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Gene: EHBP1L1 |
Gene summary for EHBP1L1 |
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Gene information | Species | Human | Gene symbol | EHBP1L1 | Gene ID | 254102 |
Gene name | EH domain binding protein 1 like 1 | |
Gene Alias | EHBP1L1 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q8N3D4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
254102 | EHBP1L1 | P80T-E | Human | Esophagus | ESCC | 4.06e-04 | 1.22e-01 | 0.155 |
254102 | EHBP1L1 | P82T-E | Human | Esophagus | ESCC | 4.41e-11 | 4.38e-01 | 0.1072 |
254102 | EHBP1L1 | P83T-E | Human | Esophagus | ESCC | 2.40e-08 | 2.11e-01 | 0.1738 |
254102 | EHBP1L1 | P104T-E | Human | Esophagus | ESCC | 9.88e-07 | 4.22e-01 | 0.0931 |
254102 | EHBP1L1 | P107T-E | Human | Esophagus | ESCC | 1.08e-08 | 2.69e-01 | 0.171 |
254102 | EHBP1L1 | P127T-E | Human | Esophagus | ESCC | 3.07e-13 | 1.20e-01 | 0.0826 |
254102 | EHBP1L1 | P128T-E | Human | Esophagus | ESCC | 4.30e-10 | 5.27e-01 | 0.1241 |
254102 | EHBP1L1 | P130T-E | Human | Esophagus | ESCC | 2.83e-22 | 4.54e-01 | 0.1676 |
254102 | EHBP1L1 | HCC1_Meng | Human | Liver | HCC | 1.85e-19 | 8.49e-02 | 0.0246 |
254102 | EHBP1L1 | HCC2_Meng | Human | Liver | HCC | 6.26e-53 | 4.70e-01 | 0.0107 |
254102 | EHBP1L1 | HCC2 | Human | Liver | HCC | 1.12e-11 | 2.70e+00 | 0.5341 |
254102 | EHBP1L1 | HCC5 | Human | Liver | HCC | 3.14e-03 | 1.62e+00 | 0.4932 |
254102 | EHBP1L1 | Pt14.d | Human | Liver | HCC | 1.19e-02 | 2.14e-01 | 0.0143 |
254102 | EHBP1L1 | S014 | Human | Liver | HCC | 2.41e-05 | 3.38e-01 | 0.2254 |
254102 | EHBP1L1 | S015 | Human | Liver | HCC | 2.19e-04 | 3.30e-01 | 0.2375 |
254102 | EHBP1L1 | S016 | Human | Liver | HCC | 1.27e-06 | 2.90e-01 | 0.2243 |
254102 | EHBP1L1 | S027 | Human | Liver | HCC | 7.31e-07 | 6.33e-01 | 0.2446 |
254102 | EHBP1L1 | S028 | Human | Liver | HCC | 3.95e-26 | 7.92e-01 | 0.2503 |
254102 | EHBP1L1 | S029 | Human | Liver | HCC | 6.98e-16 | 7.12e-01 | 0.2581 |
254102 | EHBP1L1 | C21 | Human | Oral cavity | OSCC | 2.35e-25 | 8.11e-01 | 0.2678 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EHBP1L1 | SNV | Missense_Mutation | novel | c.352N>T | p.Val118Leu | p.V118L | Q8N3D4 | protein_coding | deleterious(0.02) | possibly_damaging(0.826) | TCGA-AC-A2QJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD |
EHBP1L1 | SNV | Missense_Mutation | novel | c.2887N>C | p.Glu963Gln | p.E963Q | Q8N3D4 | protein_coding | tolerated(0.1) | benign(0.184) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EHBP1L1 | SNV | Missense_Mutation | rs764167148 | c.149N>A | p.Arg50His | p.R50H | Q8N3D4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EHBP1L1 | SNV | Missense_Mutation | c.3395N>T | p.Thr1132Met | p.T1132M | Q8N3D4 | protein_coding | deleterious(0.01) | probably_damaging(0.944) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EHBP1L1 | SNV | Missense_Mutation | c.2087N>G | p.Ser696Cys | p.S696C | Q8N3D4 | protein_coding | deleterious(0.04) | possibly_damaging(0.533) | TCGA-E9-A1N5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
EHBP1L1 | insertion | Frame_Shift_Ins | novel | c.1206_1207insCCTGGAGTTCGCTTGTTAATTTATTTTCCTTCTT | p.Ala403ProfsTer15 | p.A403Pfs*15 | Q8N3D4 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
EHBP1L1 | SNV | Missense_Mutation | rs759333764 | c.148N>T | p.Arg50Cys | p.R50C | Q8N3D4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EHBP1L1 | SNV | Missense_Mutation | novel | c.4384N>T | p.His1462Tyr | p.H1462Y | Q8N3D4 | protein_coding | deleterious(0) | possibly_damaging(0.825) | TCGA-4J-AA1J-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
EHBP1L1 | SNV | Missense_Mutation | novel | c.494A>C | p.Asp165Ala | p.D165A | Q8N3D4 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
EHBP1L1 | SNV | Missense_Mutation | c.2546C>T | p.Ser849Leu | p.S849L | Q8N3D4 | protein_coding | deleterious(0.04) | benign(0.003) | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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