![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CD47 |
Gene summary for CD47 |
![]() |
Gene information | Species | Human | Gene symbol | CD47 | Gene ID | 961 |
Gene name | CD47 molecule | |
Gene Alias | IAP | |
Cytomap | 3q13.12 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q08722 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
961 | CD47 | sample3 | Human | Cervix | CC | 5.92e-25 | 6.18e-01 | 0.1387 |
961 | CD47 | H2 | Human | Cervix | HSIL_HPV | 8.41e-07 | -3.00e-01 | 0.0632 |
961 | CD47 | L1 | Human | Cervix | CC | 2.12e-04 | 5.94e-02 | 0.0802 |
961 | CD47 | T3 | Human | Cervix | CC | 4.46e-21 | 6.22e-01 | 0.1389 |
961 | CD47 | AEH-subject1 | Human | Endometrium | AEH | 3.01e-03 | 3.09e-01 | -0.3059 |
961 | CD47 | AEH-subject2 | Human | Endometrium | AEH | 6.74e-09 | 4.41e-01 | -0.2525 |
961 | CD47 | AEH-subject3 | Human | Endometrium | AEH | 1.32e-02 | 2.41e-01 | -0.2576 |
961 | CD47 | AEH-subject4 | Human | Endometrium | AEH | 4.90e-12 | 5.30e-01 | -0.2657 |
961 | CD47 | AEH-subject5 | Human | Endometrium | AEH | 6.34e-03 | 2.91e-01 | -0.2953 |
961 | CD47 | EEC-subject2 | Human | Endometrium | EEC | 1.47e-15 | 5.43e-01 | -0.2607 |
961 | CD47 | EEC-subject3 | Human | Endometrium | EEC | 2.85e-04 | 1.17e-02 | -0.2525 |
961 | CD47 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 6.80e-17 | 3.28e-01 | -0.1869 |
961 | CD47 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 2.67e-13 | 2.74e-01 | -0.1875 |
961 | CD47 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.09e-20 | 3.82e-01 | -0.1883 |
961 | CD47 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 5.15e-13 | 3.07e-01 | -0.1934 |
961 | CD47 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 4.73e-22 | 3.30e-01 | -0.1917 |
961 | CD47 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 3.08e-29 | 4.04e-01 | -0.1916 |
961 | CD47 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 1.19e-43 | 8.87e-01 | -0.1269 |
961 | CD47 | LZE4T | Human | Esophagus | ESCC | 6.32e-14 | 2.60e-01 | 0.0811 |
961 | CD47 | LZE7T | Human | Esophagus | ESCC | 7.61e-05 | 5.11e-02 | 0.0667 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00975297 | Breast | Precancer | myeloid leukocyte migration | 34/1080 | 220/18723 | 1.42e-07 | 7.82e-06 | 34 |
GO:00509006 | Breast | Precancer | leukocyte migration | 47/1080 | 369/18723 | 2.82e-07 | 1.39e-05 | 47 |
GO:00457859 | Breast | Precancer | positive regulation of cell adhesion | 52/1080 | 437/18723 | 5.74e-07 | 2.49e-05 | 52 |
GO:00507293 | Breast | Precancer | positive regulation of inflammatory response | 23/1080 | 142/18723 | 6.51e-06 | 1.81e-04 | 23 |
GO:0050727 | Breast | Precancer | regulation of inflammatory response | 44/1080 | 386/18723 | 1.26e-05 | 3.22e-04 | 44 |
GO:00421107 | Breast | Precancer | T cell activation | 52/1080 | 487/18723 | 1.37e-05 | 3.42e-04 | 52 |
GO:00508707 | Breast | Precancer | positive regulation of T cell activation | 29/1080 | 216/18723 | 1.94e-05 | 4.58e-04 | 29 |
GO:19029059 | Breast | Precancer | positive regulation of supramolecular fiber organization | 28/1080 | 209/18723 | 2.79e-05 | 6.28e-04 | 28 |
GO:00321034 | Breast | Precancer | positive regulation of response to external stimulus | 46/1080 | 427/18723 | 3.41e-05 | 7.40e-04 | 46 |
GO:19029039 | Breast | Precancer | regulation of supramolecular fiber organization | 42/1080 | 383/18723 | 4.92e-05 | 1.04e-03 | 42 |
GO:19030396 | Breast | Precancer | positive regulation of leukocyte cell-cell adhesion | 30/1080 | 239/18723 | 5.13e-05 | 1.07e-03 | 30 |
GO:00313493 | Breast | Precancer | positive regulation of defense response | 33/1080 | 278/18723 | 6.79e-05 | 1.36e-03 | 33 |
GO:00026856 | Breast | Precancer | regulation of leukocyte migration | 27/1080 | 210/18723 | 7.93e-05 | 1.54e-03 | 27 |
GO:00508637 | Breast | Precancer | regulation of T cell activation | 37/1080 | 329/18723 | 8.04e-05 | 1.56e-03 | 37 |
GO:00224098 | Breast | Precancer | positive regulation of cell-cell adhesion | 33/1080 | 284/18723 | 1.03e-04 | 1.89e-03 | 33 |
GO:00071597 | Breast | Precancer | leukocyte cell-cell adhesion | 40/1080 | 371/18723 | 1.07e-04 | 1.94e-03 | 40 |
GO:00329709 | Breast | Precancer | regulation of actin filament-based process | 42/1080 | 397/18723 | 1.11e-04 | 2.01e-03 | 42 |
GO:00514959 | Breast | Precancer | positive regulation of cytoskeleton organization | 28/1080 | 226/18723 | 1.13e-04 | 2.04e-03 | 28 |
GO:00224079 | Breast | Precancer | regulation of cell-cell adhesion | 45/1080 | 448/18723 | 2.12e-04 | 3.30e-03 | 45 |
GO:19030377 | Breast | Precancer | regulation of leukocyte cell-cell adhesion | 36/1080 | 336/18723 | 2.61e-04 | 3.84e-03 | 36 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa045124 | Cervix | HSIL_HPV | ECM-receptor interaction | 12/459 | 89/8465 | 2.95e-03 | 1.88e-02 | 1.52e-02 | 12 |
hsa0451211 | Cervix | HSIL_HPV | ECM-receptor interaction | 12/459 | 89/8465 | 2.95e-03 | 1.88e-02 | 1.52e-02 | 12 |
hsa045125 | Prostate | BPH | ECM-receptor interaction | 28/1718 | 89/8465 | 8.33e-03 | 2.64e-02 | 1.64e-02 | 28 |
hsa0451212 | Prostate | BPH | ECM-receptor interaction | 28/1718 | 89/8465 | 8.33e-03 | 2.64e-02 | 1.64e-02 | 28 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
THBS1 | CD47 | THBS1_CD47 | THBS | Breast | ADJ |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | ADJ |
THBS1 | CD47 | THBS1_CD47 | THBS | Breast | DCIS |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | DCIS |
THBS3 | CD47 | THBS3_CD47 | THBS | Breast | DCIS |
THBS1 | CD47 | THBS1_CD47 | THBS | Breast | Healthy |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | Healthy |
THBS1 | CD47 | THBS1_CD47 | THBS | Breast | IDC |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | IDC |
COMP | CD47 | COMP_CD47 | THBS | Breast | IDC |
THBS1 | CD47 | THBS1_CD47 | THBS | Breast | Precancer |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | Precancer |
THBS1 | CD47 | THBS1_CD47 | THBS | Cervix | ADJ |
THBS2 | CD47 | THBS2_CD47 | THBS | Cervix | ADJ |
THBS1 | CD47 | THBS1_CD47 | THBS | Cervix | CC |
THBS2 | CD47 | THBS2_CD47 | THBS | Cervix | CC |
THBS1 | CD47 | THBS1_CD47 | THBS | Cervix | Healthy |
THBS2 | CD47 | THBS2_CD47 | THBS | Cervix | Healthy |
THBS1 | CD47 | THBS1_CD47 | THBS | Cervix | Precancer |
THBS2 | CD47 | THBS2_CD47 | THBS | Cervix | Precancer |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CD47 | SNV | Missense_Mutation | c.352N>C | p.Glu118Gln | p.E118Q | Q08722 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CD47 | SNV | Missense_Mutation | c.640N>C | p.Val214Leu | p.V214L | Q08722 | protein_coding | deleterious(0) | possibly_damaging(0.813) | TCGA-D8-A13Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
CD47 | SNV | Missense_Mutation | novel | c.922N>A | p.Glu308Lys | p.E308K | Q08722 | protein_coding | deleterious(0.03) | probably_damaging(0.991) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
CD47 | SNV | Missense_Mutation | novel | c.459N>G | p.Ile153Met | p.I153M | Q08722 | protein_coding | deleterious(0) | possibly_damaging(0.77) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CD47 | SNV | Missense_Mutation | c.643A>T | p.Thr215Ser | p.T215S | Q08722 | protein_coding | deleterious(0) | benign(0.296) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CD47 | SNV | Missense_Mutation | c.942N>C | p.Lys314Asn | p.K314N | Q08722 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CD47 | SNV | Missense_Mutation | novel | c.71N>C | p.Lys24Thr | p.K24T | Q08722 | protein_coding | tolerated(0.59) | benign(0.021) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CD47 | SNV | Missense_Mutation | c.478T>C | p.Phe160Leu | p.F160L | Q08722 | protein_coding | tolerated(0.64) | benign(0.272) | TCGA-CL-4957-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
CD47 | SNV | Missense_Mutation | novel | c.692N>T | p.Ala231Val | p.A231V | Q08722 | protein_coding | tolerated(0.71) | benign(0.185) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CD47 | SNV | Missense_Mutation | rs754405285 | c.785N>T | p.Ala262Val | p.A262V | Q08722 | protein_coding | tolerated(0.07) | benign(0.012) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
961 | CD47 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | ABT-510 | ABT-510 | ||
961 | CD47 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | ALX148 | ALX-148 | ||
961 | CD47 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | TTI-621 | |||
961 | CD47 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | CC-90002 | |||
961 | CD47 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | Hu5F9-G4 | MAGROLIMAB |
Page: 1 |