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Gene: COQ7 |
Gene summary for COQ7 |
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Gene information | Species | Human | Gene symbol | COQ7 | Gene ID | 10229 |
Gene name | coenzyme Q7, hydroxylase | |
Gene Alias | CAT5 | |
Cytomap | 16p12.3 | |
Gene Type | protein-coding | GO ID | GO:0006743 | UniProtAcc | Q99807 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10229 | COQ7 | P61T-E | Human | Esophagus | ESCC | 1.44e-14 | 3.08e-01 | 0.099 |
10229 | COQ7 | P62T-E | Human | Esophagus | ESCC | 7.31e-41 | 6.99e-01 | 0.1302 |
10229 | COQ7 | P65T-E | Human | Esophagus | ESCC | 1.41e-07 | 8.64e-02 | 0.0978 |
10229 | COQ7 | P74T-E | Human | Esophagus | ESCC | 2.24e-11 | 2.08e-01 | 0.1479 |
10229 | COQ7 | P75T-E | Human | Esophagus | ESCC | 8.97e-27 | 4.31e-01 | 0.1125 |
10229 | COQ7 | P76T-E | Human | Esophagus | ESCC | 1.67e-26 | 4.26e-01 | 0.1207 |
10229 | COQ7 | P79T-E | Human | Esophagus | ESCC | 9.20e-22 | 4.63e-01 | 0.1154 |
10229 | COQ7 | P80T-E | Human | Esophagus | ESCC | 1.78e-17 | 3.88e-01 | 0.155 |
10229 | COQ7 | P82T-E | Human | Esophagus | ESCC | 3.07e-02 | 2.32e-01 | 0.1072 |
10229 | COQ7 | P83T-E | Human | Esophagus | ESCC | 5.74e-24 | 6.04e-01 | 0.1738 |
10229 | COQ7 | P89T-E | Human | Esophagus | ESCC | 1.20e-14 | 5.95e-01 | 0.1752 |
10229 | COQ7 | P91T-E | Human | Esophagus | ESCC | 3.90e-11 | 6.67e-01 | 0.1828 |
10229 | COQ7 | P107T-E | Human | Esophagus | ESCC | 1.19e-21 | 4.10e-01 | 0.171 |
10229 | COQ7 | P126T-E | Human | Esophagus | ESCC | 1.46e-06 | 4.58e-01 | 0.1125 |
10229 | COQ7 | P127T-E | Human | Esophagus | ESCC | 2.19e-19 | 3.57e-01 | 0.0826 |
10229 | COQ7 | P128T-E | Human | Esophagus | ESCC | 2.03e-16 | 4.01e-01 | 0.1241 |
10229 | COQ7 | P130T-E | Human | Esophagus | ESCC | 4.68e-08 | 2.46e-01 | 0.1676 |
10229 | COQ7 | C04 | Human | Oral cavity | OSCC | 3.76e-02 | 3.91e-01 | 0.2633 |
10229 | COQ7 | C21 | Human | Oral cavity | OSCC | 2.69e-17 | 6.27e-01 | 0.2678 |
10229 | COQ7 | C30 | Human | Oral cavity | OSCC | 1.17e-19 | 9.20e-01 | 0.3055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000756820 | Esophagus | ESCC | aging | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:190166112 | Esophagus | ESCC | quinone metabolic process | 34/8552 | 40/18723 | 3.00e-07 | 4.27e-06 | 34 |
GO:200037718 | Esophagus | ESCC | regulation of reactive oxygen species metabolic process | 100/8552 | 157/18723 | 3.87e-06 | 4.17e-05 | 100 |
GO:00067432 | Esophagus | ESCC | ubiquinone metabolic process | 17/8552 | 19/18723 | 9.02e-05 | 6.50e-04 | 17 |
GO:007259318 | Esophagus | ESCC | reactive oxygen species metabolic process | 137/8552 | 239/18723 | 1.82e-04 | 1.16e-03 | 137 |
GO:00067442 | Esophagus | ESCC | ubiquinone biosynthetic process | 15/8552 | 17/18723 | 3.48e-04 | 2.03e-03 | 15 |
GO:19016632 | Esophagus | ESCC | quinone biosynthetic process | 15/8552 | 17/18723 | 3.48e-04 | 2.03e-03 | 15 |
GO:00421805 | Esophagus | ESCC | cellular ketone metabolic process | 120/8552 | 211/18723 | 6.70e-04 | 3.55e-03 | 120 |
GO:000756818 | Oral cavity | OSCC | aging | 194/7305 | 339/18723 | 6.18e-12 | 2.33e-10 | 194 |
GO:19016613 | Oral cavity | OSCC | quinone metabolic process | 32/7305 | 40/18723 | 1.40e-07 | 2.34e-06 | 32 |
GO:200037716 | Oral cavity | OSCC | regulation of reactive oxygen species metabolic process | 92/7305 | 157/18723 | 4.96e-07 | 7.27e-06 | 92 |
GO:00421804 | Oral cavity | OSCC | cellular ketone metabolic process | 111/7305 | 211/18723 | 3.94e-05 | 3.45e-04 | 111 |
GO:0006743 | Oral cavity | OSCC | ubiquinone metabolic process | 16/7305 | 19/18723 | 7.05e-05 | 5.60e-04 | 16 |
GO:007259316 | Oral cavity | OSCC | reactive oxygen species metabolic process | 122/7305 | 239/18723 | 9.73e-05 | 7.34e-04 | 122 |
GO:0006744 | Oral cavity | OSCC | ubiquinone biosynthetic process | 14/7305 | 17/18723 | 3.31e-04 | 2.04e-03 | 14 |
GO:1901663 | Oral cavity | OSCC | quinone biosynthetic process | 14/7305 | 17/18723 | 3.31e-04 | 2.04e-03 | 14 |
GO:0042181 | Oral cavity | OSCC | ketone biosynthetic process | 26/7305 | 43/18723 | 3.55e-03 | 1.49e-02 | 26 |
GO:000756819 | Oral cavity | LP | aging | 125/4623 | 339/18723 | 3.29e-07 | 9.62e-06 | 125 |
GO:200037717 | Oral cavity | LP | regulation of reactive oxygen species metabolic process | 67/4623 | 157/18723 | 5.54e-07 | 1.51e-05 | 67 |
GO:190166111 | Oral cavity | LP | quinone metabolic process | 24/4623 | 40/18723 | 2.17e-06 | 4.85e-05 | 24 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa012404 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa00130 | Oral cavity | OSCC | Ubiquinone and other terpenoid-quinone biosynthesis | 9/3704 | 11/8465 | 1.19e-02 | 2.62e-02 | 1.33e-02 | 9 |
hsa0124011 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa001301 | Oral cavity | OSCC | Ubiquinone and other terpenoid-quinone biosynthesis | 9/3704 | 11/8465 | 1.19e-02 | 2.62e-02 | 1.33e-02 | 9 |
hsa001302 | Oral cavity | LP | Ubiquinone and other terpenoid-quinone biosynthesis | 8/2418 | 11/8465 | 3.03e-03 | 1.29e-02 | 8.35e-03 | 8 |
hsa0124021 | Oral cavity | LP | Biosynthesis of cofactors | 57/2418 | 153/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 57 |
hsa001303 | Oral cavity | LP | Ubiquinone and other terpenoid-quinone biosynthesis | 8/2418 | 11/8465 | 3.03e-03 | 1.29e-02 | 8.35e-03 | 8 |
hsa0124031 | Oral cavity | LP | Biosynthesis of cofactors | 57/2418 | 153/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 57 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COQ7 | SNV | Missense_Mutation | rs188968280 | c.629N>T | p.Ala210Val | p.A210V | Q99807 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AR-A254-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
COQ7 | SNV | Missense_Mutation | c.647G>C | p.Arg216Thr | p.R216T | Q99807 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
COQ7 | SNV | Missense_Mutation | rs201474239 | c.592N>A | p.Val198Ile | p.V198I | Q99807 | protein_coding | tolerated(0.45) | benign(0.003) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
COQ7 | SNV | Missense_Mutation | rs373106255 | c.325A>C | p.Thr109Pro | p.T109P | Q99807 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
COQ7 | SNV | Missense_Mutation | rs753589660 | c.464C>T | p.Thr155Met | p.T155M | Q99807 | protein_coding | tolerated(0.1) | benign(0.017) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
COQ7 | SNV | Missense_Mutation | rs777014954 | c.419N>T | p.Ala140Val | p.A140V | Q99807 | protein_coding | deleterious(0) | possibly_damaging(0.54) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
COQ7 | SNV | Missense_Mutation | rs763957708 | c.379N>A | p.Ala127Thr | p.A127T | Q99807 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
COQ7 | SNV | Missense_Mutation | rs749629099 | c.523N>T | p.Arg175Trp | p.R175W | Q99807 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
COQ7 | SNV | Missense_Mutation | novel | c.590C>T | p.Ala197Val | p.A197V | Q99807 | protein_coding | tolerated(0.27) | benign(0.005) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
COQ7 | SNV | Missense_Mutation | rs201819287 | c.178N>A | p.Glu60Lys | p.E60K | Q99807 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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