-E | Human | Esophagus | ESCC | 9.23e-19 | 4.90e-01 | 0.0894 |
92689 | FAM114A1 | P40T-E | Human | Esophagus | ESCC | 1.25e-15 | 6.66e-01 | 0.109 |
92689 | FAM114A1 | P42T-E | Human | Esophagus | ESCC | 4.84e-13 | 6.35e-01 | 0.1175 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM114A1 | SNV | Missense_Mutation | c.19G>A | p.Asp7Asn | p.D7N | Q8IWE2 | protein_coding | tolerated_low_confidence(0.09) | benign(0.019) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
FAM114A1 | SNV | Missense_Mutation | c.713N>A | p.Thr238Asn | p.T238N | Q8IWE2 | protein_coding | deleterious(0) | possibly_damaging(0.554) | TCGA-E2-A15M-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
FAM114A1 | SNV | Missense_Mutation | c.547N>A | p.Glu183Lys | p.E183K | Q8IWE2 | protein_coding | tolerated(0.31) | benign(0.009) | TCGA-E2-A1IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
FAM114A1 | insertion | Frame_Shift_Ins | novel | c.512_513insCAGCCACTTTGGACCATCCGTAGGCT | p.Glu171AspfsTer10 | p.E171Dfs*10 | Q8IWE2 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
FAM114A1 | deletion | Frame_Shift_Del | novel | c.782delN | p.Leu262CysfsTer5 | p.L262Cfs*5 | Q8IWE2 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
FAM114A1 | SNV | Missense_Mutation | novel | c.1240G>A | p.Glu414Lys | p.E414K | Q8IWE2 | protein_coding | tolerated(0.82) | benign(0.001) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
FAM114A1 | SNV | Missense_Mutation | c.1688C>T | p.Pro563Leu | p.P563L | Q8IWE2 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-VS-A9UD-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
FAM114A1 | SNV | Missense_Mutation | c.334N>A | p.Glu112Lys | p.E112K | Q8IWE2 | protein_coding | deleterious(0.05) | benign(0.197) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FAM114A1 | SNV | Missense_Mutation | rs143144596 | c.937N>A | p.Glu313Lys | p.E313K | Q8IWE2 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
FAM114A1 | SNV | Missense_Mutation | rs149201693 | c.319N>A | p.Glu107Lys | p.E107K | Q8IWE2 | protein_coding | tolerated(0.05) | benign(0.263) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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