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Gene: CLIC3 |
Gene summary for CLIC3 |
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Gene information | Species | Human | Gene symbol | CLIC3 | Gene ID | 9022 |
Gene name | chloride intracellular channel 3 | |
Gene Alias | CLIC3 | |
Cytomap | 9q34.3 | |
Gene Type | protein-coding | GO ID | GO:0006518 | UniProtAcc | O95833 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9022 | CLIC3 | SYSMH4 | Human | Oral cavity | OSCC | 7.76e-06 | 2.13e-01 | 0.1226 |
9022 | CLIC3 | Pat02-B | Human | Stomach | GC | 4.73e-05 | 1.18e-01 | 0.0368 |
9022 | CLIC3 | Pat04-B | Human | Stomach | GC | 1.65e-12 | 3.74e-01 | -0.1483 |
9022 | CLIC3 | Pat06-B | Human | Stomach | GC | 1.17e-07 | 2.03e-01 | -0.1961 |
9022 | CLIC3 | Pat11-B | Human | Stomach | GC | 7.12e-07 | 3.41e-01 | -0.182 |
9022 | CLIC3 | Pat22-B | Human | Stomach | GC | 3.77e-17 | 3.91e-01 | -0.1042 |
9022 | CLIC3 | Pat24-B | Human | Stomach | GC | 1.47e-04 | 2.42e-01 | -0.1184 |
9022 | CLIC3 | Pat25-A | Human | Stomach | CAG with IM | 6.58e-08 | 1.72e-01 | -0.1648 |
9022 | CLIC3 | Pat26-A | Human | Stomach | CSG | 1.97e-09 | 2.32e-01 | -0.2402 |
9022 | CLIC3 | Pat28-A | Human | Stomach | CSG | 4.81e-09 | 3.46e-01 | -0.2594 |
9022 | CLIC3 | Pat29-A | Human | Stomach | CAG with IM | 3.25e-09 | 4.41e-01 | -0.2769 |
9022 | CLIC3 | Adj_PTCwithHT_6 | Human | Thyroid | HT | 3.14e-12 | -4.61e-01 | 0.02 |
9022 | CLIC3 | PTCwithHT_6 | Human | Thyroid | HT | 5.87e-04 | -2.78e-01 | 0.02 |
9022 | CLIC3 | PTCwithoutHT_2 | Human | Thyroid | PTC | 9.44e-08 | 5.52e-01 | 0.0419 |
9022 | CLIC3 | male-WTA | Human | Thyroid | PTC | 3.31e-63 | 4.12e-01 | 0.1037 |
9022 | CLIC3 | PTC01 | Human | Thyroid | PTC | 7.44e-21 | 1.29e+00 | 0.1899 |
9022 | CLIC3 | PTC04 | Human | Thyroid | PTC | 1.64e-04 | 1.14e+00 | 0.1927 |
9022 | CLIC3 | PTC05 | Human | Thyroid | PTC | 8.40e-31 | 2.74e+00 | 0.2065 |
9022 | CLIC3 | PTC06 | Human | Thyroid | PTC | 3.21e-44 | 2.46e+00 | 0.2057 |
9022 | CLIC3 | PTC07 | Human | Thyroid | PTC | 2.71e-73 | 2.30e+00 | 0.2044 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:00065757 | Esophagus | ESCC | cellular modified amino acid metabolic process | 112/8552 | 188/18723 | 8.31e-05 | 6.06e-04 | 112 |
GO:000674912 | Esophagus | ESCC | glutathione metabolic process | 42/8552 | 64/18723 | 1.01e-03 | 5.12e-03 | 42 |
GO:00067905 | Oral cavity | OSCC | sulfur compound metabolic process | 168/7305 | 339/18723 | 4.50e-05 | 3.84e-04 | 168 |
GO:00065756 | Oral cavity | OSCC | cellular modified amino acid metabolic process | 91/7305 | 188/18723 | 5.33e-03 | 2.07e-02 | 91 |
GO:0006749 | Stomach | GC | glutathione metabolic process | 13/1159 | 64/18723 | 1.25e-04 | 2.36e-03 | 13 |
GO:00067903 | Stomach | GC | sulfur compound metabolic process | 35/1159 | 339/18723 | 2.10e-03 | 2.10e-02 | 35 |
GO:00067491 | Stomach | CAG with IM | glutathione metabolic process | 12/1050 | 64/18723 | 1.99e-04 | 3.74e-03 | 12 |
GO:00067492 | Stomach | CSG | glutathione metabolic process | 12/1034 | 64/18723 | 1.73e-04 | 3.37e-03 | 12 |
GO:00065759 | Thyroid | HT | cellular modified amino acid metabolic process | 28/1272 | 188/18723 | 7.21e-05 | 1.31e-03 | 28 |
GO:00067499 | Thyroid | HT | glutathione metabolic process | 11/1272 | 64/18723 | 3.62e-03 | 2.74e-02 | 11 |
GO:000657513 | Thyroid | PTC | cellular modified amino acid metabolic process | 85/5968 | 188/18723 | 8.29e-05 | 7.01e-04 | 85 |
GO:000657522 | Thyroid | ATC | cellular modified amino acid metabolic process | 82/6293 | 188/18723 | 2.60e-03 | 1.20e-02 | 82 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLIC3 | SNV | Missense_Mutation | novel | c.215N>C | p.Lys72Thr | p.K72T | O95833 | protein_coding | deleterious(0) | probably_damaging(0.933) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CLIC3 | SNV | Missense_Mutation | c.235N>A | p.Glu79Lys | p.E79K | O95833 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
CLIC3 | SNV | Missense_Mutation | novel | c.90N>A | p.Met30Ile | p.M30I | O95833 | protein_coding | deleterious(0.02) | benign(0.005) | TCGA-VS-A9UZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CLIC3 | SNV | Missense_Mutation | c.176N>A | p.Gly59Asp | p.G59D | O95833 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
CLIC3 | SNV | Missense_Mutation | c.254N>T | p.Thr85Met | p.T85M | O95833 | protein_coding | tolerated(0.11) | benign(0.036) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CLIC3 | SNV | Missense_Mutation | c.275N>T | p.Pro92Leu | p.P92L | O95833 | protein_coding | tolerated(0.13) | probably_damaging(0.956) | TCGA-F4-6461-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
CLIC3 | SNV | Missense_Mutation | c.431C>T | p.Ala144Val | p.A144V | O95833 | protein_coding | deleterious(0.02) | benign(0.003) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CLIC3 | SNV | Missense_Mutation | novel | c.109N>A | p.Val37Ile | p.V37I | O95833 | protein_coding | deleterious(0.04) | benign(0.075) | TCGA-AJ-A8CT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLIC3 | SNV | Missense_Mutation | c.341N>T | p.Ala114Val | p.A114V | O95833 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CLIC3 | SNV | Missense_Mutation | novel | c.578N>T | p.Ala193Val | p.A193V | O95833 | protein_coding | deleterious(0.01) | benign(0) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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