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Gene: EFNB1 |
Gene summary for EFNB1 |
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Gene information | Species | Human | Gene symbol | EFNB1 | Gene ID | 1947 |
Gene name | ephrin B1 | |
Gene Alias | CFND | |
Cytomap | Xq13.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | P98172 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1947 | EFNB1 | P20T-E | Human | Esophagus | ESCC | 3.59e-29 | 9.94e-01 | 0.1124 |
1947 | EFNB1 | P21T-E | Human | Esophagus | ESCC | 9.66e-36 | 9.19e-01 | 0.1617 |
1947 | EFNB1 | P22T-E | Human | Esophagus | ESCC | 6.28e-33 | 7.59e-01 | 0.1236 |
1947 | EFNB1 | P23T-E | Human | Esophagus | ESCC | 5.35e-15 | 6.74e-01 | 0.108 |
1947 | EFNB1 | P24T-E | Human | Esophagus | ESCC | 8.65e-13 | 5.16e-01 | 0.1287 |
1947 | EFNB1 | P26T-E | Human | Esophagus | ESCC | 2.42e-52 | 1.25e+00 | 0.1276 |
1947 | EFNB1 | P27T-E | Human | Esophagus | ESCC | 3.14e-44 | 1.10e+00 | 0.1055 |
1947 | EFNB1 | P28T-E | Human | Esophagus | ESCC | 4.94e-22 | 6.81e-01 | 0.1149 |
1947 | EFNB1 | P30T-E | Human | Esophagus | ESCC | 1.42e-13 | 8.55e-01 | 0.137 |
1947 | EFNB1 | P31T-E | Human | Esophagus | ESCC | 2.65e-62 | 1.31e+00 | 0.1251 |
1947 | EFNB1 | P32T-E | Human | Esophagus | ESCC | 3.41e-42 | 1.64e+00 | 0.1666 |
1947 | EFNB1 | P36T-E | Human | Esophagus | ESCC | 6.52e-26 | 1.14e+00 | 0.1187 |
1947 | EFNB1 | P37T-E | Human | Esophagus | ESCC | 4.65e-33 | 1.08e+00 | 0.1371 |
1947 | EFNB1 | P39T-E | Human | Esophagus | ESCC | 5.86e-10 | -3.34e-02 | 0.0894 |
1947 | EFNB1 | P40T-E | Human | Esophagus | ESCC | 2.37e-08 | 5.07e-01 | 0.109 |
1947 | EFNB1 | P42T-E | Human | Esophagus | ESCC | 1.82e-38 | 1.53e+00 | 0.1175 |
1947 | EFNB1 | P44T-E | Human | Esophagus | ESCC | 1.73e-06 | 3.86e-01 | 0.1096 |
1947 | EFNB1 | P47T-E | Human | Esophagus | ESCC | 5.99e-28 | 6.91e-01 | 0.1067 |
1947 | EFNB1 | P48T-E | Human | Esophagus | ESCC | 6.96e-12 | 4.08e-01 | 0.0959 |
1947 | EFNB1 | P49T-E | Human | Esophagus | ESCC | 7.76e-14 | 2.35e+00 | 0.1768 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0001667 | Colorectum | AD | ameboidal-type cell migration | 137/3918 | 475/18723 | 2.17e-05 | 4.33e-04 | 137 |
GO:0007409 | Colorectum | AD | axonogenesis | 122/3918 | 418/18723 | 3.36e-05 | 6.15e-04 | 122 |
GO:0061564 | Colorectum | AD | axon development | 132/3918 | 467/18723 | 8.40e-05 | 1.31e-03 | 132 |
GO:0045785 | Colorectum | AD | positive regulation of cell adhesion | 122/3918 | 437/18723 | 2.65e-04 | 3.28e-03 | 122 |
GO:0007411 | Colorectum | AD | axon guidance | 64/3918 | 227/18723 | 5.41e-03 | 3.55e-02 | 64 |
GO:0097485 | Colorectum | AD | neuron projection guidance | 64/3918 | 228/18723 | 6.02e-03 | 3.78e-02 | 64 |
GO:00016671 | Colorectum | SER | ameboidal-type cell migration | 105/2897 | 475/18723 | 6.97e-05 | 1.59e-03 | 105 |
GO:00457851 | Colorectum | SER | positive regulation of cell adhesion | 93/2897 | 437/18723 | 6.78e-04 | 9.04e-03 | 93 |
GO:00074111 | Colorectum | SER | axon guidance | 51/2897 | 227/18723 | 3.29e-03 | 2.82e-02 | 51 |
GO:00974851 | Colorectum | SER | neuron projection guidance | 51/2897 | 228/18723 | 3.61e-03 | 3.03e-02 | 51 |
GO:00615641 | Colorectum | SER | axon development | 94/2897 | 467/18723 | 3.78e-03 | 3.13e-02 | 94 |
GO:00074091 | Colorectum | SER | axonogenesis | 84/2897 | 418/18723 | 6.20e-03 | 4.49e-02 | 84 |
GO:00016672 | Colorectum | MSS | ameboidal-type cell migration | 120/3467 | 475/18723 | 1.37e-04 | 2.05e-03 | 120 |
GO:00457852 | Colorectum | MSS | positive regulation of cell adhesion | 110/3467 | 437/18723 | 2.94e-04 | 3.87e-03 | 110 |
GO:00074092 | Colorectum | MSS | axonogenesis | 105/3467 | 418/18723 | 4.32e-04 | 5.23e-03 | 105 |
GO:00615642 | Colorectum | MSS | axon development | 115/3467 | 467/18723 | 5.33e-04 | 6.00e-03 | 115 |
GO:0048762 | Colorectum | MSS | mesenchymal cell differentiation | 59/3467 | 236/18723 | 7.79e-03 | 4.84e-02 | 59 |
GO:0048013 | Colorectum | MSS | ephrin receptor signaling pathway | 17/3467 | 51/18723 | 8.28e-03 | 4.99e-02 | 17 |
GO:004578527 | Esophagus | ESCC | positive regulation of cell adhesion | 255/8552 | 437/18723 | 5.07e-08 | 9.11e-07 | 255 |
GO:00488638 | Esophagus | ESCC | stem cell differentiation | 122/8552 | 206/18723 | 5.95e-05 | 4.59e-04 | 122 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04360 | Colorectum | AD | Axon guidance | 61/2092 | 182/8465 | 4.36e-03 | 2.17e-02 | 1.38e-02 | 61 |
hsa043601 | Colorectum | AD | Axon guidance | 61/2092 | 182/8465 | 4.36e-03 | 2.17e-02 | 1.38e-02 | 61 |
hsa043602 | Colorectum | MSS | Axon guidance | 54/1875 | 182/8465 | 1.03e-02 | 3.69e-02 | 2.26e-02 | 54 |
hsa043603 | Colorectum | MSS | Axon guidance | 54/1875 | 182/8465 | 1.03e-02 | 3.69e-02 | 2.26e-02 | 54 |
hsa0436016 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
hsa0436017 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
hsa0436014 | Oral cavity | OSCC | Axon guidance | 97/3704 | 182/8465 | 5.59e-03 | 1.33e-02 | 6.76e-03 | 97 |
hsa0436015 | Oral cavity | OSCC | Axon guidance | 97/3704 | 182/8465 | 5.59e-03 | 1.33e-02 | 6.76e-03 | 97 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
EFNB1 | EPHB1 | EFNB1_EPHB1 | EPHB | Breast | Healthy |
EFNB1 | EPHA4 | EFNB1_EPHA4 | EPHB | Cervix | CC |
EFNB1 | EPHB2 | EFNB1_EPHB2 | EPHB | Cervix | CC |
EFNB1 | EPHA4 | EFNB1_EPHA4 | EPHB | CRC | AD |
EFNB1 | EPHB2 | EFNB1_EPHB2 | EPHB | CRC | AD |
EFNB1 | EPHB4 | EFNB1_EPHB4 | EPHB | CRC | AD |
EFNB1 | EPHA4 | EFNB1_EPHA4 | EPHB | CRC | ADJ |
EFNB1 | EPHB2 | EFNB1_EPHB2 | EPHB | CRC | ADJ |
EFNB1 | EPHA4 | EFNB1_EPHA4 | EPHB | CRC | MSI-H |
EFNB1 | EPHB2 | EFNB1_EPHB2 | EPHB | CRC | MSI-H |
EFNB1 | EPHB3 | EFNB1_EPHB3 | EPHB | CRC | MSI-H |
EFNB1 | EPHB4 | EFNB1_EPHB4 | EPHB | CRC | MSI-H |
EFNB1 | EPHB2 | EFNB1_EPHB2 | EPHB | CRC | MSS |
EFNB1 | EPHB3 | EFNB1_EPHB3 | EPHB | CRC | MSS |
EFNB1 | EPHB4 | EFNB1_EPHB4 | EPHB | CRC | MSS |
EFNB1 | EPHA4 | EFNB1_EPHA4 | EPHB | CRC | SER |
EFNB1 | EPHB2 | EFNB1_EPHB2 | EPHB | CRC | SER |
EFNB1 | EPHB3 | EFNB1_EPHB3 | EPHB | CRC | SER |
EFNB1 | EPHB4 | EFNB1_EPHB4 | EPHB | CRC | SER |
EFNB1 | EPHA4 | EFNB1_EPHA4 | EPHB | Endometrium | EEC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EFNB1 | SNV | Missense_Mutation | rs754504608 | c.796C>T | p.Arg266Cys | p.R266C | P98172 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A2-A04R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
EFNB1 | SNV | Missense_Mutation | novel | c.497N>G | p.Gln166Arg | p.Q166R | P98172 | protein_coding | deleterious(0.01) | possibly_damaging(0.726) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
EFNB1 | SNV | Missense_Mutation | rs367996552 | c.211N>T | p.Arg71Trp | p.R71W | P98172 | protein_coding | deleterious(0.01) | possibly_damaging(0.828) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
EFNB1 | SNV | Missense_Mutation | rs767055938 | c.212N>A | p.Arg71Gln | p.R71Q | P98172 | protein_coding | tolerated(0.46) | benign(0.024) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
EFNB1 | SNV | Missense_Mutation | c.575N>T | p.Ala192Val | p.A192V | P98172 | protein_coding | tolerated(0.42) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
EFNB1 | SNV | Missense_Mutation | novel | c.758N>A | p.Leu253His | p.L253H | P98172 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EFNB1 | SNV | Missense_Mutation | c.920N>A | p.Arg307Gln | p.R307Q | P98172 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AY-5543-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | oxaliplatin | SD | |
EFNB1 | insertion | In_Frame_Ins | novel | c.756_757insGTT | p.Leu252_Leu253insVal | p.L252_L253insV | P98172 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
EFNB1 | deletion | Frame_Shift_Del | c.872delG | p.Gly291AlafsTer30 | p.G291Afs*30 | P98172 | protein_coding | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
EFNB1 | deletion | Frame_Shift_Del | c.707_714delNNNNNNNN | p.Ser236CysfsTer80 | p.S236Cfs*80 | P98172 | protein_coding | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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