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Gene: CXorf56 |
Gene summary for CXORF56 |
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Gene information | Species | Human | Gene symbol | CXorf56 | Gene ID | 63932 |
Gene name | STING1 ER exit protein 1 | |
Gene Alias | CXorf56 | |
Cytomap | Xq24 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9H5V9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
63932 | CXorf56 | P80T-E | Human | Esophagus | ESCC | 2.55e-13 | 3.81e-01 | 0.155 |
63932 | CXorf56 | P83T-E | Human | Esophagus | ESCC | 8.33e-22 | 5.88e-01 | 0.1738 |
63932 | CXorf56 | P84T-E | Human | Esophagus | ESCC | 6.97e-03 | 2.02e-01 | 0.0933 |
63932 | CXorf56 | P89T-E | Human | Esophagus | ESCC | 3.98e-03 | 3.50e-01 | 0.1752 |
63932 | CXorf56 | P91T-E | Human | Esophagus | ESCC | 5.06e-07 | 4.49e-01 | 0.1828 |
63932 | CXorf56 | P107T-E | Human | Esophagus | ESCC | 5.09e-13 | 2.78e-01 | 0.171 |
63932 | CXorf56 | P127T-E | Human | Esophagus | ESCC | 4.83e-11 | 1.83e-01 | 0.0826 |
63932 | CXorf56 | P128T-E | Human | Esophagus | ESCC | 1.78e-11 | 3.17e-01 | 0.1241 |
63932 | CXorf56 | P130T-E | Human | Esophagus | ESCC | 4.76e-13 | 2.88e-01 | 0.1676 |
63932 | CXorf56 | S43 | Human | Liver | Cirrhotic | 4.06e-02 | -7.00e-02 | -0.0187 |
63932 | CXorf56 | HCC1_Meng | Human | Liver | HCC | 3.53e-04 | -2.96e-02 | 0.0246 |
63932 | CXorf56 | HCC2_Meng | Human | Liver | HCC | 1.71e-09 | 7.34e-02 | 0.0107 |
63932 | CXorf56 | HCC1 | Human | Liver | HCC | 1.19e-06 | 3.05e+00 | 0.5336 |
63932 | CXorf56 | HCC2 | Human | Liver | HCC | 3.61e-14 | 2.72e+00 | 0.5341 |
63932 | CXorf56 | HCC5 | Human | Liver | HCC | 3.31e-10 | 1.23e+00 | 0.4932 |
63932 | CXorf56 | S016 | Human | Liver | HCC | 6.11e-04 | 1.30e-01 | 0.2243 |
63932 | CXorf56 | S028 | Human | Liver | HCC | 2.91e-08 | 3.50e-01 | 0.2503 |
63932 | CXorf56 | S029 | Human | Liver | HCC | 3.69e-04 | 2.63e-01 | 0.2581 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CXorf56 | SNV | Missense_Mutation | c.200A>C | p.Lys67Thr | p.K67T | Q9H5V9 | protein_coding | deleterious(0) | possibly_damaging(0.732) | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
CXorf56 | SNV | Missense_Mutation | novel | c.454G>A | p.Glu152Lys | p.E152K | Q9H5V9 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-C5-A902-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
CXorf56 | SNV | Missense_Mutation | novel | c.445N>A | p.Asp149Asn | p.D149N | Q9H5V9 | protein_coding | deleterious(0.01) | possibly_damaging(0.841) | TCGA-AA-3819-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CXorf56 | SNV | Missense_Mutation | novel | c.112N>C | p.Val38Leu | p.V38L | Q9H5V9 | protein_coding | tolerated(0.05) | benign(0.255) | TCGA-AA-3831-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CXorf56 | SNV | Missense_Mutation | c.287C>T | p.Pro96Leu | p.P96L | Q9H5V9 | protein_coding | tolerated(0.11) | benign(0.029) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
CXorf56 | SNV | Missense_Mutation | novel | c.79C>A | p.Leu27Ile | p.L27I | Q9H5V9 | protein_coding | deleterious(0.01) | probably_damaging(0.981) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CXorf56 | SNV | Missense_Mutation | rs764134233 | c.587N>T | p.Ala196Val | p.A196V | Q9H5V9 | protein_coding | tolerated(0.18) | benign(0.281) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
CXorf56 | SNV | Missense_Mutation | c.227N>A | p.Thr76Asn | p.T76N | Q9H5V9 | protein_coding | tolerated(0.1) | benign(0.003) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
CXorf56 | SNV | Missense_Mutation | novel | c.13N>A | p.Val5Met | p.V5M | Q9H5V9 | protein_coding | deleterious(0.01) | probably_damaging(0.984) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
CXorf56 | SNV | Missense_Mutation | novel | c.540N>T | p.Met180Ile | p.M180I | Q9H5V9 | protein_coding | tolerated(0.2) | benign(0.005) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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