![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: DNAJC14 |
Gene summary for DNAJC14 |
![]() |
Gene information | Species | Human | Gene symbol | DNAJC14 | Gene ID | 85406 |
Gene name | DnaJ heat shock protein family (Hsp40) member C14 | |
Gene Alias | DNAJ | |
Cytomap | 12q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024RB64 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85406 | DNAJC14 | P75T-E | Human | Esophagus | ESCC | 2.40e-07 | 2.04e-01 | 0.1125 |
85406 | DNAJC14 | P76T-E | Human | Esophagus | ESCC | 6.78e-04 | 9.92e-02 | 0.1207 |
85406 | DNAJC14 | P79T-E | Human | Esophagus | ESCC | 3.64e-06 | 1.34e-01 | 0.1154 |
85406 | DNAJC14 | P80T-E | Human | Esophagus | ESCC | 3.36e-10 | 3.40e-01 | 0.155 |
85406 | DNAJC14 | P82T-E | Human | Esophagus | ESCC | 6.01e-03 | 1.76e-01 | 0.1072 |
85406 | DNAJC14 | P89T-E | Human | Esophagus | ESCC | 6.86e-11 | 4.26e-01 | 0.1752 |
85406 | DNAJC14 | P91T-E | Human | Esophagus | ESCC | 2.71e-06 | 5.03e-01 | 0.1828 |
85406 | DNAJC14 | P107T-E | Human | Esophagus | ESCC | 7.61e-04 | 1.47e-01 | 0.171 |
85406 | DNAJC14 | P127T-E | Human | Esophagus | ESCC | 4.40e-02 | 5.98e-02 | 0.0826 |
85406 | DNAJC14 | P128T-E | Human | Esophagus | ESCC | 2.31e-14 | 4.85e-01 | 0.1241 |
85406 | DNAJC14 | P130T-E | Human | Esophagus | ESCC | 1.61e-14 | 2.73e-01 | 0.1676 |
85406 | DNAJC14 | HCC1_Meng | Human | Liver | HCC | 1.40e-17 | 1.04e-02 | 0.0246 |
85406 | DNAJC14 | HCC2_Meng | Human | Liver | HCC | 1.84e-06 | 2.16e-02 | 0.0107 |
85406 | DNAJC14 | HCC1 | Human | Liver | HCC | 1.72e-09 | 3.16e+00 | 0.5336 |
85406 | DNAJC14 | HCC2 | Human | Liver | HCC | 1.20e-07 | 3.73e+00 | 0.5341 |
85406 | DNAJC14 | S014 | Human | Liver | HCC | 1.35e-11 | 3.39e-01 | 0.2254 |
85406 | DNAJC14 | S015 | Human | Liver | HCC | 5.15e-14 | 5.08e-01 | 0.2375 |
85406 | DNAJC14 | S016 | Human | Liver | HCC | 3.40e-13 | 4.23e-01 | 0.2243 |
85406 | DNAJC14 | S027 | Human | Liver | HCC | 4.02e-05 | 2.28e-01 | 0.2446 |
85406 | DNAJC14 | S028 | Human | Liver | HCC | 2.55e-09 | 3.47e-01 | 0.2503 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DNAJC14 | SNV | Missense_Mutation | novel | c.2030N>G | p.Ser677Cys | p.S677C | Q6Y2X3 | protein_coding | deleterious(0.01) | benign(0.371) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
DNAJC14 | SNV | Missense_Mutation | novel | c.623N>T | p.Arg208Leu | p.R208L | Q6Y2X3 | protein_coding | deleterious_low_confidence(0.01) | benign(0.195) | TCGA-A2-A0CR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
DNAJC14 | SNV | Missense_Mutation | c.262N>A | p.Glu88Lys | p.E88K | Q6Y2X3 | protein_coding | deleterious_low_confidence(0.02) | benign(0.003) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DNAJC14 | SNV | Missense_Mutation | c.446N>T | p.Ser149Phe | p.S149F | Q6Y2X3 | protein_coding | deleterious_low_confidence(0) | benign(0.332) | TCGA-BH-A0B0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
DNAJC14 | SNV | Missense_Mutation | novel | c.1310N>G | p.Val437Gly | p.V437G | Q6Y2X3 | protein_coding | deleterious(0) | possibly_damaging(0.767) | TCGA-E9-A243-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | PD |
DNAJC14 | SNV | Missense_Mutation | c.1510N>A | p.Glu504Lys | p.E504K | Q6Y2X3 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-GM-A2DI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
DNAJC14 | insertion | Frame_Shift_Ins | novel | c.1923_1924insATAAATGTATT | p.Asp642IlefsTer10 | p.D642Ifs*10 | Q6Y2X3 | protein_coding | TCGA-A8-A08O-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | PD | ||
DNAJC14 | deletion | Frame_Shift_Del | c.118_119delAG | p.Arg40GlyfsTer8 | p.R40Gfs*8 | Q6Y2X3 | protein_coding | TCGA-AC-A23C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | chemo | CR | |||
DNAJC14 | insertion | In_Frame_Ins | novel | c.564_565insAAATATGGACCTAGTATGGGAGGGTCAGGGAGTGCATGTAAGGAT | p.Ser188_Gly189insLysTyrGlyProSerMetGlyGlySerGlySerAlaCysLysAsp | p.S188_G189insKYGPSMGGSGSACKD | Q6Y2X3 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |||
DNAJC14 | SNV | Missense_Mutation | c.53N>T | p.Gly18Val | p.G18V | Q6Y2X3 | protein_coding | deleterious_low_confidence(0) | benign(0.172) | TCGA-C5-A1MF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |