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Gene: CTSZ |
Gene summary for CTSZ |
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Gene information | Species | Human | Gene symbol | CTSZ | Gene ID | 1522 |
Gene name | cathepsin Z | |
Gene Alias | CTSX | |
Cytomap | 20q13.32 | |
Gene Type | protein-coding | GO ID | GO:0001763 | UniProtAcc | Q9UBR2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1522 | CTSZ | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.63e-04 | 2.92e-01 | 0.0171 |
1522 | CTSZ | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.25e-02 | 1.16e-01 | 0.0338 |
1522 | CTSZ | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.83e-02 | 2.19e-01 | 0.0674 |
1522 | CTSZ | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.92e-05 | 2.04e-01 | 0.0588 |
1522 | CTSZ | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.04e-08 | 1.27e-01 | 0.281 |
1522 | CTSZ | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.45e-25 | 9.06e-01 | 0.3859 |
1522 | CTSZ | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.04e-06 | 5.19e-01 | 0.2585 |
1522 | CTSZ | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.09e-13 | 5.41e-01 | 0.3005 |
1522 | CTSZ | LZE2T | Human | Esophagus | ESCC | 2.88e-02 | 5.06e-01 | 0.082 |
1522 | CTSZ | LZE4T | Human | Esophagus | ESCC | 4.86e-14 | 3.55e-01 | 0.0811 |
1522 | CTSZ | LZE5T | Human | Esophagus | ESCC | 2.89e-04 | 1.50e-01 | 0.0514 |
1522 | CTSZ | LZE7T | Human | Esophagus | ESCC | 1.26e-02 | 2.16e-01 | 0.0667 |
1522 | CTSZ | LZE22T | Human | Esophagus | ESCC | 2.08e-02 | 3.64e-01 | 0.068 |
1522 | CTSZ | LZE24T | Human | Esophagus | ESCC | 3.46e-14 | 2.02e-01 | 0.0596 |
1522 | CTSZ | P1T-E | Human | Esophagus | ESCC | 1.06e-11 | 2.80e-01 | 0.0875 |
1522 | CTSZ | P2T-E | Human | Esophagus | ESCC | 8.18e-16 | 4.36e-01 | 0.1177 |
1522 | CTSZ | P4T-E | Human | Esophagus | ESCC | 5.65e-28 | 5.56e-01 | 0.1323 |
1522 | CTSZ | P5T-E | Human | Esophagus | ESCC | 1.22e-14 | 4.26e-01 | 0.1327 |
1522 | CTSZ | P8T-E | Human | Esophagus | ESCC | 9.50e-20 | 4.25e-01 | 0.0889 |
1522 | CTSZ | P9T-E | Human | Esophagus | ESCC | 9.49e-20 | 4.55e-01 | 0.1131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00458619 | Breast | Precancer | negative regulation of proteolysis | 50/1080 | 351/18723 | 2.99e-09 | 2.39e-07 | 50 |
GO:00709979 | Breast | Precancer | neuron death | 50/1080 | 361/18723 | 7.75e-09 | 5.70e-07 | 50 |
GO:00514029 | Breast | Precancer | neuron apoptotic process | 38/1080 | 246/18723 | 2.68e-08 | 1.75e-06 | 38 |
GO:19012149 | Breast | Precancer | regulation of neuron death | 41/1080 | 319/18723 | 1.27e-06 | 4.80e-05 | 41 |
GO:00435237 | Breast | Precancer | regulation of neuron apoptotic process | 31/1080 | 212/18723 | 1.69e-06 | 6.08e-05 | 31 |
GO:00510989 | Breast | Precancer | regulation of binding | 44/1080 | 363/18723 | 2.59e-06 | 8.65e-05 | 44 |
GO:19012169 | Breast | Precancer | positive regulation of neuron death | 16/1080 | 97/18723 | 1.29e-04 | 2.24e-03 | 16 |
GO:00435258 | Breast | Precancer | positive regulation of neuron apoptotic process | 11/1080 | 58/18723 | 4.17e-04 | 5.56e-03 | 11 |
GO:00316393 | Breast | Precancer | plasminogen activation | 6/1080 | 24/18723 | 1.99e-03 | 1.90e-02 | 6 |
GO:00511008 | Breast | Precancer | negative regulation of binding | 19/1080 | 162/18723 | 2.56e-03 | 2.32e-02 | 19 |
GO:00605625 | Breast | Precancer | epithelial tube morphogenesis | 31/1080 | 325/18723 | 4.21e-03 | 3.31e-02 | 31 |
GO:00516047 | Breast | Precancer | protein maturation | 28/1080 | 294/18723 | 6.45e-03 | 4.50e-02 | 28 |
GO:004586114 | Breast | IDC | negative regulation of proteolysis | 70/1434 | 351/18723 | 8.21e-14 | 2.22e-11 | 70 |
GO:007099714 | Breast | IDC | neuron death | 57/1434 | 361/18723 | 1.31e-07 | 7.38e-06 | 57 |
GO:005109814 | Breast | IDC | regulation of binding | 57/1434 | 363/18723 | 1.59e-07 | 8.76e-06 | 57 |
GO:005140213 | Breast | IDC | neuron apoptotic process | 42/1434 | 246/18723 | 7.21e-07 | 3.35e-05 | 42 |
GO:190121414 | Breast | IDC | regulation of neuron death | 48/1434 | 319/18723 | 5.01e-06 | 1.69e-04 | 48 |
GO:004352313 | Breast | IDC | regulation of neuron apoptotic process | 35/1434 | 212/18723 | 1.26e-05 | 3.29e-04 | 35 |
GO:190121614 | Breast | IDC | positive regulation of neuron death | 19/1434 | 97/18723 | 1.22e-04 | 2.25e-03 | 19 |
GO:006056212 | Breast | IDC | epithelial tube morphogenesis | 44/1434 | 325/18723 | 1.58e-04 | 2.73e-03 | 44 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa042108 | Breast | Precancer | Apoptosis | 25/684 | 136/8465 | 7.61e-05 | 6.87e-04 | 5.26e-04 | 25 |
hsa0421013 | Breast | Precancer | Apoptosis | 25/684 | 136/8465 | 7.61e-05 | 6.87e-04 | 5.26e-04 | 25 |
hsa0421022 | Breast | IDC | Apoptosis | 31/867 | 136/8465 | 1.34e-05 | 1.61e-04 | 1.20e-04 | 31 |
hsa0421032 | Breast | IDC | Apoptosis | 31/867 | 136/8465 | 1.34e-05 | 1.61e-04 | 1.20e-04 | 31 |
hsa0421041 | Breast | DCIS | Apoptosis | 29/846 | 136/8465 | 5.92e-05 | 5.97e-04 | 4.40e-04 | 29 |
hsa0421051 | Breast | DCIS | Apoptosis | 29/846 | 136/8465 | 5.92e-05 | 5.97e-04 | 4.40e-04 | 29 |
hsa042109 | Cervix | CC | Apoptosis | 36/1267 | 136/8465 | 3.21e-04 | 1.68e-03 | 9.91e-04 | 36 |
hsa0421014 | Cervix | CC | Apoptosis | 36/1267 | 136/8465 | 3.21e-04 | 1.68e-03 | 9.91e-04 | 36 |
hsa0421042 | Cervix | N_HPV | Apoptosis | 14/349 | 136/8465 | 1.40e-03 | 9.06e-03 | 7.08e-03 | 14 |
hsa0421052 | Cervix | N_HPV | Apoptosis | 14/349 | 136/8465 | 1.40e-03 | 9.06e-03 | 7.08e-03 | 14 |
hsa04142 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa041421 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa04210 | Colorectum | MSS | Apoptosis | 44/1875 | 136/8465 | 3.66e-03 | 1.66e-02 | 1.01e-02 | 44 |
hsa042101 | Colorectum | MSS | Apoptosis | 44/1875 | 136/8465 | 3.66e-03 | 1.66e-02 | 1.01e-02 | 44 |
hsa0414222 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0421027 | Esophagus | ESCC | Apoptosis | 102/4205 | 136/8465 | 1.05e-09 | 1.21e-08 | 6.21e-09 | 102 |
hsa0414232 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0421037 | Esophagus | ESCC | Apoptosis | 102/4205 | 136/8465 | 1.05e-09 | 1.21e-08 | 6.21e-09 | 102 |
hsa041424 | Liver | Cirrhotic | Lysosome | 68/2530 | 132/8465 | 1.34e-07 | 1.97e-06 | 1.21e-06 | 68 |
hsa042106 | Liver | Cirrhotic | Apoptosis | 58/2530 | 136/8465 | 9.84e-04 | 5.55e-03 | 3.42e-03 | 58 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CTSZ | SNV | Missense_Mutation | c.731C>T | p.Ser244Phe | p.S244F | Q9UBR2 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
CTSZ | SNV | Missense_Mutation | c.867C>G | p.Asn289Lys | p.N289K | Q9UBR2 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EW-A1OZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | trastuzumab | SD | |
CTSZ | SNV | Missense_Mutation | c.785N>T | p.Ser262Leu | p.S262L | Q9UBR2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A1MP-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
CTSZ | SNV | Missense_Mutation | novel | c.668N>G | p.Ala223Gly | p.A223G | Q9UBR2 | protein_coding | tolerated(0.06) | benign(0.001) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CTSZ | SNV | Missense_Mutation | rs748740856 | c.418N>A | p.Val140Met | p.V140M | Q9UBR2 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
CTSZ | SNV | Missense_Mutation | rs201081854 | c.335N>T | p.Ala112Val | p.A112V | Q9UBR2 | protein_coding | tolerated(0.12) | benign(0.015) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CTSZ | SNV | Missense_Mutation | novel | c.718N>C | p.Asn240His | p.N240H | Q9UBR2 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CTSZ | SNV | Missense_Mutation | rs201081854 | c.335N>T | p.Ala112Val | p.A112V | Q9UBR2 | protein_coding | tolerated(0.12) | benign(0.015) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |
CTSZ | SNV | Missense_Mutation | rs202127342 | c.580N>A | p.Gly194Ser | p.G194S | Q9UBR2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CTSZ | SNV | Missense_Mutation | rs368797360 | c.880N>A | p.Glu294Lys | p.E294K | Q9UBR2 | protein_coding | tolerated(0.53) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1522 | CTSZ | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 178103092 | ODANACATIB |
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