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Gene: CLMN |
Gene summary for CLMN |
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Gene information | Species | Human | Gene symbol | CLMN | Gene ID | 79789 |
Gene name | calmin | |
Gene Alias | CLMN | |
Cytomap | 14q32.13 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q6NUQ2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79789 | CLMN | LZE22T | Human | Esophagus | ESCC | 6.52e-03 | 2.43e-01 | 0.068 |
79789 | CLMN | P2T-E | Human | Esophagus | ESCC | 1.15e-10 | 1.87e-01 | 0.1177 |
79789 | CLMN | P4T-E | Human | Esophagus | ESCC | 4.54e-05 | 1.70e-02 | 0.1323 |
79789 | CLMN | P5T-E | Human | Esophagus | ESCC | 2.86e-02 | 7.64e-03 | 0.1327 |
79789 | CLMN | P8T-E | Human | Esophagus | ESCC | 1.91e-13 | 1.92e-01 | 0.0889 |
79789 | CLMN | P10T-E | Human | Esophagus | ESCC | 4.61e-11 | 8.65e-02 | 0.116 |
79789 | CLMN | P11T-E | Human | Esophagus | ESCC | 3.14e-04 | 1.75e-01 | 0.1426 |
79789 | CLMN | P12T-E | Human | Esophagus | ESCC | 5.27e-05 | 1.16e-01 | 0.1122 |
79789 | CLMN | P15T-E | Human | Esophagus | ESCC | 1.82e-10 | 3.25e-01 | 0.1149 |
79789 | CLMN | P16T-E | Human | Esophagus | ESCC | 5.61e-31 | 7.16e-01 | 0.1153 |
79789 | CLMN | P17T-E | Human | Esophagus | ESCC | 6.50e-06 | 1.95e-01 | 0.1278 |
79789 | CLMN | P20T-E | Human | Esophagus | ESCC | 5.66e-07 | 1.46e-02 | 0.1124 |
79789 | CLMN | P21T-E | Human | Esophagus | ESCC | 9.14e-09 | 1.62e-01 | 0.1617 |
79789 | CLMN | P24T-E | Human | Esophagus | ESCC | 1.14e-09 | 1.14e-01 | 0.1287 |
79789 | CLMN | P26T-E | Human | Esophagus | ESCC | 8.25e-04 | 5.84e-02 | 0.1276 |
79789 | CLMN | P27T-E | Human | Esophagus | ESCC | 4.51e-09 | 1.37e-01 | 0.1055 |
79789 | CLMN | P28T-E | Human | Esophagus | ESCC | 4.65e-04 | 8.97e-02 | 0.1149 |
79789 | CLMN | P30T-E | Human | Esophagus | ESCC | 2.94e-02 | 1.75e-01 | 0.137 |
79789 | CLMN | P31T-E | Human | Esophagus | ESCC | 5.15e-03 | 1.46e-01 | 0.1251 |
79789 | CLMN | P32T-E | Human | Esophagus | ESCC | 2.41e-06 | 7.68e-02 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0007097 | Colorectum | AD | nuclear migration | 10/3918 | 20/18723 | 3.67e-03 | 2.60e-02 | 10 |
GO:0051647 | Colorectum | AD | nucleus localization | 11/3918 | 24/18723 | 5.43e-03 | 3.55e-02 | 11 |
GO:00516561 | Colorectum | SER | establishment of organelle localization | 100/2897 | 390/18723 | 1.11e-07 | 6.79e-06 | 100 |
GO:00070971 | Colorectum | SER | nuclear migration | 8/2897 | 20/18723 | 7.14e-03 | 4.99e-02 | 8 |
GO:00516471 | Colorectum | SER | nucleus localization | 9/2897 | 24/18723 | 7.19e-03 | 4.99e-02 | 9 |
GO:00516562 | Colorectum | MSS | establishment of organelle localization | 115/3467 | 390/18723 | 7.30e-08 | 3.67e-06 | 115 |
GO:00070972 | Colorectum | MSS | nuclear migration | 9/3467 | 20/18723 | 5.90e-03 | 3.98e-02 | 9 |
GO:00516472 | Colorectum | MSS | nucleus localization | 10/3467 | 24/18723 | 7.25e-03 | 4.63e-02 | 10 |
GO:00516563 | Colorectum | FAP | establishment of organelle localization | 97/2622 | 390/18723 | 5.91e-09 | 9.48e-07 | 97 |
GO:00070973 | Colorectum | FAP | nuclear migration | 9/2622 | 20/18723 | 7.94e-04 | 8.35e-03 | 9 |
GO:00516473 | Colorectum | FAP | nucleus localization | 9/2622 | 24/18723 | 3.66e-03 | 2.60e-02 | 9 |
GO:00516564 | Colorectum | CRC | establishment of organelle localization | 76/2078 | 390/18723 | 6.53e-07 | 4.50e-05 | 76 |
GO:00070974 | Colorectum | CRC | nuclear migration | 8/2078 | 20/18723 | 8.36e-04 | 1.04e-02 | 8 |
GO:00516474 | Colorectum | CRC | nucleus localization | 8/2078 | 24/18723 | 3.25e-03 | 2.81e-02 | 8 |
GO:005165616 | Esophagus | HGIN | establishment of organelle localization | 90/2587 | 390/18723 | 4.27e-07 | 1.94e-05 | 90 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:00070979 | Esophagus | ESCC | nuclear migration | 15/8552 | 20/18723 | 7.60e-03 | 2.71e-02 | 15 |
GO:00516478 | Esophagus | ESCC | nucleus localization | 17/8552 | 24/18723 | 1.13e-02 | 3.81e-02 | 17 |
GO:00070975 | Liver | NAFLD | nuclear migration | 7/1882 | 20/18723 | 2.44e-03 | 2.27e-02 | 7 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLMN | SNV | Missense_Mutation | c.2603N>T | p.Arg868Met | p.R868M | Q96JQ2 | protein_coding | deleterious(0) | possibly_damaging(0.862) | TCGA-A8-A07W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | exemestane | SD | |
CLMN | SNV | Missense_Mutation | rs747974986 | c.1189N>A | p.Asp397Asn | p.D397N | Q96JQ2 | protein_coding | tolerated(0.28) | benign(0.001) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CLMN | SNV | Missense_Mutation | c.304N>G | p.Lys102Glu | p.K102E | Q96JQ2 | protein_coding | deleterious(0.01) | possibly_damaging(0.699) | TCGA-AO-A0J8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
CLMN | SNV | Missense_Mutation | c.1762N>A | p.Glu588Lys | p.E588K | Q96JQ2 | protein_coding | tolerated_low_confidence(0.1) | benign(0.007) | TCGA-BH-A1F8-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
CLMN | SNV | Missense_Mutation | rs754251662 | c.731N>A | p.Arg244Gln | p.R244Q | Q96JQ2 | protein_coding | deleterious(0.05) | probably_damaging(0.965) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CLMN | insertion | Frame_Shift_Ins | novel | c.1799_1800insC | p.His601SerfsTer3 | p.H601Sfs*3 | Q96JQ2 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
CLMN | insertion | Frame_Shift_Ins | novel | c.1797_1798insGGTCCTGCCTGGGA | p.Asn600GlyfsTer11 | p.N600Gfs*11 | Q96JQ2 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
CLMN | insertion | Nonsense_Mutation | novel | c.499_500insGGTTGAGATCCTGGTGAATCATTTACCTTTCCAAGC | p.Ser167delinsTrpLeuArgSerTrpTerIleIleTyrLeuSerLysPro | p.S167delinsWLRSW*IIYLSKP | Q96JQ2 | protein_coding | TCGA-A8-A08S-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | ||
CLMN | insertion | Frame_Shift_Ins | novel | c.920_921insGTTTGTCCATCTTAACTTGAGGCTCTGG | p.Ile307MetfsTer23 | p.I307Mfs*23 | Q96JQ2 | protein_coding | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
CLMN | insertion | Frame_Shift_Ins | novel | c.2081_2082insCAGCAAACTACCA | p.Val695SerfsTer43 | p.V695Sfs*43 | Q96JQ2 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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