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Gene: CEP41 |
Gene summary for CEP41 |
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Gene information | Species | Human | Gene symbol | CEP41 | Gene ID | 95681 |
Gene name | centrosomal protein 41 | |
Gene Alias | JBTS15 | |
Cytomap | 7q32.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9BYV8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
95681 | CEP41 | P107T-E | Human | Esophagus | ESCC | 1.03e-04 | 1.66e-01 | 0.171 |
95681 | CEP41 | P128T-E | Human | Esophagus | ESCC | 4.38e-03 | 2.05e-01 | 0.1241 |
95681 | CEP41 | HCC1_Meng | Human | Liver | HCC | 1.59e-25 | 5.36e-02 | 0.0246 |
95681 | CEP41 | HCC2_Meng | Human | Liver | HCC | 1.05e-13 | 5.60e-02 | 0.0107 |
95681 | CEP41 | HCC1 | Human | Liver | HCC | 8.11e-07 | 4.09e+00 | 0.5336 |
95681 | CEP41 | HCC2 | Human | Liver | HCC | 7.20e-07 | 2.91e+00 | 0.5341 |
95681 | CEP41 | Pt13.b | Human | Liver | HCC | 5.53e-03 | 9.50e-02 | 0.0251 |
95681 | CEP41 | S014 | Human | Liver | HCC | 2.12e-14 | 3.90e-01 | 0.2254 |
95681 | CEP41 | S015 | Human | Liver | HCC | 4.18e-11 | 4.00e-01 | 0.2375 |
95681 | CEP41 | S016 | Human | Liver | HCC | 4.09e-14 | 3.12e-01 | 0.2243 |
95681 | CEP41 | S028 | Human | Liver | HCC | 1.30e-12 | 4.18e-01 | 0.2503 |
95681 | CEP41 | S029 | Human | Liver | HCC | 1.46e-08 | 2.74e-01 | 0.2581 |
95681 | CEP41 | C04 | Human | Oral cavity | OSCC | 1.34e-08 | 5.63e-01 | 0.2633 |
95681 | CEP41 | C21 | Human | Oral cavity | OSCC | 4.91e-08 | 3.89e-01 | 0.2678 |
95681 | CEP41 | C30 | Human | Oral cavity | OSCC | 4.02e-08 | 5.56e-01 | 0.3055 |
95681 | CEP41 | C51 | Human | Oral cavity | OSCC | 8.75e-07 | 4.72e-01 | 0.2674 |
95681 | CEP41 | C08 | Human | Oral cavity | OSCC | 1.23e-10 | 2.73e-01 | 0.1919 |
95681 | CEP41 | SYSMH6 | Human | Oral cavity | OSCC | 4.17e-06 | 2.24e-01 | 0.1275 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CEP41 | SNV | Missense_Mutation | rs782089459 | c.1028G>A | p.Arg343Gln | p.R343Q | Q9BYV8 | protein_coding | deleterious(0.03) | benign(0.441) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CEP41 | SNV | Missense_Mutation | c.676N>A | p.Asp226Asn | p.D226N | Q9BYV8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A1FC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CEP41 | SNV | Missense_Mutation | c.349G>A | p.Glu117Lys | p.E117K | Q9BYV8 | protein_coding | tolerated(0.53) | benign(0.079) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
CEP41 | SNV | Missense_Mutation | rs138907207 | c.130N>A | p.Glu44Lys | p.E44K | Q9BYV8 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-FU-A3NI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CEP41 | SNV | Missense_Mutation | c.670N>G | p.Leu224Val | p.L224V | Q9BYV8 | protein_coding | tolerated(0.67) | benign(0.078) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
CEP41 | SNV | Missense_Mutation | novel | c.584N>G | p.Tyr195Cys | p.Y195C | Q9BYV8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CEP41 | SNV | Missense_Mutation | c.900G>T | p.Trp300Cys | p.W300C | Q9BYV8 | protein_coding | tolerated(0.18) | benign(0.119) | TCGA-AA-3941-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CEP41 | SNV | Missense_Mutation | c.935N>G | p.Tyr312Cys | p.Y312C | Q9BYV8 | protein_coding | tolerated(0.17) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CEP41 | SNV | Missense_Mutation | c.160N>C | p.Lys54Gln | p.K54Q | Q9BYV8 | protein_coding | deleterious(0.03) | possibly_damaging(0.527) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
CEP41 | SNV | Missense_Mutation | c.391G>A | p.Ala131Thr | p.A131T | Q9BYV8 | protein_coding | tolerated(0.19) | benign(0.006) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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