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Gene: CRYBG3 |
Gene summary for CRYBG3 |
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Gene information | Species | Human | Gene symbol | CRYBG3 | Gene ID | 131544 |
Gene name | crystallin beta-gamma domain containing 3 | |
Gene Alias | DKFZp667G2110 | |
Cytomap | 3q11.2 | |
Gene Type | protein-coding | GO ID | GO:0001654 | UniProtAcc | Q68DQ2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
131544 | CRYBG3 | P61T-E | Human | Esophagus | ESCC | 1.52e-14 | 3.71e-01 | 0.099 |
131544 | CRYBG3 | P62T-E | Human | Esophagus | ESCC | 1.34e-36 | 7.33e-01 | 0.1302 |
131544 | CRYBG3 | P65T-E | Human | Esophagus | ESCC | 1.70e-12 | 2.10e-01 | 0.0978 |
131544 | CRYBG3 | P74T-E | Human | Esophagus | ESCC | 3.85e-12 | 3.68e-01 | 0.1479 |
131544 | CRYBG3 | P75T-E | Human | Esophagus | ESCC | 4.19e-17 | 3.28e-01 | 0.1125 |
131544 | CRYBG3 | P76T-E | Human | Esophagus | ESCC | 9.70e-11 | 1.58e-01 | 0.1207 |
131544 | CRYBG3 | P79T-E | Human | Esophagus | ESCC | 1.43e-18 | 3.68e-01 | 0.1154 |
131544 | CRYBG3 | P80T-E | Human | Esophagus | ESCC | 5.65e-15 | 5.51e-01 | 0.155 |
131544 | CRYBG3 | P82T-E | Human | Esophagus | ESCC | 1.97e-07 | 4.89e-01 | 0.1072 |
131544 | CRYBG3 | P83T-E | Human | Esophagus | ESCC | 4.80e-12 | 2.39e-01 | 0.1738 |
131544 | CRYBG3 | P91T-E | Human | Esophagus | ESCC | 1.50e-04 | 6.89e-01 | 0.1828 |
131544 | CRYBG3 | P104T-E | Human | Esophagus | ESCC | 1.98e-03 | 1.67e-01 | 0.0931 |
131544 | CRYBG3 | P107T-E | Human | Esophagus | ESCC | 5.17e-17 | 5.00e-01 | 0.171 |
131544 | CRYBG3 | P126T-E | Human | Esophagus | ESCC | 4.60e-06 | 6.25e-01 | 0.1125 |
131544 | CRYBG3 | P127T-E | Human | Esophagus | ESCC | 1.02e-15 | 3.30e-01 | 0.0826 |
131544 | CRYBG3 | P128T-E | Human | Esophagus | ESCC | 2.89e-24 | 6.26e-01 | 0.1241 |
131544 | CRYBG3 | P130T-E | Human | Esophagus | ESCC | 2.75e-14 | 2.85e-01 | 0.1676 |
131544 | CRYBG3 | HCC1_Meng | Human | Liver | HCC | 1.89e-11 | -1.81e-02 | 0.0246 |
131544 | CRYBG3 | HCC2_Meng | Human | Liver | HCC | 1.24e-11 | 1.25e-01 | 0.0107 |
131544 | CRYBG3 | HCC2 | Human | Liver | HCC | 1.20e-07 | 3.96e+00 | 0.5341 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CRYBG3 | SNV | Missense_Mutation | novel | c.1711G>A | p.Asp571Asn | p.D571N | Q68DQ2 | protein_coding | tolerated(0.11) | benign(0.085) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
CRYBG3 | SNV | Missense_Mutation | c.7111C>A | p.Gln2371Lys | p.Q2371K | Q68DQ2 | protein_coding | tolerated(0.1) | benign(0.291) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CRYBG3 | SNV | Missense_Mutation | rs746125280 | c.7034N>A | p.Arg2345Gln | p.R2345Q | Q68DQ2 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CRYBG3 | SNV | Missense_Mutation | c.6529N>A | p.Asp2177Asn | p.D2177N | Q68DQ2 | protein_coding | tolerated(0.05) | possibly_damaging(0.664) | TCGA-AR-A250-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
CRYBG3 | SNV | Missense_Mutation | c.6995N>C | p.Val2332Ala | p.V2332A | Q68DQ2 | protein_coding | deleterious(0) | possibly_damaging(0.887) | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CRYBG3 | SNV | Missense_Mutation | rs766412063 | c.8465N>A | p.Ser2822Asn | p.S2822N | Q68DQ2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
CRYBG3 | SNV | Missense_Mutation | c.6079N>A | p.His2027Asn | p.H2027N | Q68DQ2 | protein_coding | deleterious(0.02) | benign(0) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CRYBG3 | SNV | Missense_Mutation | c.7598N>G | p.His2533Arg | p.H2533R | Q68DQ2 | protein_coding | tolerated(0.31) | benign(0.345) | TCGA-E2-A14W-01 | Breast | breast invasive carcinoma | Male | >=65 | I/II | Chemotherapy | cytoxan | SD | |
CRYBG3 | SNV | Missense_Mutation | rs753391188 | c.7687N>T | p.Arg2563Trp | p.R2563W | Q68DQ2 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-E2-A155-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
CRYBG3 | SNV | Missense_Mutation | c.7360N>C | p.Glu2454Gln | p.E2454Q | Q68DQ2 | protein_coding | deleterious(0.01) | probably_damaging(0.974) | TCGA-E2-A15M-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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