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Gene: CDHR1 |
Gene summary for CDHR1 |
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Gene information | Species | Human | Gene symbol | CDHR1 | Gene ID | 92211 |
Gene name | cadherin related family member 1 | |
Gene Alias | CORD15 | |
Cytomap | 10q23.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | F1T0L2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
92211 | CDHR1 | cSCC_p11 | Human | Skin | cSCC | 1.64e-21 | 6.52e-01 | -0.2102 |
92211 | CDHR1 | cSCC_p4 | Human | Skin | cSCC | 6.91e-30 | 5.98e-01 | -0.2022 |
92211 | CDHR1 | cSCC_p6 | Human | Skin | cSCC | 2.31e-06 | 2.76e-01 | -0.1989 |
92211 | CDHR1 | cSCC_p7 | Human | Skin | cSCC | 2.76e-23 | 7.50e-01 | -0.2332 |
92211 | CDHR1 | cSCC_p8 | Human | Skin | cSCC | 2.72e-15 | 3.83e-01 | -0.1971 |
92211 | CDHR1 | cSCC_p9 | Human | Skin | cSCC | 4.21e-13 | 3.56e-01 | -0.1991 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0060249 | Colorectum | AD | anatomical structure homeostasis | 94/3918 | 314/18723 | 9.37e-05 | 1.42e-03 | 94 |
GO:0001894 | Colorectum | AD | tissue homeostasis | 81/3918 | 268/18723 | 1.96e-04 | 2.62e-03 | 81 |
GO:00018941 | Colorectum | SER | tissue homeostasis | 66/2897 | 268/18723 | 5.87e-05 | 1.37e-03 | 66 |
GO:00602491 | Colorectum | SER | anatomical structure homeostasis | 74/2897 | 314/18723 | 1.01e-04 | 2.13e-03 | 74 |
GO:00602492 | Colorectum | MSS | anatomical structure homeostasis | 84/3467 | 314/18723 | 1.87e-04 | 2.64e-03 | 84 |
GO:00018942 | Colorectum | MSS | tissue homeostasis | 72/3467 | 268/18723 | 4.53e-04 | 5.40e-03 | 72 |
GO:00018944 | Colorectum | FAP | tissue homeostasis | 61/2622 | 268/18723 | 6.71e-05 | 1.28e-03 | 61 |
GO:00602494 | Colorectum | FAP | anatomical structure homeostasis | 69/2622 | 314/18723 | 7.51e-05 | 1.37e-03 | 69 |
GO:00602495 | Colorectum | CRC | anatomical structure homeostasis | 57/2078 | 314/18723 | 1.24e-04 | 2.41e-03 | 57 |
GO:00018945 | Colorectum | CRC | tissue homeostasis | 48/2078 | 268/18723 | 5.56e-04 | 7.70e-03 | 48 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDHR1 | SNV | Missense_Mutation | novel | c.974N>C | p.Met325Thr | p.M325T | Q96JP9 | protein_coding | deleterious(0) | benign(0.033) | TCGA-AC-A8OP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CDHR1 | SNV | Missense_Mutation | c.232N>G | p.Arg78Gly | p.R78G | Q96JP9 | protein_coding | tolerated(0.36) | possibly_damaging(0.801) | TCGA-AN-A0AJ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CDHR1 | SNV | Missense_Mutation | novel | c.958N>A | p.Val320Ile | p.V320I | Q96JP9 | protein_coding | tolerated(0.31) | benign(0.094) | TCGA-BH-A1EW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CDHR1 | SNV | Missense_Mutation | c.592N>G | p.Leu198Val | p.L198V | Q96JP9 | protein_coding | deleterious(0) | possibly_damaging(0.901) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CDHR1 | SNV | Missense_Mutation | novel | c.709G>A | p.Glu237Lys | p.E237K | Q96JP9 | protein_coding | tolerated(0.88) | benign(0.16) | TCGA-E2-A159-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
CDHR1 | insertion | Frame_Shift_Ins | novel | c.2092_2093insTCTCTGCAACGTGGGCAGAGCGAGAAGGACCATCT | p.Pro698LeufsTer14 | p.P698Lfs*14 | Q96JP9 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
CDHR1 | insertion | Frame_Shift_Ins | novel | c.581_582insCAGAGCTAAGCCCAAAGCTGAGCCCAAGAAAATT | p.Gly195ArgfsTer40 | p.G195Rfs*40 | Q96JP9 | protein_coding | TCGA-AN-A03Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CDHR1 | insertion | Frame_Shift_Ins | novel | c.1639_1640insTCAGGAGGCAGCTCATTATTGCAGGC | p.Tyr547PhefsTer11 | p.Y547Ffs*11 | Q96JP9 | protein_coding | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
CDHR1 | SNV | Missense_Mutation | novel | c.2506N>A | p.Val836Ile | p.V836I | Q96JP9 | protein_coding | tolerated_low_confidence(0.66) | benign(0) | TCGA-C5-A7XC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CDHR1 | SNV | Missense_Mutation | c.1399G>A | p.Asp467Asn | p.D467N | Q96JP9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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