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Gene: CFAP97 |
Gene summary for CFAP97 |
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Gene information | Species | Human | Gene symbol | CFAP97 | Gene ID | 57587 |
Gene name | cilia and flagella associated protein 97 | |
Gene Alias | KIAA1430 | |
Cytomap | 4q35.1 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q9P2B7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57587 | CFAP97 | P48T-E | Human | Esophagus | ESCC | 5.80e-17 | 2.81e-01 | 0.0959 |
57587 | CFAP97 | P49T-E | Human | Esophagus | ESCC | 3.65e-15 | 1.43e+00 | 0.1768 |
57587 | CFAP97 | P52T-E | Human | Esophagus | ESCC | 1.17e-25 | 5.60e-01 | 0.1555 |
57587 | CFAP97 | P54T-E | Human | Esophagus | ESCC | 5.07e-38 | 8.34e-01 | 0.0975 |
57587 | CFAP97 | P56T-E | Human | Esophagus | ESCC | 8.15e-08 | 1.33e+00 | 0.1613 |
57587 | CFAP97 | P57T-E | Human | Esophagus | ESCC | 2.06e-15 | 3.38e-01 | 0.0926 |
57587 | CFAP97 | P61T-E | Human | Esophagus | ESCC | 1.98e-09 | 1.27e-01 | 0.099 |
57587 | CFAP97 | P62T-E | Human | Esophagus | ESCC | 1.95e-40 | 7.69e-01 | 0.1302 |
57587 | CFAP97 | P65T-E | Human | Esophagus | ESCC | 2.03e-26 | 4.51e-01 | 0.0978 |
57587 | CFAP97 | P74T-E | Human | Esophagus | ESCC | 3.00e-26 | 7.94e-01 | 0.1479 |
57587 | CFAP97 | P75T-E | Human | Esophagus | ESCC | 2.29e-11 | 2.86e-01 | 0.1125 |
57587 | CFAP97 | P76T-E | Human | Esophagus | ESCC | 7.52e-35 | 6.96e-01 | 0.1207 |
57587 | CFAP97 | P79T-E | Human | Esophagus | ESCC | 3.73e-24 | 4.91e-01 | 0.1154 |
57587 | CFAP97 | P80T-E | Human | Esophagus | ESCC | 1.45e-66 | 2.06e+00 | 0.155 |
57587 | CFAP97 | P82T-E | Human | Esophagus | ESCC | 1.04e-11 | 6.58e-01 | 0.1072 |
57587 | CFAP97 | P83T-E | Human | Esophagus | ESCC | 7.82e-48 | 1.24e+00 | 0.1738 |
57587 | CFAP97 | P89T-E | Human | Esophagus | ESCC | 1.48e-12 | 8.38e-01 | 0.1752 |
57587 | CFAP97 | P91T-E | Human | Esophagus | ESCC | 1.78e-12 | 1.40e+00 | 0.1828 |
57587 | CFAP97 | P107T-E | Human | Esophagus | ESCC | 1.36e-32 | 6.28e-01 | 0.171 |
57587 | CFAP97 | P126T-E | Human | Esophagus | ESCC | 1.07e-07 | 5.34e-01 | 0.1125 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CFAP97 | SNV | Missense_Mutation | rs781085964 | c.1205C>T | p.Ala402Val | p.A402V | Q9P2B7 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CFAP97 | SNV | Missense_Mutation | c.615N>T | p.Lys205Asn | p.K205N | Q9P2B7 | protein_coding | tolerated(0.32) | benign(0.001) | TCGA-D8-A27W-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
CFAP97 | SNV | Missense_Mutation | c.608N>T | p.Ser203Leu | p.S203L | Q9P2B7 | protein_coding | tolerated(0.1) | benign(0.036) | TCGA-E2-A14V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
CFAP97 | insertion | Nonsense_Mutation | novel | c.825_826insCATTCCCAACAATAAAAAATATCTACTA | p.Asp276HisfsTer5 | p.D276Hfs*5 | Q9P2B7 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CFAP97 | SNV | Missense_Mutation | rs373566490 | c.158N>T | p.Ser53Leu | p.S53L | Q9P2B7 | protein_coding | tolerated(0.61) | benign(0) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CFAP97 | SNV | Missense_Mutation | rs777547282 | c.1397N>A | p.Arg466His | p.R466H | Q9P2B7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CFAP97 | SNV | Missense_Mutation | c.775N>C | p.Ser259Pro | p.S259P | Q9P2B7 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CFAP97 | SNV | Missense_Mutation | c.53N>G | p.Asp18Gly | p.D18G | Q9P2B7 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CFAP97 | SNV | Missense_Mutation | novel | c.1069N>A | p.Asp357Asn | p.D357N | Q9P2B7 | protein_coding | tolerated(0.11) | probably_damaging(0.911) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CFAP97 | SNV | Missense_Mutation | novel | c.495N>T | p.Lys165Asn | p.K165N | Q9P2B7 | protein_coding | deleterious(0.01) | benign(0.071) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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