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Gene: CCNC |
Gene summary for CCNC |
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Gene information | Species | Human | Gene symbol | CCNC | Gene ID | 892 |
Gene name | cyclin C | |
Gene Alias | CycC | |
Cytomap | 6q16.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P24863 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
892 | CCNC | P48T-E | Human | Esophagus | ESCC | 1.96e-12 | 3.55e-01 | 0.0959 |
892 | CCNC | P49T-E | Human | Esophagus | ESCC | 1.88e-11 | 1.36e+00 | 0.1768 |
892 | CCNC | P52T-E | Human | Esophagus | ESCC | 4.41e-32 | 1.12e+00 | 0.1555 |
892 | CCNC | P54T-E | Human | Esophagus | ESCC | 2.47e-13 | 3.40e-01 | 0.0975 |
892 | CCNC | P56T-E | Human | Esophagus | ESCC | 5.40e-07 | 1.40e+00 | 0.1613 |
892 | CCNC | P57T-E | Human | Esophagus | ESCC | 8.07e-20 | 3.98e-01 | 0.0926 |
892 | CCNC | P61T-E | Human | Esophagus | ESCC | 4.86e-16 | 4.46e-01 | 0.099 |
892 | CCNC | P62T-E | Human | Esophagus | ESCC | 1.68e-59 | 1.10e+00 | 0.1302 |
892 | CCNC | P65T-E | Human | Esophagus | ESCC | 9.00e-14 | 2.10e-01 | 0.0978 |
892 | CCNC | P74T-E | Human | Esophagus | ESCC | 8.76e-31 | 1.05e+00 | 0.1479 |
892 | CCNC | P75T-E | Human | Esophagus | ESCC | 6.31e-38 | 8.85e-01 | 0.1125 |
892 | CCNC | P76T-E | Human | Esophagus | ESCC | 2.33e-41 | 8.77e-01 | 0.1207 |
892 | CCNC | P79T-E | Human | Esophagus | ESCC | 8.19e-31 | 8.08e-01 | 0.1154 |
892 | CCNC | P80T-E | Human | Esophagus | ESCC | 4.48e-49 | 1.36e+00 | 0.155 |
892 | CCNC | P82T-E | Human | Esophagus | ESCC | 9.58e-17 | 1.03e+00 | 0.1072 |
892 | CCNC | P83T-E | Human | Esophagus | ESCC | 6.23e-35 | 1.23e+00 | 0.1738 |
892 | CCNC | P84T-E | Human | Esophagus | ESCC | 2.55e-13 | 6.80e-01 | 0.0933 |
892 | CCNC | P89T-E | Human | Esophagus | ESCC | 1.02e-25 | 1.72e+00 | 0.1752 |
892 | CCNC | P91T-E | Human | Esophagus | ESCC | 3.26e-16 | 1.96e+00 | 0.1828 |
892 | CCNC | P104T-E | Human | Esophagus | ESCC | 5.74e-05 | 7.40e-01 | 0.0931 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCNC | SNV | Missense_Mutation | c.720N>C | p.Gln240His | p.Q240H | P24863 | protein_coding | deleterious(0) | benign(0.066) | TCGA-A8-A085-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
CCNC | deletion | Frame_Shift_Del | novel | c.288delN | p.Val97Ter | p.V97* | P24863 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
CCNC | SNV | Missense_Mutation | novel | c.335N>A | p.Ala112Asp | p.A112D | P24863 | protein_coding | deleterious(0) | possibly_damaging(0.84) | TCGA-VS-A8EL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CCNC | SNV | Missense_Mutation | novel | c.334N>A | p.Ala112Thr | p.A112T | P24863 | protein_coding | tolerated(0.36) | benign(0.006) | TCGA-VS-A8EL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CCNC | SNV | Missense_Mutation | rs755107219 | c.74N>A | p.Arg25His | p.R25H | P24863 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCNC | SNV | Missense_Mutation | novel | c.458N>G | p.Tyr153Cys | p.Y153C | P24863 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CCNC | SNV | Missense_Mutation | c.268N>C | p.Cys90Arg | p.C90R | P24863 | protein_coding | deleterious(0) | possibly_damaging(0.576) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CCNC | SNV | Missense_Mutation | rs755107219 | c.74N>A | p.Arg25His | p.R25H | P24863 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-AH-6644-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
CCNC | SNV | Missense_Mutation | rs755107219 | c.74G>A | p.Arg25His | p.R25H | P24863 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CCNC | SNV | Missense_Mutation | rs755107219 | c.74G>A | p.Arg25His | p.R25H | P24863 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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