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Gene: FAAP20 |
Gene summary for FAAP20 |
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Gene information | Species | Human | Gene symbol | FAAP20 | Gene ID | 199990 |
Gene name | FA core complex associated protein 20 | |
Gene Alias | C1orf86 | |
Cytomap | 1p36.33 | |
Gene Type | protein-coding | GO ID | GO:0000731 | UniProtAcc | Q6ZRT9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
199990 | FAAP20 | P15T-E | Human | Esophagus | ESCC | 3.22e-78 | 1.54e+00 | 0.1149 |
199990 | FAAP20 | P16T-E | Human | Esophagus | ESCC | 1.61e-57 | 1.13e+00 | 0.1153 |
199990 | FAAP20 | P17T-E | Human | Esophagus | ESCC | 3.40e-22 | 1.01e+00 | 0.1278 |
199990 | FAAP20 | P19T-E | Human | Esophagus | ESCC | 1.14e-23 | 1.75e+00 | 0.1662 |
199990 | FAAP20 | P20T-E | Human | Esophagus | ESCC | 7.74e-54 | 1.18e+00 | 0.1124 |
199990 | FAAP20 | P21T-E | Human | Esophagus | ESCC | 3.00e-104 | 2.12e+00 | 0.1617 |
199990 | FAAP20 | P22T-E | Human | Esophagus | ESCC | 2.35e-69 | 1.19e+00 | 0.1236 |
199990 | FAAP20 | P23T-E | Human | Esophagus | ESCC | 1.06e-50 | 1.13e+00 | 0.108 |
199990 | FAAP20 | P24T-E | Human | Esophagus | ESCC | 2.78e-50 | 1.08e+00 | 0.1287 |
199990 | FAAP20 | P26T-E | Human | Esophagus | ESCC | 4.95e-57 | 1.13e+00 | 0.1276 |
199990 | FAAP20 | P27T-E | Human | Esophagus | ESCC | 3.70e-85 | 1.48e+00 | 0.1055 |
199990 | FAAP20 | P28T-E | Human | Esophagus | ESCC | 7.20e-86 | 1.41e+00 | 0.1149 |
199990 | FAAP20 | P30T-E | Human | Esophagus | ESCC | 3.97e-58 | 1.75e+00 | 0.137 |
199990 | FAAP20 | P31T-E | Human | Esophagus | ESCC | 1.66e-76 | 1.42e+00 | 0.1251 |
199990 | FAAP20 | P32T-E | Human | Esophagus | ESCC | 2.60e-102 | 1.75e+00 | 0.1666 |
199990 | FAAP20 | P36T-E | Human | Esophagus | ESCC | 7.73e-29 | 8.39e-01 | 0.1187 |
199990 | FAAP20 | P37T-E | Human | Esophagus | ESCC | 9.72e-59 | 1.30e+00 | 0.1371 |
199990 | FAAP20 | P38T-E | Human | Esophagus | ESCC | 7.52e-15 | 6.36e-01 | 0.127 |
199990 | FAAP20 | P39T-E | Human | Esophagus | ESCC | 3.75e-36 | 8.06e-01 | 0.0894 |
199990 | FAAP20 | P40T-E | Human | Esophagus | ESCC | 1.26e-46 | 1.52e+00 | 0.109 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00718977 | Endometrium | AEH | DNA biosynthetic process | 37/2100 | 180/18723 | 1.87e-04 | 2.39e-03 | 37 |
GO:007189713 | Endometrium | EEC | DNA biosynthetic process | 39/2168 | 180/18723 | 7.68e-05 | 1.11e-03 | 39 |
GO:007189710 | Esophagus | HGIN | DNA biosynthetic process | 44/2587 | 180/18723 | 8.97e-05 | 1.96e-03 | 44 |
GO:007189716 | Esophagus | ESCC | DNA biosynthetic process | 127/8552 | 180/18723 | 1.04e-11 | 3.85e-10 | 127 |
GO:00063012 | Esophagus | ESCC | postreplication repair | 26/8552 | 31/18723 | 1.32e-05 | 1.21e-04 | 26 |
GO:0019985 | Esophagus | ESCC | translesion synthesis | 17/8552 | 21/18723 | 1.03e-03 | 5.19e-03 | 17 |
GO:0006301 | Liver | Cirrhotic | postreplication repair | 15/4634 | 31/18723 | 3.68e-03 | 2.02e-02 | 15 |
GO:00718975 | Liver | HCC | DNA biosynthetic process | 99/7958 | 180/18723 | 4.66e-04 | 3.08e-03 | 99 |
GO:00718979 | Oral cavity | OSCC | DNA biosynthetic process | 106/7305 | 180/18723 | 4.86e-08 | 8.95e-07 | 106 |
GO:00063011 | Oral cavity | OSCC | postreplication repair | 20/7305 | 31/18723 | 3.57e-03 | 1.49e-02 | 20 |
GO:007189715 | Oral cavity | LP | DNA biosynthetic process | 71/4623 | 180/18723 | 8.04e-06 | 1.52e-04 | 71 |
GO:00718974 | Stomach | CAG with IM | DNA biosynthetic process | 19/1050 | 180/18723 | 6.02e-03 | 4.63e-02 | 19 |
GO:007189711 | Stomach | CSG | DNA biosynthetic process | 19/1034 | 180/18723 | 5.12e-03 | 4.17e-02 | 19 |
GO:0071897110 | Thyroid | PTC | DNA biosynthetic process | 82/5968 | 180/18723 | 7.98e-05 | 6.81e-04 | 82 |
GO:00063013 | Thyroid | PTC | postreplication repair | 17/5968 | 31/18723 | 6.74e-03 | 2.90e-02 | 17 |
GO:007189723 | Thyroid | ATC | DNA biosynthetic process | 91/6293 | 180/18723 | 1.84e-06 | 2.24e-05 | 91 |
GO:000630111 | Thyroid | ATC | postreplication repair | 18/6293 | 31/18723 | 4.45e-03 | 1.84e-02 | 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAAP20 | deletion | Frame_Shift_Del | novel | c.88_92delCTGAA | p.Leu30ValfsTer95 | p.L30Vfs*95 | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |||
FAAP20 | SNV | Missense_Mutation | c.352N>G | p.Pro118Ala | p.P118A | protein_coding | probably_damaging(0.916) | TCGA-AA-3982-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |||
FAAP20 | SNV | Missense_Mutation | rs754746314 | c.565N>A | p.Ala189Thr | p.A189T | protein_coding | possibly_damaging(0.488) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FAAP20 | SNV | Missense_Mutation | c.509N>A | p.Arg170Gln | p.R170Q | protein_coding | benign(0.186) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |||
FAAP20 | SNV | Missense_Mutation | novel | c.412N>C | p.Trp138Arg | p.W138R | protein_coding | benign(0) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FAAP20 | SNV | Missense_Mutation | rs754595816 | c.539N>T | p.Pro180Leu | p.P180L | protein_coding | benign(0) | TCGA-D1-A174-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FAAP20 | SNV | Missense_Mutation | novel | c.290N>A | p.Arg97Gln | p.R97Q | protein_coding | benign(0.003) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | ||
FAAP20 | SNV | Missense_Mutation | novel | c.439G>A | p.Gly147Ser | p.G147S | protein_coding | possibly_damaging(0.871) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD | ||
FAAP20 | deletion | Frame_Shift_Del | novel | c.387delC | p.Tyr130ThrfsTer160 | p.Y130Tfs*160 | protein_coding | TCGA-BS-A0UA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
FAAP20 | deletion | Frame_Shift_Del | novel | c.387delN | p.Tyr130ThrfsTer160 | p.Y130Tfs*160 | protein_coding | TCGA-D1-A174-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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