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Gene: CEBPZOS |
Gene summary for CEBPZOS |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CEBPZOS | Gene ID | 100505876 |
| Gene name | CEBPZ opposite strand | |
| Gene Alias | CEBPZ-AS1 | |
| Cytomap | 2p22.2 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A8MTT3 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 100505876 | CEBPZOS | P48T-E | Human | Esophagus | ESCC | 7.72e-25 | 5.65e-01 | 0.0959 |
| 100505876 | CEBPZOS | P49T-E | Human | Esophagus | ESCC | 1.31e-08 | 1.34e+00 | 0.1768 |
| 100505876 | CEBPZOS | P52T-E | Human | Esophagus | ESCC | 1.30e-31 | 7.39e-01 | 0.1555 |
| 100505876 | CEBPZOS | P54T-E | Human | Esophagus | ESCC | 7.38e-23 | 6.99e-01 | 0.0975 |
| 100505876 | CEBPZOS | P57T-E | Human | Esophagus | ESCC | 3.29e-23 | 5.55e-01 | 0.0926 |
| 100505876 | CEBPZOS | P61T-E | Human | Esophagus | ESCC | 3.06e-11 | 4.73e-01 | 0.099 |
| 100505876 | CEBPZOS | P62T-E | Human | Esophagus | ESCC | 4.12e-34 | 7.15e-01 | 0.1302 |
| 100505876 | CEBPZOS | P65T-E | Human | Esophagus | ESCC | 2.54e-13 | 2.98e-01 | 0.0978 |
| 100505876 | CEBPZOS | P74T-E | Human | Esophagus | ESCC | 2.78e-26 | 9.95e-01 | 0.1479 |
| 100505876 | CEBPZOS | P75T-E | Human | Esophagus | ESCC | 6.27e-37 | 7.97e-01 | 0.1125 |
| 100505876 | CEBPZOS | P76T-E | Human | Esophagus | ESCC | 2.06e-29 | 6.06e-01 | 0.1207 |
| 100505876 | CEBPZOS | P79T-E | Human | Esophagus | ESCC | 3.79e-24 | 6.40e-01 | 0.1154 |
| 100505876 | CEBPZOS | P80T-E | Human | Esophagus | ESCC | 1.02e-25 | 8.93e-01 | 0.155 |
| 100505876 | CEBPZOS | P82T-E | Human | Esophagus | ESCC | 2.37e-12 | 7.82e-01 | 0.1072 |
| 100505876 | CEBPZOS | P83T-E | Human | Esophagus | ESCC | 1.53e-23 | 9.36e-01 | 0.1738 |
| 100505876 | CEBPZOS | P84T-E | Human | Esophagus | ESCC | 1.73e-04 | 5.71e-01 | 0.0933 |
| 100505876 | CEBPZOS | P89T-E | Human | Esophagus | ESCC | 2.06e-15 | 1.15e+00 | 0.1752 |
| 100505876 | CEBPZOS | P91T-E | Human | Esophagus | ESCC | 4.18e-02 | 7.71e-01 | 0.1828 |
| 100505876 | CEBPZOS | P107T-E | Human | Esophagus | ESCC | 6.07e-38 | 1.02e+00 | 0.171 |
| 100505876 | CEBPZOS | P126T-E | Human | Esophagus | ESCC | 1.58e-03 | 7.11e-01 | 0.1125 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CEBPZOS | SNV | Missense_Mutation | novel | c.203N>A | p.Arg68Lys | p.R68K | A8MTT3 | protein_coding | deleterious(0) | probably_damaging(0.921) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
| CEBPZOS | SNV | Missense_Mutation | novel | c.58G>A | p.Glu20Lys | p.E20K | A8MTT3 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| CEBPZOS | SNV | Missense_Mutation | novel | c.58N>A | p.Glu20Lys | p.E20K | A8MTT3 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
| CEBPZOS | SNV | Missense_Mutation | novel | c.58N>A | p.Glu20Lys | p.E20K | A8MTT3 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| CEBPZOS | SNV | Missense_Mutation | novel | c.31N>G | p.Lys11Glu | p.K11E | A8MTT3 | protein_coding | tolerated(0.09) | possibly_damaging(0.896) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| CEBPZOS | SNV | Missense_Mutation | novel | c.58N>A | p.Glu20Lys | p.E20K | A8MTT3 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| CEBPZOS | SNV | Missense_Mutation | novel | c.58N>A | p.Glu20Lys | p.E20K | A8MTT3 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
| CEBPZOS | SNV | Missense_Mutation | novel | c.5N>T | p.Ala2Val | p.A2V | A8MTT3 | protein_coding | tolerated(0.08) | benign(0.025) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| CEBPZOS | SNV | Missense_Mutation | novel | c.58N>A | p.Glu20Lys | p.E20K | A8MTT3 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| CEBPZOS | SNV | Missense_Mutation | novel | c.58N>A | p.Glu20Lys | p.E20K | A8MTT3 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
| Page: 1 2 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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