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Gene: CRY1 |
Gene summary for CRY1 |
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Gene information | Species | Human | Gene symbol | CRY1 | Gene ID | 1407 |
Gene name | cryptochrome circadian regulator 1 | |
Gene Alias | DSPD | |
Cytomap | 12q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000075 | UniProtAcc | A2I2P0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1407 | CRY1 | P28T-E | Human | Esophagus | ESCC | 5.02e-20 | 3.61e-01 | 0.1149 |
1407 | CRY1 | P30T-E | Human | Esophagus | ESCC | 1.95e-23 | 6.51e-01 | 0.137 |
1407 | CRY1 | P31T-E | Human | Esophagus | ESCC | 1.49e-08 | 9.79e-02 | 0.1251 |
1407 | CRY1 | P32T-E | Human | Esophagus | ESCC | 5.80e-16 | 1.01e-01 | 0.1666 |
1407 | CRY1 | P36T-E | Human | Esophagus | ESCC | 1.38e-22 | 5.48e-01 | 0.1187 |
1407 | CRY1 | P37T-E | Human | Esophagus | ESCC | 7.55e-09 | 2.03e-01 | 0.1371 |
1407 | CRY1 | P39T-E | Human | Esophagus | ESCC | 7.73e-13 | 2.77e-01 | 0.0894 |
1407 | CRY1 | P40T-E | Human | Esophagus | ESCC | 5.57e-08 | 1.76e-01 | 0.109 |
1407 | CRY1 | P42T-E | Human | Esophagus | ESCC | 1.20e-16 | 2.44e-01 | 0.1175 |
1407 | CRY1 | P44T-E | Human | Esophagus | ESCC | 1.45e-10 | 2.06e-01 | 0.1096 |
1407 | CRY1 | P47T-E | Human | Esophagus | ESCC | 1.43e-06 | 1.47e-01 | 0.1067 |
1407 | CRY1 | P48T-E | Human | Esophagus | ESCC | 4.04e-22 | 3.02e-01 | 0.0959 |
1407 | CRY1 | P49T-E | Human | Esophagus | ESCC | 6.75e-17 | 9.25e-01 | 0.1768 |
1407 | CRY1 | P52T-E | Human | Esophagus | ESCC | 6.83e-17 | 2.76e-01 | 0.1555 |
1407 | CRY1 | P54T-E | Human | Esophagus | ESCC | 3.70e-30 | 5.62e-01 | 0.0975 |
1407 | CRY1 | P56T-E | Human | Esophagus | ESCC | 1.32e-02 | 4.53e-01 | 0.1613 |
1407 | CRY1 | P57T-E | Human | Esophagus | ESCC | 2.11e-18 | 4.64e-01 | 0.0926 |
1407 | CRY1 | P61T-E | Human | Esophagus | ESCC | 1.70e-21 | 4.33e-01 | 0.099 |
1407 | CRY1 | P62T-E | Human | Esophagus | ESCC | 1.70e-37 | 6.19e-01 | 0.1302 |
1407 | CRY1 | P65T-E | Human | Esophagus | ESCC | 2.45e-20 | 3.30e-01 | 0.0978 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190332016 | Endometrium | AEH | regulation of protein modification by small protein conjugation or removal | 67/2100 | 242/18723 | 1.10e-12 | 2.26e-10 | 67 |
GO:003139616 | Endometrium | AEH | regulation of protein ubiquitination | 57/2100 | 210/18723 | 1.24e-10 | 1.40e-08 | 57 |
GO:004854516 | Endometrium | AEH | response to steroid hormone | 76/2100 | 339/18723 | 2.15e-09 | 1.77e-07 | 76 |
GO:00485119 | Endometrium | AEH | rhythmic process | 67/2100 | 298/18723 | 1.69e-08 | 1.04e-06 | 67 |
GO:003139716 | Endometrium | AEH | negative regulation of protein ubiquitination | 28/2100 | 83/18723 | 4.36e-08 | 2.40e-06 | 28 |
GO:003052210 | Endometrium | AEH | intracellular receptor signaling pathway | 60/2100 | 265/18723 | 7.16e-08 | 3.77e-06 | 60 |
GO:190332116 | Endometrium | AEH | negative regulation of protein modification by small protein conjugation or removal | 30/2100 | 95/18723 | 7.94e-08 | 4.04e-06 | 30 |
GO:004259310 | Endometrium | AEH | glucose homeostasis | 55/2100 | 258/18723 | 1.87e-06 | 5.74e-05 | 55 |
GO:003350010 | Endometrium | AEH | carbohydrate homeostasis | 55/2100 | 259/18723 | 2.12e-06 | 6.31e-05 | 55 |
GO:00076239 | Endometrium | AEH | circadian rhythm | 47/2100 | 210/18723 | 2.54e-06 | 7.28e-05 | 47 |
GO:00329227 | Endometrium | AEH | circadian regulation of gene expression | 22/2100 | 68/18723 | 2.65e-06 | 7.57e-05 | 22 |
GO:007138310 | Endometrium | AEH | cellular response to steroid hormone stimulus | 44/2100 | 204/18723 | 1.41e-05 | 3.01e-04 | 44 |
GO:005123510 | Endometrium | AEH | maintenance of location | 60/2100 | 327/18723 | 8.19e-05 | 1.22e-03 | 60 |
GO:19033225 | Endometrium | AEH | positive regulation of protein modification by small protein conjugation or removal | 31/2100 | 138/18723 | 1.14e-04 | 1.61e-03 | 31 |
GO:00510515 | Endometrium | AEH | negative regulation of transport | 79/2100 | 470/18723 | 1.51e-04 | 1.99e-03 | 79 |
GO:00305189 | Endometrium | AEH | intracellular steroid hormone receptor signaling pathway | 27/2100 | 116/18723 | 1.65e-04 | 2.15e-03 | 27 |
GO:00313984 | Endometrium | AEH | positive regulation of protein ubiquitination | 27/2100 | 119/18723 | 2.57e-04 | 3.04e-03 | 27 |
GO:004343410 | Endometrium | AEH | response to peptide hormone | 70/2100 | 414/18723 | 2.93e-04 | 3.35e-03 | 70 |
GO:00434019 | Endometrium | AEH | steroid hormone mediated signaling pathway | 29/2100 | 136/18723 | 4.71e-04 | 4.91e-03 | 29 |
GO:00097558 | Endometrium | AEH | hormone-mediated signaling pathway | 37/2100 | 190/18723 | 5.64e-04 | 5.62e-03 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa047105 | Esophagus | ESCC | Circadian rhythm | 24/4205 | 34/8465 | 1.09e-02 | 2.51e-02 | 1.29e-02 | 24 |
hsa0471012 | Esophagus | ESCC | Circadian rhythm | 24/4205 | 34/8465 | 1.09e-02 | 2.51e-02 | 1.29e-02 | 24 |
hsa04710 | Lung | IAC | Circadian rhythm | 10/1053 | 34/8465 | 6.70e-03 | 2.76e-02 | 1.83e-02 | 10 |
hsa047101 | Lung | IAC | Circadian rhythm | 10/1053 | 34/8465 | 6.70e-03 | 2.76e-02 | 1.83e-02 | 10 |
hsa047102 | Lung | AIS | Circadian rhythm | 11/961 | 34/8465 | 9.22e-04 | 7.11e-03 | 4.55e-03 | 11 |
hsa047103 | Lung | AIS | Circadian rhythm | 11/961 | 34/8465 | 9.22e-04 | 7.11e-03 | 4.55e-03 | 11 |
hsa047104 | Prostate | BPH | Circadian rhythm | 15/1718 | 34/8465 | 1.40e-03 | 5.85e-03 | 3.62e-03 | 15 |
hsa0471011 | Prostate | BPH | Circadian rhythm | 15/1718 | 34/8465 | 1.40e-03 | 5.85e-03 | 3.62e-03 | 15 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CRY1 | SNV | Missense_Mutation | c.1344N>T | p.Trp448Cys | p.W448C | Q16526 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | |
CRY1 | insertion | Frame_Shift_Ins | novel | c.197_198insCATGGAAATGCCCA | p.Arg67MetfsTer8 | p.R67Mfs*8 | Q16526 | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | ||
CRY1 | insertion | Frame_Shift_Ins | novel | c.195_196insACAACTAG | p.Leu66ThrfsTer7 | p.L66Tfs*7 | Q16526 | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | ||
CRY1 | SNV | Missense_Mutation | c.1452G>A | p.Met484Ile | p.M484I | Q16526 | protein_coding | tolerated(0.05) | possibly_damaging(0.49) | TCGA-EK-A2H0-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
CRY1 | SNV | Missense_Mutation | rs149558160 | c.767N>A | p.Arg256Gln | p.R256Q | Q16526 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-MA-AA3X-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
CRY1 | SNV | Missense_Mutation | c.1452G>A | p.Met484Ile | p.M484I | Q16526 | protein_coding | tolerated(0.05) | possibly_damaging(0.49) | TCGA-ZJ-A8QQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
CRY1 | SNV | Missense_Mutation | rs770965692 | c.1249G>A | p.Gly417Ser | p.G417S | Q16526 | protein_coding | tolerated(0.13) | benign(0.001) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CRY1 | SNV | Missense_Mutation | rs749506981 | c.1042C>T | p.Arg348Cys | p.R348C | Q16526 | protein_coding | deleterious(0) | possibly_damaging(0.606) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CRY1 | SNV | Missense_Mutation | c.722C>T | p.Ala241Val | p.A241V | Q16526 | protein_coding | deleterious(0.03) | benign(0.42) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CRY1 | SNV | Missense_Mutation | novel | c.380N>T | p.Arg127Ile | p.R127I | Q16526 | protein_coding | deleterious(0.03) | benign(0.158) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1407 | CRY1 | NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR | 252166810 | |||
1407 | CRY1 | NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR | lithium | LITHIUM |
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