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Gene: DHX38 |
Gene summary for DHX38 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | DHX38 | Gene ID | 9785 |
| Gene name | DEAH-box helicase 38 | |
| Gene Alias | DDX38 | |
| Cytomap | 16q22.2 | |
| Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | Q92620 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 9785 | DHX38 | P62T-E | Human | Esophagus | ESCC | 2.82e-29 | 6.35e-01 | 0.1302 |
| 9785 | DHX38 | P65T-E | Human | Esophagus | ESCC | 2.65e-07 | 1.97e-01 | 0.0978 |
| 9785 | DHX38 | P74T-E | Human | Esophagus | ESCC | 1.17e-15 | 3.46e-01 | 0.1479 |
| 9785 | DHX38 | P75T-E | Human | Esophagus | ESCC | 1.10e-20 | 4.13e-01 | 0.1125 |
| 9785 | DHX38 | P76T-E | Human | Esophagus | ESCC | 1.39e-14 | 2.18e-01 | 0.1207 |
| 9785 | DHX38 | P79T-E | Human | Esophagus | ESCC | 2.68e-15 | 2.45e-01 | 0.1154 |
| 9785 | DHX38 | P80T-E | Human | Esophagus | ESCC | 6.02e-05 | 2.81e-01 | 0.155 |
| 9785 | DHX38 | P82T-E | Human | Esophagus | ESCC | 3.07e-07 | 3.57e-01 | 0.1072 |
| 9785 | DHX38 | P83T-E | Human | Esophagus | ESCC | 3.41e-22 | 5.87e-01 | 0.1738 |
| 9785 | DHX38 | P84T-E | Human | Esophagus | ESCC | 4.54e-02 | 1.19e-01 | 0.0933 |
| 9785 | DHX38 | P89T-E | Human | Esophagus | ESCC | 1.10e-06 | 5.24e-01 | 0.1752 |
| 9785 | DHX38 | P91T-E | Human | Esophagus | ESCC | 1.89e-10 | 1.02e+00 | 0.1828 |
| 9785 | DHX38 | P104T-E | Human | Esophagus | ESCC | 2.41e-02 | 3.40e-01 | 0.0931 |
| 9785 | DHX38 | P107T-E | Human | Esophagus | ESCC | 7.60e-18 | 4.64e-01 | 0.171 |
| 9785 | DHX38 | P126T-E | Human | Esophagus | ESCC | 8.00e-04 | 6.26e-01 | 0.1125 |
| 9785 | DHX38 | P127T-E | Human | Esophagus | ESCC | 5.08e-10 | 3.04e-01 | 0.0826 |
| 9785 | DHX38 | P128T-E | Human | Esophagus | ESCC | 1.28e-02 | 3.22e-01 | 0.1241 |
| 9785 | DHX38 | P130T-E | Human | Esophagus | ESCC | 3.49e-32 | 6.77e-01 | 0.1676 |
| 9785 | DHX38 | HCC1_Meng | Human | Liver | HCC | 1.34e-18 | 9.87e-03 | 0.0246 |
| 9785 | DHX38 | HCC2_Meng | Human | Liver | HCC | 1.51e-08 | 6.19e-02 | 0.0107 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
| GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
| GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
| GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
| GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
| GO:000037522 | Liver | HCC | RNA splicing, via transesterification reactions | 228/7958 | 324/18723 | 1.47e-24 | 4.06e-22 | 228 |
| GO:000037722 | Liver | HCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
| GO:000039822 | Liver | HCC | mRNA splicing, via spliceosome | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
| GO:000838020 | Oral cavity | OSCC | RNA splicing | 308/7305 | 434/18723 | 2.43e-42 | 7.70e-39 | 308 |
| GO:000037519 | Oral cavity | OSCC | RNA splicing, via transesterification reactions | 225/7305 | 324/18723 | 5.20e-29 | 2.99e-26 | 225 |
| GO:000037719 | Oral cavity | OSCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 221/7305 | 320/18723 | 5.50e-28 | 2.18e-25 | 221 |
| GO:000039819 | Oral cavity | OSCC | mRNA splicing, via spliceosome | 221/7305 | 320/18723 | 5.50e-28 | 2.18e-25 | 221 |
| GO:0008380110 | Oral cavity | LP | RNA splicing | 237/4623 | 434/18723 | 1.82e-41 | 3.79e-38 | 237 |
| GO:0000375110 | Oral cavity | LP | RNA splicing, via transesterification reactions | 181/4623 | 324/18723 | 1.36e-33 | 1.70e-30 | 181 |
| GO:0000377110 | Oral cavity | LP | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 179/4623 | 320/18723 | 2.48e-33 | 2.22e-30 | 179 |
| GO:0000398110 | Oral cavity | LP | mRNA splicing, via spliceosome | 179/4623 | 320/18723 | 2.48e-33 | 2.22e-30 | 179 |
| GO:0008380113 | Thyroid | PTC | RNA splicing | 273/5968 | 434/18723 | 4.44e-41 | 1.40e-37 | 273 |
| GO:0000375113 | Thyroid | PTC | RNA splicing, via transesterification reactions | 202/5968 | 324/18723 | 6.81e-30 | 3.91e-27 | 202 |
| GO:0000377113 | Thyroid | PTC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 199/5968 | 320/18723 | 2.96e-29 | 1.44e-26 | 199 |
| GO:0000398113 | Thyroid | PTC | mRNA splicing, via spliceosome | 199/5968 | 320/18723 | 2.96e-29 | 1.44e-26 | 199 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
| hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
| hsa0304022 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
| hsa0304032 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
| hsa0304016 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
| hsa0304017 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
| hsa0304026 | Oral cavity | LP | Spliceosome | 106/2418 | 217/8465 | 1.30e-10 | 2.40e-09 | 1.55e-09 | 106 |
| hsa0304036 | Oral cavity | LP | Spliceosome | 106/2418 | 217/8465 | 1.30e-10 | 2.40e-09 | 1.55e-09 | 106 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| DHX38 | SNV | Missense_Mutation | c.2715N>A | p.Asp905Glu | p.D905E | Q92620 | protein_coding | deleterious(0.01) | possibly_damaging(0.867) | TCGA-A8-A0A9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | |
| DHX38 | SNV | Missense_Mutation | novel | c.121N>T | p.Ala41Ser | p.A41S | Q92620 | protein_coding | tolerated(0.24) | benign(0.023) | TCGA-AC-A2QI-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR |
| DHX38 | SNV | Missense_Mutation | rs372776663 | c.133N>T | p.Arg45Cys | p.R45C | Q92620 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
| DHX38 | SNV | Missense_Mutation | c.731G>A | p.Arg244Gln | p.R244Q | Q92620 | protein_coding | tolerated(0.3) | benign(0.007) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| DHX38 | SNV | Missense_Mutation | c.952G>A | p.Asp318Asn | p.D318N | Q92620 | protein_coding | tolerated(0.1) | benign(0.142) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
| DHX38 | SNV | Missense_Mutation | novel | c.673T>C | p.Ser225Pro | p.S225P | Q92620 | protein_coding | tolerated(0.21) | benign(0.003) | TCGA-E2-A1LA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
| DHX38 | insertion | Frame_Shift_Ins | novel | c.1718_1719insGGTGCCCTTGGTCTCCCATGTTTACCCAGGAGCTCTTTTTC | p.Tyr574ValfsTer20 | p.Y574Vfs*20 | Q92620 | protein_coding | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
| DHX38 | insertion | In_Frame_Ins | novel | c.3008_3009insGAGGCGGCCCCGGGAGCC | p.Val1003_Pro1004insArgArgProArgGluPro | p.V1003_P1004insRRPREP | Q92620 | protein_coding | TCGA-A2-A0EV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| DHX38 | insertion | Frame_Shift_Ins | novel | c.3043_3044insGGTGCTGCTGCTCAAGTCCCTCGGGGTGCAGG | p.Tyr1015TrpfsTer54 | p.Y1015Wfs*54 | Q92620 | protein_coding | TCGA-A8-A09B-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD | ||
| DHX38 | deletion | Frame_Shift_Del | rs767582321 | c.2822_2829delNNNNNNNN | p.Thr942AlafsTer20 | p.T942Afs*20 | Q92620 | protein_coding | TCGA-AC-A3EH-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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