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Gene: CHST12 |
Gene summary for CHST12 |
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Gene information | Species | Human | Gene symbol | CHST12 | Gene ID | 55501 |
Gene name | carbohydrate sulfotransferase 12 | |
Gene Alias | C4S-2 | |
Cytomap | 7p22.3 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | A0A024R860 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55501 | CHST12 | P52T-E | Human | Esophagus | ESCC | 7.65e-24 | 4.47e-01 | 0.1555 |
55501 | CHST12 | P54T-E | Human | Esophagus | ESCC | 1.63e-17 | 2.83e-01 | 0.0975 |
55501 | CHST12 | P56T-E | Human | Esophagus | ESCC | 1.44e-08 | 6.25e-01 | 0.1613 |
55501 | CHST12 | P57T-E | Human | Esophagus | ESCC | 1.32e-24 | 5.18e-01 | 0.0926 |
55501 | CHST12 | P61T-E | Human | Esophagus | ESCC | 7.55e-21 | 4.29e-01 | 0.099 |
55501 | CHST12 | P62T-E | Human | Esophagus | ESCC | 2.61e-43 | 6.87e-01 | 0.1302 |
55501 | CHST12 | P65T-E | Human | Esophagus | ESCC | 8.63e-21 | 4.49e-01 | 0.0978 |
55501 | CHST12 | P74T-E | Human | Esophagus | ESCC | 5.99e-26 | 7.16e-01 | 0.1479 |
55501 | CHST12 | P75T-E | Human | Esophagus | ESCC | 1.32e-47 | 8.28e-01 | 0.1125 |
55501 | CHST12 | P76T-E | Human | Esophagus | ESCC | 1.14e-21 | 3.90e-01 | 0.1207 |
55501 | CHST12 | P79T-E | Human | Esophagus | ESCC | 3.54e-17 | 3.58e-01 | 0.1154 |
55501 | CHST12 | P80T-E | Human | Esophagus | ESCC | 1.35e-37 | 8.44e-01 | 0.155 |
55501 | CHST12 | P82T-E | Human | Esophagus | ESCC | 1.35e-22 | 9.76e-01 | 0.1072 |
55501 | CHST12 | P83T-E | Human | Esophagus | ESCC | 4.22e-35 | 9.32e-01 | 0.1738 |
55501 | CHST12 | P84T-E | Human | Esophagus | ESCC | 2.68e-06 | 5.39e-01 | 0.0933 |
55501 | CHST12 | P89T-E | Human | Esophagus | ESCC | 8.77e-13 | 8.61e-01 | 0.1752 |
55501 | CHST12 | P91T-E | Human | Esophagus | ESCC | 1.08e-15 | 9.28e-01 | 0.1828 |
55501 | CHST12 | P107T-E | Human | Esophagus | ESCC | 3.04e-22 | 5.61e-01 | 0.171 |
55501 | CHST12 | P126T-E | Human | Esophagus | ESCC | 6.07e-04 | 4.34e-01 | 0.1125 |
55501 | CHST12 | P127T-E | Human | Esophagus | ESCC | 1.74e-10 | 2.11e-01 | 0.0826 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:00442725 | Esophagus | ESCC | sulfur compound biosynthetic process | 96/8552 | 148/18723 | 1.86e-06 | 2.16e-05 | 96 |
GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
GO:00160514 | Esophagus | ESCC | carbohydrate biosynthetic process | 117/8552 | 202/18723 | 2.96e-04 | 1.79e-03 | 117 |
GO:0006029 | Esophagus | ESCC | proteoglycan metabolic process | 48/8552 | 79/18723 | 4.93e-03 | 1.89e-02 | 48 |
GO:0030166 | Esophagus | ESCC | proteoglycan biosynthetic process | 35/8552 | 56/18723 | 8.30e-03 | 2.94e-02 | 35 |
GO:0006024 | Esophagus | ESCC | glycosaminoglycan biosynthetic process | 45/8552 | 75/18723 | 8.75e-03 | 3.08e-02 | 45 |
GO:0006023 | Esophagus | ESCC | aminoglycan biosynthetic process | 47/8552 | 79/18723 | 9.29e-03 | 3.23e-02 | 47 |
GO:000679011 | Liver | Cirrhotic | sulfur compound metabolic process | 129/4634 | 339/18723 | 3.06e-08 | 1.04e-06 | 129 |
GO:00442721 | Liver | Cirrhotic | sulfur compound biosynthetic process | 58/4634 | 148/18723 | 6.93e-05 | 7.83e-04 | 58 |
GO:00160511 | Liver | Cirrhotic | carbohydrate biosynthetic process | 73/4634 | 202/18723 | 1.91e-04 | 1.77e-03 | 73 |
GO:000679021 | Liver | HCC | sulfur compound metabolic process | 212/7958 | 339/18723 | 5.60e-14 | 3.39e-12 | 212 |
GO:00442722 | Liver | HCC | sulfur compound biosynthetic process | 95/7958 | 148/18723 | 7.89e-08 | 1.58e-06 | 95 |
GO:00160512 | Liver | HCC | carbohydrate biosynthetic process | 113/7958 | 202/18723 | 7.64e-05 | 6.83e-04 | 113 |
GO:0009100 | Liver | HCC | glycoprotein metabolic process | 193/7958 | 387/18723 | 1.89e-03 | 9.62e-03 | 193 |
GO:00442724 | Oral cavity | OSCC | sulfur compound biosynthetic process | 82/7305 | 148/18723 | 3.71e-05 | 3.31e-04 | 82 |
GO:00067905 | Oral cavity | OSCC | sulfur compound metabolic process | 168/7305 | 339/18723 | 4.50e-05 | 3.84e-04 | 168 |
GO:0030206 | Oral cavity | OSCC | chondroitin sulfate biosynthetic process | 15/7305 | 18/18723 | 1.53e-04 | 1.07e-03 | 15 |
GO:00091001 | Oral cavity | OSCC | glycoprotein metabolic process | 185/7305 | 387/18723 | 2.37e-04 | 1.54e-03 | 185 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00532 | Oral cavity | OSCC | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | 16/3704 | 21/8465 | 2.61e-03 | 6.77e-03 | 3.45e-03 | 16 |
hsa005321 | Oral cavity | OSCC | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | 16/3704 | 21/8465 | 2.61e-03 | 6.77e-03 | 3.45e-03 | 16 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHST12 | SNV | Missense_Mutation | novel | c.1121G>A | p.Ser374Asn | p.S374N | Q9NRB3 | protein_coding | tolerated(0.25) | probably_damaging(0.94) | TCGA-A8-A08P-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
CHST12 | SNV | Missense_Mutation | c.240G>C | p.Gln80His | p.Q80H | Q9NRB3 | protein_coding | tolerated(0.17) | benign(0) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
CHST12 | SNV | Missense_Mutation | c.1027G>A | p.Glu343Lys | p.E343K | Q9NRB3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
CHST12 | SNV | Missense_Mutation | c.661N>T | p.Arg221Cys | p.R221C | Q9NRB3 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHST12 | SNV | Missense_Mutation | c.937N>A | p.Glu313Lys | p.E313K | Q9NRB3 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CHST12 | SNV | Missense_Mutation | c.430C>T | p.Arg144Cys | p.R144C | Q9NRB3 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CHST12 | SNV | Missense_Mutation | rs756193680 | c.143N>T | p.Pro48Leu | p.P48L | Q9NRB3 | protein_coding | tolerated(0.13) | benign(0) | TCGA-DY-A1DD-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CHST12 | SNV | Missense_Mutation | novel | c.884G>A | p.Gly295Asp | p.G295D | Q9NRB3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CHST12 | SNV | Missense_Mutation | rs769324562 | c.263C>T | p.Thr88Met | p.T88M | Q9NRB3 | protein_coding | tolerated(0.1) | benign(0.186) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHST12 | SNV | Missense_Mutation | novel | c.464N>A | p.Ser155Asn | p.S155N | Q9NRB3 | protein_coding | tolerated(0.91) | benign(0) | TCGA-A5-A2K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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