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Gene: CSNK2A1 |
Gene summary for CSNK2A1 |
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Gene information | Species | Human | Gene symbol | CSNK2A1 | Gene ID | 1457 |
Gene name | casein kinase 2 alpha 1 | |
Gene Alias | CK2A1 | |
Cytomap | 20p13 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | P68400 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1457 | CSNK2A1 | A001-C-014 | Human | Colorectum | FAP | 3.17e-18 | -3.66e-01 | 0.0135 |
1457 | CSNK2A1 | A002-C-016 | Human | Colorectum | FAP | 6.40e-18 | -3.89e-01 | 0.0521 |
1457 | CSNK2A1 | A015-C-002 | Human | Colorectum | FAP | 1.10e-09 | -3.93e-01 | -0.0763 |
1457 | CSNK2A1 | A001-C-203 | Human | Colorectum | FAP | 3.85e-11 | -2.57e-01 | -0.0481 |
1457 | CSNK2A1 | A002-C-116 | Human | Colorectum | FAP | 9.82e-29 | -4.09e-01 | -0.0452 |
1457 | CSNK2A1 | A014-C-008 | Human | Colorectum | FAP | 7.25e-11 | -4.35e-01 | -0.191 |
1457 | CSNK2A1 | A018-E-020 | Human | Colorectum | FAP | 5.34e-17 | -4.31e-01 | -0.2034 |
1457 | CSNK2A1 | F034 | Human | Colorectum | FAP | 1.63e-18 | -3.42e-01 | -0.0665 |
1457 | CSNK2A1 | F072B | Human | Colorectum | FAP | 1.87e-05 | -2.19e-01 | 0.257 |
1457 | CSNK2A1 | CRC-3-11773 | Human | Colorectum | CRC | 1.71e-14 | -4.16e-01 | 0.2564 |
1457 | CSNK2A1 | LZE2T | Human | Esophagus | ESCC | 8.55e-03 | 9.86e-01 | 0.082 |
1457 | CSNK2A1 | LZE4T | Human | Esophagus | ESCC | 1.57e-21 | 7.95e-01 | 0.0811 |
1457 | CSNK2A1 | LZE7T | Human | Esophagus | ESCC | 5.88e-07 | 7.60e-01 | 0.0667 |
1457 | CSNK2A1 | LZE8T | Human | Esophagus | ESCC | 1.16e-05 | 3.92e-01 | 0.067 |
1457 | CSNK2A1 | LZE20T | Human | Esophagus | ESCC | 2.98e-08 | 3.67e-01 | 0.0662 |
1457 | CSNK2A1 | LZE24T | Human | Esophagus | ESCC | 7.06e-18 | 7.18e-01 | 0.0596 |
1457 | CSNK2A1 | LZE21T | Human | Esophagus | ESCC | 1.04e-03 | 4.09e-01 | 0.0655 |
1457 | CSNK2A1 | LZE6T | Human | Esophagus | ESCC | 1.90e-03 | 4.86e-01 | 0.0845 |
1457 | CSNK2A1 | P1T-E | Human | Esophagus | ESCC | 1.65e-15 | 9.49e-01 | 0.0875 |
1457 | CSNK2A1 | P2T-E | Human | Esophagus | ESCC | 2.38e-53 | 1.09e+00 | 0.1177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:20012339 | Breast | Precancer | regulation of apoptotic signaling pathway | 65/1080 | 356/18723 | 7.70e-17 | 3.17e-14 | 65 |
GO:00525479 | Breast | Precancer | regulation of peptidase activity | 71/1080 | 461/18723 | 2.72e-14 | 6.94e-12 | 71 |
GO:00525489 | Breast | Precancer | regulation of endopeptidase activity | 67/1080 | 432/18723 | 1.06e-13 | 2.36e-11 | 67 |
GO:00064578 | Breast | Precancer | protein folding | 43/1080 | 212/18723 | 3.48e-13 | 7.45e-11 | 43 |
GO:20001169 | Breast | Precancer | regulation of cysteine-type endopeptidase activity | 43/1080 | 235/18723 | 1.30e-11 | 1.83e-09 | 43 |
GO:00432819 | Breast | Precancer | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 40/1080 | 209/18723 | 1.59e-11 | 2.07e-09 | 40 |
GO:20012349 | Breast | Precancer | negative regulation of apoptotic signaling pathway | 39/1080 | 224/18723 | 5.35e-10 | 4.77e-08 | 39 |
GO:00458619 | Breast | Precancer | negative regulation of proteolysis | 50/1080 | 351/18723 | 2.99e-09 | 2.39e-07 | 50 |
GO:00610778 | Breast | Precancer | chaperone-mediated protein folding | 19/1080 | 67/18723 | 4.22e-09 | 3.28e-07 | 19 |
GO:00513468 | Breast | Precancer | negative regulation of hydrolase activity | 50/1080 | 379/18723 | 3.85e-08 | 2.34e-06 | 50 |
GO:00104668 | Breast | Precancer | negative regulation of peptidase activity | 38/1080 | 262/18723 | 1.46e-07 | 7.82e-06 | 38 |
GO:00109519 | Breast | Precancer | negative regulation of endopeptidase activity | 37/1080 | 252/18723 | 1.55e-07 | 8.05e-06 | 37 |
GO:20001179 | Breast | Precancer | negative regulation of cysteine-type endopeptidase activity | 19/1080 | 86/18723 | 3.36e-07 | 1.58e-05 | 19 |
GO:19033629 | Breast | Precancer | regulation of cellular protein catabolic process | 36/1080 | 255/18723 | 6.03e-07 | 2.55e-05 | 36 |
GO:00421769 | Breast | Precancer | regulation of protein catabolic process | 47/1080 | 391/18723 | 1.50e-06 | 5.58e-05 | 47 |
GO:00431548 | Breast | Precancer | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 17/1080 | 78/18723 | 1.69e-06 | 6.08e-05 | 17 |
GO:19030509 | Breast | Precancer | regulation of proteolysis involved in cellular protein catabolic process | 31/1080 | 221/18723 | 4.10e-06 | 1.27e-04 | 31 |
GO:00313309 | Breast | Precancer | negative regulation of cellular catabolic process | 34/1080 | 262/18723 | 8.16e-06 | 2.20e-04 | 34 |
GO:19033638 | Breast | Precancer | negative regulation of cellular protein catabolic process | 14/1080 | 75/18723 | 8.54e-05 | 1.63e-03 | 14 |
GO:00098959 | Breast | Precancer | negative regulation of catabolic process | 36/1080 | 320/18723 | 9.92e-05 | 1.83e-03 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0413716 | Breast | Precancer | Mitophagy - animal | 15/684 | 72/8465 | 5.22e-04 | 3.93e-03 | 3.01e-03 | 15 |
hsa0452018 | Breast | Precancer | Adherens junction | 17/684 | 93/8465 | 1.11e-03 | 7.57e-03 | 5.80e-03 | 17 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0413717 | Breast | Precancer | Mitophagy - animal | 15/684 | 72/8465 | 5.22e-04 | 3.93e-03 | 3.01e-03 | 15 |
hsa0452019 | Breast | Precancer | Adherens junction | 17/684 | 93/8465 | 1.11e-03 | 7.57e-03 | 5.80e-03 | 17 |
hsa0502023 | Breast | IDC | Prion disease | 102/867 | 273/8465 | 3.70e-34 | 4.01e-32 | 3.00e-32 | 102 |
hsa0501023 | Breast | IDC | Alzheimer disease | 107/867 | 384/8465 | 1.70e-23 | 7.88e-22 | 5.90e-22 | 107 |
hsa0502223 | Breast | IDC | Pathways of neurodegeneration - multiple diseases | 116/867 | 476/8465 | 3.63e-20 | 1.18e-18 | 8.82e-19 | 116 |
hsa0413723 | Breast | IDC | Mitophagy - animal | 17/867 | 72/8465 | 7.61e-04 | 6.04e-03 | 4.52e-03 | 17 |
hsa0502033 | Breast | IDC | Prion disease | 102/867 | 273/8465 | 3.70e-34 | 4.01e-32 | 3.00e-32 | 102 |
hsa0501033 | Breast | IDC | Alzheimer disease | 107/867 | 384/8465 | 1.70e-23 | 7.88e-22 | 5.90e-22 | 107 |
hsa0502233 | Breast | IDC | Pathways of neurodegeneration - multiple diseases | 116/867 | 476/8465 | 3.63e-20 | 1.18e-18 | 8.82e-19 | 116 |
hsa0413733 | Breast | IDC | Mitophagy - animal | 17/867 | 72/8465 | 7.61e-04 | 6.04e-03 | 4.52e-03 | 17 |
hsa0502043 | Breast | DCIS | Prion disease | 100/846 | 273/8465 | 1.44e-33 | 1.55e-31 | 1.14e-31 | 100 |
hsa0501043 | Breast | DCIS | Alzheimer disease | 105/846 | 384/8465 | 3.23e-23 | 1.49e-21 | 1.10e-21 | 105 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CSNK2A1 | SNV | Missense_Mutation | rs61730061 | c.398T>C | p.Ile133Thr | p.I133T | P68400 | protein_coding | deleterious(0.02) | probably_damaging(0.937) | TCGA-AN-A0XP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CSNK2A1 | SNV | Missense_Mutation | c.228N>T | p.Lys76Asn | p.K76N | P68400 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-BH-A0W7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
CSNK2A1 | SNV | Missense_Mutation | c.785N>G | p.Asn262Ser | p.N262S | P68400 | protein_coding | tolerated(0.13) | benign(0.006) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CSNK2A1 | SNV | Missense_Mutation | novel | c.134N>C | p.Leu45Ser | p.L45S | P68400 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CSNK2A1 | SNV | Missense_Mutation | c.989N>T | p.Asp330Val | p.D330V | P68400 | protein_coding | deleterious(0.01) | benign(0.001) | TCGA-AA-3489-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CSNK2A1 | SNV | Missense_Mutation | c.1154N>A | p.Ala385Asp | p.A385D | P68400 | protein_coding | deleterious_low_confidence(0) | benign(0.056) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CSNK2A1 | SNV | Missense_Mutation | c.811N>T | p.Asp271Tyr | p.D271Y | P68400 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CSNK2A1 | SNV | Missense_Mutation | c.420T>G | p.Ile140Met | p.I140M | P68400 | protein_coding | deleterious(0) | possibly_damaging(0.787) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CSNK2A1 | SNV | Missense_Mutation | c.833G>A | p.Arg278Gln | p.R278Q | P68400 | protein_coding | deleterious(0) | possibly_damaging(0.874) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CSNK2A1 | SNV | Missense_Mutation | c.848N>A | p.Arg283His | p.R283H | P68400 | protein_coding | tolerated(0.06) | possibly_damaging(0.877) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1457 | CSNK2A1 | KINASE, TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASE, TUMOR SUPPRESSOR | inhibitor | 249565806 | SILMITASERTIB | |
1457 | CSNK2A1 | KINASE, TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASE, TUMOR SUPPRESSOR | CX-4945 | SILMITASERTIB | ||
1457 | CSNK2A1 | KINASE, TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASE, TUMOR SUPPRESSOR | TAMATINIB | R-406 | ||
1457 | CSNK2A1 | KINASE, TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASE, TUMOR SUPPRESSOR | inhibitor | 249565820 | ||
1457 | CSNK2A1 | KINASE, TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASE, TUMOR SUPPRESSOR | AZAKENPAULLONE | AZAKENPAULLONE | ||
1457 | CSNK2A1 | KINASE, TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASE, TUMOR SUPPRESSOR | HEPARIN | HEPARIN | 7794926 | |
1457 | CSNK2A1 | KINASE, TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASE, TUMOR SUPPRESSOR | inhibitor | HESPERADIN | HESPERADIN | 19035792 |
1457 | CSNK2A1 | KINASE, TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASE, TUMOR SUPPRESSOR | MLN-8054 | MLN-8054 | ||
1457 | CSNK2A1 | KINASE, TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASE, TUMOR SUPPRESSOR | SP-600125 | SP-600125 | ||
1457 | CSNK2A1 | KINASE, TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASE, TUMOR SUPPRESSOR | CYC-116 | CYC-116 |
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