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Gene: EIF2A |
Gene summary for EIF2A |
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Gene information | Species | Human | Gene symbol | EIF2A | Gene ID | 83939 |
Gene name | eukaryotic translation initiation factor 2A | |
Gene Alias | CDA02 | |
Cytomap | 3q25.1 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | Q9BY44 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83939 | EIF2A | P48T-E | Human | Esophagus | ESCC | 8.30e-25 | 7.67e-01 | 0.0959 |
83939 | EIF2A | P49T-E | Human | Esophagus | ESCC | 9.29e-12 | 1.43e+00 | 0.1768 |
83939 | EIF2A | P52T-E | Human | Esophagus | ESCC | 9.47e-36 | 1.33e+00 | 0.1555 |
83939 | EIF2A | P54T-E | Human | Esophagus | ESCC | 3.08e-31 | 1.00e+00 | 0.0975 |
83939 | EIF2A | P56T-E | Human | Esophagus | ESCC | 1.90e-13 | 2.23e+00 | 0.1613 |
83939 | EIF2A | P57T-E | Human | Esophagus | ESCC | 2.46e-23 | 6.36e-01 | 0.0926 |
83939 | EIF2A | P61T-E | Human | Esophagus | ESCC | 2.28e-13 | 5.78e-01 | 0.099 |
83939 | EIF2A | P62T-E | Human | Esophagus | ESCC | 2.84e-89 | 1.89e+00 | 0.1302 |
83939 | EIF2A | P65T-E | Human | Esophagus | ESCC | 4.67e-23 | 6.87e-01 | 0.0978 |
83939 | EIF2A | P74T-E | Human | Esophagus | ESCC | 1.29e-57 | 2.01e+00 | 0.1479 |
83939 | EIF2A | P75T-E | Human | Esophagus | ESCC | 5.30e-40 | 1.04e+00 | 0.1125 |
83939 | EIF2A | P76T-E | Human | Esophagus | ESCC | 1.06e-48 | 1.07e+00 | 0.1207 |
83939 | EIF2A | P79T-E | Human | Esophagus | ESCC | 1.25e-44 | 1.08e+00 | 0.1154 |
83939 | EIF2A | P80T-E | Human | Esophagus | ESCC | 3.37e-53 | 2.00e+00 | 0.155 |
83939 | EIF2A | P82T-E | Human | Esophagus | ESCC | 1.13e-14 | 1.23e+00 | 0.1072 |
83939 | EIF2A | P83T-E | Human | Esophagus | ESCC | 4.97e-63 | 2.24e+00 | 0.1738 |
83939 | EIF2A | P84T-E | Human | Esophagus | ESCC | 1.91e-06 | 8.36e-01 | 0.0933 |
83939 | EIF2A | P89T-E | Human | Esophagus | ESCC | 5.74e-24 | 2.01e+00 | 0.1752 |
83939 | EIF2A | P91T-E | Human | Esophagus | ESCC | 1.18e-16 | 2.07e+00 | 0.1828 |
83939 | EIF2A | P94T-E | Human | Esophagus | ESCC | 8.57e-03 | 8.49e-01 | 0.0879 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030099 | Colorectum | AD | myeloid cell differentiation | 119/3918 | 381/18723 | 1.24e-06 | 4.01e-05 | 119 |
GO:0006417 | Colorectum | AD | regulation of translation | 141/3918 | 468/18723 | 1.32e-06 | 4.22e-05 | 141 |
GO:0055076 | Colorectum | AD | transition metal ion homeostasis | 53/3918 | 138/18723 | 1.89e-06 | 5.65e-05 | 53 |
GO:0031667 | Colorectum | AD | response to nutrient levels | 138/3918 | 474/18723 | 1.22e-05 | 2.68e-04 | 138 |
GO:0006413 | Colorectum | AD | translational initiation | 45/3918 | 118/18723 | 1.35e-05 | 2.92e-04 | 45 |
GO:0046777 | Colorectum | AD | protein autophosphorylation | 74/3918 | 227/18723 | 2.48e-05 | 4.76e-04 | 74 |
GO:0042594 | Colorectum | AD | response to starvation | 63/3918 | 197/18723 | 1.77e-04 | 2.38e-03 | 63 |
GO:0055072 | Colorectum | AD | iron ion homeostasis | 32/3918 | 85/18723 | 2.97e-04 | 3.60e-03 | 32 |
GO:0006446 | Colorectum | AD | regulation of translational initiation | 28/3918 | 79/18723 | 2.02e-03 | 1.63e-02 | 28 |
GO:0002573 | Colorectum | AD | myeloid leukocyte differentiation | 60/3918 | 208/18723 | 4.03e-03 | 2.81e-02 | 60 |
GO:00064172 | Colorectum | MSS | regulation of translation | 134/3467 | 468/18723 | 4.43e-08 | 2.38e-06 | 134 |
GO:00300992 | Colorectum | MSS | myeloid cell differentiation | 110/3467 | 381/18723 | 4.48e-07 | 1.75e-05 | 110 |
GO:00064132 | Colorectum | MSS | translational initiation | 43/3467 | 118/18723 | 3.19e-06 | 9.38e-05 | 43 |
GO:00316672 | Colorectum | MSS | response to nutrient levels | 125/3467 | 474/18723 | 1.24e-05 | 2.88e-04 | 125 |
GO:00550762 | Colorectum | MSS | transition metal ion homeostasis | 45/3467 | 138/18723 | 4.99e-05 | 9.02e-04 | 45 |
GO:00467772 | Colorectum | MSS | protein autophosphorylation | 63/3467 | 227/18723 | 3.96e-04 | 4.91e-03 | 63 |
GO:00425942 | Colorectum | MSS | response to starvation | 56/3467 | 197/18723 | 4.25e-04 | 5.21e-03 | 56 |
GO:00550722 | Colorectum | MSS | iron ion homeostasis | 29/3467 | 85/18723 | 4.44e-04 | 5.32e-03 | 29 |
GO:00025731 | Colorectum | MSS | myeloid leukocyte differentiation | 57/3467 | 208/18723 | 1.01e-03 | 1.01e-02 | 57 |
GO:00064461 | Colorectum | MSS | regulation of translational initiation | 26/3467 | 79/18723 | 1.56e-03 | 1.42e-02 | 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF2A | SNV | Missense_Mutation | novel | c.1330A>C | p.Thr444Pro | p.T444P | Q9BY44 | protein_coding | tolerated(0.08) | benign(0.011) | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD |
EIF2A | SNV | Missense_Mutation | c.1669G>A | p.Gly557Arg | p.G557R | Q9BY44 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A0DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EIF2A | SNV | Missense_Mutation | novel | c.311N>T | p.Ala104Val | p.A104V | Q9BY44 | protein_coding | tolerated(0.2) | benign(0.017) | TCGA-EW-A6SC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | aromatase | SD |
EIF2A | SNV | Missense_Mutation | novel | c.923C>A | p.Pro308His | p.P308H | Q9BY44 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EIF2A | SNV | Missense_Mutation | novel | c.360N>C | p.Leu120Phe | p.L120F | Q9BY44 | protein_coding | deleterious(0.01) | benign(0.344) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
EIF2A | SNV | Missense_Mutation | c.580N>A | p.Ala194Thr | p.A194T | Q9BY44 | protein_coding | tolerated(0.06) | benign(0.131) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
EIF2A | SNV | Missense_Mutation | novel | c.701N>T | p.Ala234Val | p.A234V | Q9BY44 | protein_coding | deleterious(0.02) | probably_damaging(0.937) | TCGA-AA-3812-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
EIF2A | SNV | Missense_Mutation | c.869C>T | p.Ala290Val | p.A290V | Q9BY44 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
EIF2A | SNV | Missense_Mutation | rs769029119 | c.431N>A | p.Arg144His | p.R144H | Q9BY44 | protein_coding | deleterious(0.04) | benign(0.335) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EIF2A | SNV | Missense_Mutation | novel | c.506N>C | p.Lys169Thr | p.K169T | Q9BY44 | protein_coding | deleterious(0) | benign(0.358) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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