|
Gene: CCSER1 |
Gene summary for CCSER1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CCSER1 | Gene ID | 401145 |
Gene name | coiled-coil serine rich protein 1 | |
Gene Alias | FAM190A | |
Cytomap | 4q22.1 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q9C0I3 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
401145 | CCSER1 | A018-E-020 | Human | Colorectum | FAP | 6.84e-21 | -4.48e-01 | -0.2034 |
401145 | CCSER1 | F034 | Human | Colorectum | FAP | 2.66e-26 | -4.33e-01 | -0.0665 |
401145 | CCSER1 | F072B | Human | Colorectum | FAP | 4.10e-43 | 5.47e-01 | 0.257 |
401145 | CCSER1 | CRC-3-11773 | Human | Colorectum | CRC | 5.68e-08 | 2.94e-01 | 0.2564 |
401145 | CCSER1 | AEH-subject1 | Human | Endometrium | AEH | 1.74e-51 | 9.43e-01 | -0.3059 |
401145 | CCSER1 | AEH-subject2 | Human | Endometrium | AEH | 1.11e-46 | 1.05e+00 | -0.2525 |
401145 | CCSER1 | AEH-subject3 | Human | Endometrium | AEH | 2.04e-40 | 8.44e-01 | -0.2576 |
401145 | CCSER1 | AEH-subject4 | Human | Endometrium | AEH | 6.09e-34 | 8.85e-01 | -0.2657 |
401145 | CCSER1 | AEH-subject5 | Human | Endometrium | AEH | 5.65e-57 | 1.10e+00 | -0.2953 |
401145 | CCSER1 | EEC-subject1 | Human | Endometrium | EEC | 2.17e-42 | 8.81e-01 | -0.2682 |
401145 | CCSER1 | EEC-subject2 | Human | Endometrium | EEC | 2.16e-23 | 5.79e-01 | -0.2607 |
401145 | CCSER1 | EEC-subject3 | Human | Endometrium | EEC | 4.35e-24 | 7.57e-01 | -0.2525 |
401145 | CCSER1 | EEC-subject4 | Human | Endometrium | EEC | 3.41e-23 | 7.35e-01 | -0.2571 |
401145 | CCSER1 | EEC-subject5 | Human | Endometrium | EEC | 2.78e-32 | 7.84e-01 | -0.249 |
401145 | CCSER1 | TD9 | Human | Lung | IAC | 4.70e-13 | 1.21e+00 | 0.088 |
401145 | CCSER1 | RNA-P10T1-P10T1-1 | Human | Lung | AIS | 1.16e-02 | 1.09e+00 | -0.0764 |
401145 | CCSER1 | RNA-P10T2-P10T2-1 | Human | Lung | AAH | 7.31e-03 | 6.16e-01 | -0.1271 |
401145 | CCSER1 | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 4.97e-07 | 9.35e-01 | -0.1406 |
401145 | CCSER1 | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 1.97e-09 | 1.00e+00 | -0.1408 |
401145 | CCSER1 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 3.02e-07 | 9.16e-01 | -0.138 |
Page: 1 2 3 4 5 6 7 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCSER1 | SNV | Missense_Mutation | novel | c.2324N>A | p.Thr775Lys | p.T775K | Q9C0I3 | protein_coding | deleterious_low_confidence(0.05) | benign(0.075) | TCGA-A8-A09V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
CCSER1 | SNV | Missense_Mutation | c.1917N>C | p.Lys639Asn | p.K639N | Q9C0I3 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-AQ-A0Y5-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | SD | |
CCSER1 | SNV | Missense_Mutation | novel | c.1312N>G | p.Asn438Asp | p.N438D | Q9C0I3 | protein_coding | deleterious(0) | possibly_damaging(0.461) | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD |
CCSER1 | SNV | Missense_Mutation | rs776917983 | c.2587N>G | p.Phe863Val | p.F863V | Q9C0I3 | protein_coding | deleterious_low_confidence(0.02) | benign(0.088) | TCGA-AR-A1AP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
CCSER1 | SNV | Missense_Mutation | c.1853N>G | p.Ser618Cys | p.S618C | Q9C0I3 | protein_coding | deleterious(0.01) | possibly_damaging(0.76) | TCGA-BH-A0BA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD | |
CCSER1 | SNV | Missense_Mutation | rs776917983 | c.2587N>G | p.Phe863Val | p.F863V | Q9C0I3 | protein_coding | deleterious_low_confidence(0.02) | benign(0.088) | TCGA-D8-A1X6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
CCSER1 | insertion | Nonsense_Mutation | novel | c.851_852insAAGTTTAACTTGTTTATAACCCTATGTTATA | p.Cys284Ter | p.C284* | Q9C0I3 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CCSER1 | insertion | In_Frame_Ins | novel | c.1313_1314insGGT | p.Asn438delinsLysVal | p.N438delinsKV | Q9C0I3 | protein_coding | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | ||
CCSER1 | SNV | Missense_Mutation | rs774767718 | c.191G>A | p.Arg64His | p.R64H | Q9C0I3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CCSER1 | SNV | Missense_Mutation | c.1733C>A | p.Ser578Tyr | p.S578Y | Q9C0I3 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-VS-A94W-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |