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Gene: CFAP44 |
Gene summary for CFAP44 |
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Gene information | Species | Human | Gene symbol | CFAP44 | Gene ID | 55779 |
Gene name | cilia and flagella associated protein 44 | |
Gene Alias | SPGF20 | |
Cytomap | 3q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q96MT7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55779 | CFAP44 | A002-C-016 | Human | Colorectum | FAP | 3.78e-16 | 7.34e-02 | 0.0521 |
55779 | CFAP44 | A015-C-002 | Human | Colorectum | FAP | 4.33e-07 | 2.20e-01 | -0.0763 |
55779 | CFAP44 | A001-C-203 | Human | Colorectum | FAP | 4.63e-11 | 2.25e-01 | -0.0481 |
55779 | CFAP44 | A002-C-116 | Human | Colorectum | FAP | 1.46e-23 | -8.91e-02 | -0.0452 |
55779 | CFAP44 | A014-C-008 | Human | Colorectum | FAP | 1.72e-10 | 2.20e-01 | -0.191 |
55779 | CFAP44 | A018-E-020 | Human | Colorectum | FAP | 2.23e-13 | 4.37e-02 | -0.2034 |
55779 | CFAP44 | F034 | Human | Colorectum | FAP | 2.71e-17 | 2.06e-01 | -0.0665 |
55779 | CFAP44 | F072B | Human | Colorectum | FAP | 3.28e-03 | 8.42e-02 | 0.257 |
55779 | CFAP44 | CRC-1-8810 | Human | Colorectum | CRC | 2.39e-05 | -1.62e-01 | 0.6257 |
55779 | CFAP44 | CRC-3-11773 | Human | Colorectum | CRC | 4.84e-09 | -3.45e-01 | 0.2564 |
55779 | CFAP44 | NAFLD1 | Human | Liver | NAFLD | 9.09e-05 | 5.87e-01 | -0.04 |
55779 | CFAP44 | HCC1_Meng | Human | Liver | HCC | 1.62e-06 | -2.54e-02 | 0.0246 |
55779 | CFAP44 | HCC2_Meng | Human | Liver | HCC | 6.71e-04 | 4.70e-02 | 0.0107 |
55779 | CFAP44 | HCC2 | Human | Liver | HCC | 2.67e-04 | 3.05e+00 | 0.5341 |
55779 | CFAP44 | HTA12-23-1 | Human | Pancreas | PDAC | 1.36e-02 | 4.80e-01 | 0.3405 |
55779 | CFAP44 | HTA12-26-1 | Human | Pancreas | PDAC | 5.68e-08 | 5.16e-01 | 0.3728 |
55779 | CFAP44 | HTA12-29-1 | Human | Pancreas | PDAC | 2.07e-22 | 5.31e-01 | 0.3722 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CFAP44 | SNV | Missense_Mutation | novel | c.3028G>C | p.Glu1010Gln | p.E1010Q | protein_coding | tolerated(0.09) | possibly_damaging(0.629) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD | |
CFAP44 | SNV | Missense_Mutation | novel | c.3680N>G | p.Val1227Gly | p.V1227G | protein_coding | deleterious(0) | possibly_damaging(0.801) | TCGA-A2-A04Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
CFAP44 | SNV | Missense_Mutation | rs200395263 | c.3146N>G | p.Val1049Gly | p.V1049G | protein_coding | deleterious(0.01) | possibly_damaging(0.73) | TCGA-A2-A04Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
CFAP44 | SNV | Missense_Mutation | c.2246N>A | p.Ser749Tyr | p.S749Y | protein_coding | deleterious(0) | possibly_damaging(0.804) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
CFAP44 | SNV | Missense_Mutation | c.3650T>C | p.Ile1217Thr | p.I1217T | protein_coding | deleterious(0) | possibly_damaging(0.86) | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
CFAP44 | SNV | Missense_Mutation | novel | c.3680N>G | p.Val1227Gly | p.V1227G | protein_coding | deleterious(0) | possibly_damaging(0.801) | TCGA-A2-A0T2-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | PD | |
CFAP44 | SNV | Missense_Mutation | rs200395263 | c.3146N>G | p.Val1049Gly | p.V1049G | protein_coding | deleterious(0.01) | possibly_damaging(0.73) | TCGA-A2-A0T2-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | PD | |
CFAP44 | SNV | Missense_Mutation | rs200395263 | c.3146N>G | p.Val1049Gly | p.V1049G | protein_coding | deleterious(0.01) | possibly_damaging(0.73) | TCGA-A2-A0T5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Taxotere | SD | |
CFAP44 | SNV | Missense_Mutation | novel | c.3680T>G | p.Val1227Gly | p.V1227G | protein_coding | deleterious(0) | possibly_damaging(0.801) | TCGA-A2-A1G4-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | adriamycin | SD | |
CFAP44 | SNV | Missense_Mutation | c.218G>T | p.Ser73Ile | p.S73I | protein_coding | deleterious_low_confidence(0.01) | benign(0.316) | TCGA-AN-A04D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
55779 | CFAP44 | PROTEASE | hmg coa reductase inhibitors | 25602530 |
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