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Gene: DNAJB14 |
Gene summary for DNAJB14 |
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Gene information | Species | Human | Gene symbol | DNAJB14 | Gene ID | 79982 |
Gene name | DnaJ heat shock protein family (Hsp40) member B14 | |
Gene Alias | EGNR9427 | |
Cytomap | 4q23 | |
Gene Type | protein-coding | GO ID | GO:0006457 | UniProtAcc | Q8TBM8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79982 | DNAJB14 | LZE22T | Human | Esophagus | ESCC | 1.31e-04 | 2.39e-01 | 0.068 |
79982 | DNAJB14 | LZE24T | Human | Esophagus | ESCC | 6.57e-20 | 3.99e-01 | 0.0596 |
79982 | DNAJB14 | LZE21T | Human | Esophagus | ESCC | 1.83e-06 | 4.12e-01 | 0.0655 |
79982 | DNAJB14 | LZE6T | Human | Esophagus | ESCC | 4.23e-06 | 2.72e-01 | 0.0845 |
79982 | DNAJB14 | P1T-E | Human | Esophagus | ESCC | 1.91e-07 | 4.73e-01 | 0.0875 |
79982 | DNAJB14 | P2T-E | Human | Esophagus | ESCC | 6.44e-43 | 6.50e-01 | 0.1177 |
79982 | DNAJB14 | P4T-E | Human | Esophagus | ESCC | 1.10e-31 | 7.23e-01 | 0.1323 |
79982 | DNAJB14 | P5T-E | Human | Esophagus | ESCC | 9.15e-18 | 3.12e-01 | 0.1327 |
79982 | DNAJB14 | P8T-E | Human | Esophagus | ESCC | 1.46e-24 | 3.46e-01 | 0.0889 |
79982 | DNAJB14 | P9T-E | Human | Esophagus | ESCC | 1.53e-12 | 2.05e-01 | 0.1131 |
79982 | DNAJB14 | P10T-E | Human | Esophagus | ESCC | 2.93e-25 | 4.23e-01 | 0.116 |
79982 | DNAJB14 | P11T-E | Human | Esophagus | ESCC | 7.37e-21 | 6.30e-01 | 0.1426 |
79982 | DNAJB14 | P12T-E | Human | Esophagus | ESCC | 9.52e-27 | 4.98e-01 | 0.1122 |
79982 | DNAJB14 | P15T-E | Human | Esophagus | ESCC | 8.06e-22 | 5.16e-01 | 0.1149 |
79982 | DNAJB14 | P16T-E | Human | Esophagus | ESCC | 1.09e-30 | 5.51e-01 | 0.1153 |
79982 | DNAJB14 | P17T-E | Human | Esophagus | ESCC | 1.09e-08 | 4.51e-01 | 0.1278 |
79982 | DNAJB14 | P19T-E | Human | Esophagus | ESCC | 2.42e-05 | 4.22e-01 | 0.1662 |
79982 | DNAJB14 | P20T-E | Human | Esophagus | ESCC | 1.94e-25 | 4.88e-01 | 0.1124 |
79982 | DNAJB14 | P21T-E | Human | Esophagus | ESCC | 9.61e-26 | 3.96e-01 | 0.1617 |
79982 | DNAJB14 | P22T-E | Human | Esophagus | ESCC | 6.27e-25 | 3.94e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
GO:0043161 | Colorectum | AD | proteasome-mediated ubiquitin-dependent protein catabolic process | 141/3918 | 412/18723 | 1.77e-10 | 1.68e-08 | 141 |
GO:0034976 | Colorectum | AD | response to endoplasmic reticulum stress | 90/3918 | 256/18723 | 8.48e-08 | 4.28e-06 | 90 |
GO:0006457 | Colorectum | AD | protein folding | 73/3918 | 212/18723 | 3.24e-06 | 9.10e-05 | 73 |
GO:0035966 | Colorectum | AD | response to topologically incorrect protein | 54/3918 | 159/18723 | 8.85e-05 | 1.36e-03 | 54 |
GO:0035967 | Colorectum | AD | cellular response to topologically incorrect protein | 42/3918 | 116/18723 | 1.04e-04 | 1.56e-03 | 42 |
GO:0006458 | Colorectum | AD | 'de novo' protein folding | 20/3918 | 43/18723 | 1.53e-04 | 2.16e-03 | 20 |
GO:0051084 | Colorectum | AD | 'de novo' posttranslational protein folding | 18/3918 | 39/18723 | 3.66e-04 | 4.24e-03 | 18 |
GO:0061077 | Colorectum | AD | chaperone-mediated protein folding | 26/3918 | 67/18723 | 6.20e-04 | 6.48e-03 | 26 |
GO:0051085 | Colorectum | AD | chaperone cofactor-dependent protein refolding | 15/3918 | 34/18723 | 1.96e-03 | 1.58e-02 | 15 |
GO:0036503 | Colorectum | AD | ERAD pathway | 34/3918 | 107/18723 | 5.57e-03 | 3.63e-02 | 34 |
GO:00104982 | Colorectum | MSS | proteasomal protein catabolic process | 157/3467 | 490/18723 | 2.39e-13 | 5.25e-11 | 157 |
GO:00431612 | Colorectum | MSS | proteasome-mediated ubiquitin-dependent protein catabolic process | 127/3467 | 412/18723 | 7.70e-10 | 6.32e-08 | 127 |
GO:00064572 | Colorectum | MSS | protein folding | 71/3467 | 212/18723 | 1.25e-07 | 5.91e-06 | 71 |
GO:00349762 | Colorectum | MSS | response to endoplasmic reticulum stress | 81/3467 | 256/18723 | 2.65e-07 | 1.10e-05 | 81 |
GO:00359672 | Colorectum | MSS | cellular response to topologically incorrect protein | 42/3467 | 116/18723 | 4.99e-06 | 1.38e-04 | 42 |
GO:00359662 | Colorectum | MSS | response to topologically incorrect protein | 53/3467 | 159/18723 | 5.50e-06 | 1.49e-04 | 53 |
GO:00064582 | Colorectum | MSS | 'de novo' protein folding | 20/3467 | 43/18723 | 2.50e-05 | 5.21e-04 | 20 |
GO:00510842 | Colorectum | MSS | 'de novo' posttranslational protein folding | 18/3467 | 39/18723 | 7.19e-05 | 1.21e-03 | 18 |
GO:00610772 | Colorectum | MSS | chaperone-mediated protein folding | 26/3467 | 67/18723 | 8.06e-05 | 1.33e-03 | 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DNAJB14 | SNV | Missense_Mutation | novel | c.19N>A | p.Glu7Lys | p.E7K | Q8TBM8 | protein_coding | deleterious(0) | possibly_damaging(0.519) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
DNAJB14 | SNV | Missense_Mutation | c.125N>T | p.Ser42Leu | p.S42L | Q8TBM8 | protein_coding | deleterious(0.02) | benign(0) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
DNAJB14 | SNV | Missense_Mutation | novel | c.599A>G | p.Asp200Gly | p.D200G | Q8TBM8 | protein_coding | deleterious(0) | possibly_damaging(0.54) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DNAJB14 | SNV | Missense_Mutation | c.380N>T | p.Ala127Val | p.A127V | Q8TBM8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-FU-A3HY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
DNAJB14 | SNV | Missense_Mutation | novel | c.364N>A | p.Glu122Lys | p.E122K | Q8TBM8 | protein_coding | deleterious(0.01) | benign(0.141) | TCGA-VS-A94X-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
DNAJB14 | SNV | Missense_Mutation | novel | c.400N>G | p.Lys134Glu | p.K134E | Q8TBM8 | protein_coding | deleterious(0) | possibly_damaging(0.656) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
DNAJB14 | SNV | Missense_Mutation | novel | c.569N>C | p.Arg190Thr | p.R190T | Q8TBM8 | protein_coding | deleterious(0.02) | benign(0.053) | TCGA-ZJ-A8QR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
DNAJB14 | SNV | Missense_Mutation | novel | c.173N>A | p.Gly58Glu | p.G58E | Q8TBM8 | protein_coding | tolerated(0.16) | benign(0.031) | TCGA-ZJ-AAXU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
DNAJB14 | SNV | Missense_Mutation | c.1123N>A | p.Leu375Ile | p.L375I | Q8TBM8 | protein_coding | tolerated(0.41) | benign(0.003) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
DNAJB14 | SNV | Missense_Mutation | c.667G>T | p.Ala223Ser | p.A223S | Q8TBM8 | protein_coding | tolerated(0.61) | benign(0.001) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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