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Gene: CENPU |
Gene summary for CENPU |
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Gene information | Species | Human | Gene symbol | CENPU | Gene ID | 79682 |
Gene name | centromere protein U | |
Gene Alias | CENP50 | |
Cytomap | 4q35.1 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | Q71F23 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79682 | CENPU | P91T-E | Human | Esophagus | ESCC | 1.31e-15 | 2.33e+00 | 0.1828 |
79682 | CENPU | P107T-E | Human | Esophagus | ESCC | 1.46e-10 | 2.69e-01 | 0.171 |
79682 | CENPU | P128T-E | Human | Esophagus | ESCC | 4.29e-03 | 1.66e-01 | 0.1241 |
79682 | CENPU | P130T-E | Human | Esophagus | ESCC | 1.35e-23 | 5.72e-01 | 0.1676 |
79682 | CENPU | HCC1_Meng | Human | Liver | HCC | 2.25e-11 | 2.41e-02 | 0.0246 |
79682 | CENPU | HCC2 | Human | Liver | HCC | 1.15e-12 | 4.04e+00 | 0.5341 |
79682 | CENPU | S014 | Human | Liver | HCC | 2.43e-03 | 2.05e-01 | 0.2254 |
79682 | CENPU | S028 | Human | Liver | HCC | 7.63e-11 | 5.78e-01 | 0.2503 |
79682 | CENPU | C04 | Human | Oral cavity | OSCC | 5.62e-10 | 6.68e-01 | 0.2633 |
79682 | CENPU | C21 | Human | Oral cavity | OSCC | 1.30e-16 | 8.92e-01 | 0.2678 |
79682 | CENPU | C30 | Human | Oral cavity | OSCC | 1.99e-13 | 1.03e+00 | 0.3055 |
79682 | CENPU | C38 | Human | Oral cavity | OSCC | 1.17e-04 | 1.15e+00 | 0.172 |
79682 | CENPU | C43 | Human | Oral cavity | OSCC | 3.68e-38 | 7.52e-01 | 0.1704 |
79682 | CENPU | C46 | Human | Oral cavity | OSCC | 2.26e-38 | 9.12e-01 | 0.1673 |
79682 | CENPU | C51 | Human | Oral cavity | OSCC | 6.99e-03 | 3.36e-01 | 0.2674 |
79682 | CENPU | C57 | Human | Oral cavity | OSCC | 1.82e-15 | 5.34e-01 | 0.1679 |
79682 | CENPU | C08 | Human | Oral cavity | OSCC | 7.27e-06 | 2.82e-01 | 0.1919 |
79682 | CENPU | LN22 | Human | Oral cavity | OSCC | 3.85e-03 | 5.68e-01 | 0.1733 |
79682 | CENPU | LN46 | Human | Oral cavity | OSCC | 1.12e-31 | 1.06e+00 | 0.1666 |
79682 | CENPU | SYSMH2 | Human | Oral cavity | OSCC | 3.47e-05 | 2.44e-01 | 0.2326 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CENPU | SNV | Missense_Mutation | novel | c.1102N>G | p.Tyr368Asp | p.Y368D | Q71F23 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-A7-A26I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
CENPU | insertion | Nonsense_Mutation | novel | c.1103_1104insAA | p.Tyr368Ter | p.Y368* | Q71F23 | protein_coding | TCGA-A7-A26I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
CENPU | insertion | Frame_Shift_Ins | novel | c.129_130insACGTG | p.Phe44ThrfsTer80 | p.F44Tfs*80 | Q71F23 | protein_coding | TCGA-C8-A131-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR | ||
CENPU | SNV | Missense_Mutation | c.945N>T | p.Lys315Asn | p.K315N | Q71F23 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
CENPU | SNV | Missense_Mutation | rs200975207 | c.1132N>A | p.Val378Ile | p.V378I | Q71F23 | protein_coding | tolerated(0.23) | benign(0) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CENPU | SNV | Missense_Mutation | c.77G>T | p.Arg26Ile | p.R26I | Q71F23 | protein_coding | deleterious(0) | possibly_damaging(0.548) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CENPU | SNV | Missense_Mutation | c.955N>T | p.Arg319Cys | p.R319C | Q71F23 | protein_coding | deleterious(0.05) | benign(0.3) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CENPU | SNV | Missense_Mutation | c.439A>G | p.Thr147Ala | p.T147A | Q71F23 | protein_coding | tolerated(0.06) | benign(0.061) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
CENPU | SNV | Missense_Mutation | novel | c.527N>G | p.Lys176Arg | p.K176R | Q71F23 | protein_coding | tolerated(0.14) | benign(0.031) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CENPU | SNV | Missense_Mutation | novel | c.317N>T | p.Arg106Ile | p.R106I | Q71F23 | protein_coding | tolerated(0.09) | benign(0.276) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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