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Gene: DMTF1 |
Gene summary for DMTF1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | DMTF1 | Gene ID | 9988 |
Gene name | cyclin D binding myb like transcription factor 1 | |
Gene Alias | DMP1 | |
Cytomap | 7q21.12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B3KMJ8 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9988 | DMTF1 | P57T-E | Human | Esophagus | ESCC | 3.86e-10 | 1.55e-01 | 0.0926 |
9988 | DMTF1 | P61T-E | Human | Esophagus | ESCC | 3.44e-16 | 2.19e-01 | 0.099 |
9988 | DMTF1 | P62T-E | Human | Esophagus | ESCC | 1.26e-21 | 3.82e-01 | 0.1302 |
9988 | DMTF1 | P65T-E | Human | Esophagus | ESCC | 3.11e-22 | 2.45e-01 | 0.0978 |
9988 | DMTF1 | P74T-E | Human | Esophagus | ESCC | 1.04e-14 | 4.22e-01 | 0.1479 |
9988 | DMTF1 | P75T-E | Human | Esophagus | ESCC | 4.41e-15 | 2.40e-01 | 0.1125 |
9988 | DMTF1 | P76T-E | Human | Esophagus | ESCC | 4.59e-08 | 9.65e-02 | 0.1207 |
9988 | DMTF1 | P79T-E | Human | Esophagus | ESCC | 3.51e-22 | 2.72e-01 | 0.1154 |
9988 | DMTF1 | P80T-E | Human | Esophagus | ESCC | 9.55e-18 | 2.86e-01 | 0.155 |
9988 | DMTF1 | P82T-E | Human | Esophagus | ESCC | 7.89e-09 | 2.89e-01 | 0.1072 |
9988 | DMTF1 | P83T-E | Human | Esophagus | ESCC | 5.25e-26 | 6.69e-01 | 0.1738 |
9988 | DMTF1 | P84T-E | Human | Esophagus | ESCC | 2.22e-03 | 1.30e-01 | 0.0933 |
9988 | DMTF1 | P89T-E | Human | Esophagus | ESCC | 1.39e-14 | 5.98e-01 | 0.1752 |
9988 | DMTF1 | P91T-E | Human | Esophagus | ESCC | 8.98e-06 | 6.39e-01 | 0.1828 |
9988 | DMTF1 | P107T-E | Human | Esophagus | ESCC | 1.37e-12 | 1.65e-01 | 0.171 |
9988 | DMTF1 | P126T-E | Human | Esophagus | ESCC | 1.23e-06 | 3.21e-01 | 0.1125 |
9988 | DMTF1 | P127T-E | Human | Esophagus | ESCC | 1.27e-14 | 2.43e-01 | 0.0826 |
9988 | DMTF1 | P128T-E | Human | Esophagus | ESCC | 3.18e-11 | 3.66e-01 | 0.1241 |
9988 | DMTF1 | P130T-E | Human | Esophagus | ESCC | 5.62e-26 | 5.16e-01 | 0.1676 |
9988 | DMTF1 | RNA-P17T-P17T-2 | Human | Lung | IAC | 1.25e-05 | 8.98e-01 | 0.3371 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DMTF1 | SNV | Missense_Mutation | rs767321632 | c.1856N>G | p.Pro619Arg | p.P619R | Q9Y222 | protein_coding | deleterious_low_confidence(0.02) | benign(0.015) | TCGA-BH-A8FZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DMTF1 | insertion | Nonsense_Mutation | novel | c.60_61insCTTTGCATGTTCTAGATCTGAATCCCTTGTTGGTTTTAGATG | p.Leu21_Thr22insCysMetPheTerIleTerIleProCysTrpPheTerMetLeu | p.L21_T22insCMF*I*IPCWF*ML | Q9Y222 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
DMTF1 | insertion | Frame_Shift_Ins | novel | c.1530_1531insCCTCTTTTTCT | p.Tyr511ProfsTer17 | p.Y511Pfs*17 | Q9Y222 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
DMTF1 | insertion | Nonsense_Mutation | novel | c.1490_1491insGCTTTGAGGGAATTTTCTGTAGATTTTCTTTTTAGC | p.Leu497_Pro498insLeuTerGlyAsnPheLeuTerIlePhePheLeuAla | p.L497_P498insL*GNFL*IFFLA | Q9Y222 | protein_coding | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | ||
DMTF1 | deletion | Frame_Shift_Del | novel | c.2253delN | p.Asp752MetfsTer6 | p.D752Mfs*6 | Q9Y222 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
DMTF1 | SNV | Missense_Mutation | rs149748596 | c.1774G>A | p.Asp592Asn | p.D592N | Q9Y222 | protein_coding | tolerated_low_confidence(0.18) | possibly_damaging(0.548) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DMTF1 | SNV | Missense_Mutation | novel | c.1706N>A | p.Arg569Lys | p.R569K | Q9Y222 | protein_coding | tolerated(0.26) | benign(0.001) | TCGA-VS-A94Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
DMTF1 | SNV | Missense_Mutation | c.794G>A | p.Arg265Gln | p.R265Q | Q9Y222 | protein_coding | deleterious(0.02) | probably_damaging(0.914) | TCGA-AA-3655-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DMTF1 | SNV | Missense_Mutation | c.1481N>A | p.Phe494Tyr | p.F494Y | Q9Y222 | protein_coding | tolerated(0.14) | benign(0.112) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
DMTF1 | SNV | Missense_Mutation | rs559006713 | c.508C>T | p.Arg170Cys | p.R170C | Q9Y222 | protein_coding | deleterious(0.01) | possibly_damaging(0.844) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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