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Gene: CCDC51 |
Gene summary for CCDC51 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CCDC51 | Gene ID | 79714 |
| Gene name | coiled-coil domain containing 51 | |
| Gene Alias | MITOK | |
| Cytomap | 3p21.31 | |
| Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q96ER9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 79714 | CCDC51 | P74T-E | Human | Esophagus | ESCC | 7.15e-47 | 1.22e+00 | 0.1479 |
| 79714 | CCDC51 | P75T-E | Human | Esophagus | ESCC | 1.50e-13 | 3.07e-01 | 0.1125 |
| 79714 | CCDC51 | P76T-E | Human | Esophagus | ESCC | 4.19e-11 | 1.84e-01 | 0.1207 |
| 79714 | CCDC51 | P79T-E | Human | Esophagus | ESCC | 8.78e-07 | 1.70e-01 | 0.1154 |
| 79714 | CCDC51 | P80T-E | Human | Esophagus | ESCC | 5.31e-13 | 3.90e-01 | 0.155 |
| 79714 | CCDC51 | P82T-E | Human | Esophagus | ESCC | 1.45e-03 | 2.72e-01 | 0.1072 |
| 79714 | CCDC51 | P83T-E | Human | Esophagus | ESCC | 1.40e-30 | 6.94e-01 | 0.1738 |
| 79714 | CCDC51 | P84T-E | Human | Esophagus | ESCC | 4.41e-03 | 2.84e-01 | 0.0933 |
| 79714 | CCDC51 | P89T-E | Human | Esophagus | ESCC | 9.87e-08 | 6.35e-01 | 0.1752 |
| 79714 | CCDC51 | P91T-E | Human | Esophagus | ESCC | 7.15e-07 | 4.87e-01 | 0.1828 |
| 79714 | CCDC51 | P107T-E | Human | Esophagus | ESCC | 1.07e-27 | 6.31e-01 | 0.171 |
| 79714 | CCDC51 | P127T-E | Human | Esophagus | ESCC | 4.70e-02 | 4.78e-02 | 0.0826 |
| 79714 | CCDC51 | P128T-E | Human | Esophagus | ESCC | 1.47e-13 | 4.22e-01 | 0.1241 |
| 79714 | CCDC51 | P130T-E | Human | Esophagus | ESCC | 4.41e-40 | 8.69e-01 | 0.1676 |
| 79714 | CCDC51 | HCC1_Meng | Human | Liver | HCC | 3.41e-41 | 1.26e-01 | 0.0246 |
| 79714 | CCDC51 | HCC2_Meng | Human | Liver | HCC | 2.63e-02 | 3.00e-03 | 0.0107 |
| 79714 | CCDC51 | HCC5 | Human | Liver | HCC | 4.67e-03 | 4.84e-01 | 0.4932 |
| 79714 | CCDC51 | S014 | Human | Liver | HCC | 1.39e-18 | 5.40e-01 | 0.2254 |
| 79714 | CCDC51 | S015 | Human | Liver | HCC | 4.93e-14 | 5.96e-01 | 0.2375 |
| 79714 | CCDC51 | S016 | Human | Liver | HCC | 9.97e-17 | 5.32e-01 | 0.2243 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CCDC51 | SNV | Missense_Mutation | c.1195G>A | p.Ala399Thr | p.A399T | Q96ER9 | protein_coding | tolerated(0.13) | possibly_damaging(0.465) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| CCDC51 | SNV | Missense_Mutation | c.603N>T | p.Lys201Asn | p.K201N | Q96ER9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| CCDC51 | SNV | Missense_Mutation | c.755C>T | p.Ala252Val | p.A252V | Q96ER9 | protein_coding | tolerated(0.09) | probably_damaging(0.958) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| CCDC51 | SNV | Missense_Mutation | c.84N>T | p.Arg28Ser | p.R28S | Q96ER9 | protein_coding | tolerated_low_confidence(0.38) | benign(0.017) | TCGA-F4-6807-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | CR | |
| CCDC51 | SNV | Missense_Mutation | c.646N>A | p.Val216Met | p.V216M | Q96ER9 | protein_coding | deleterious(0) | possibly_damaging(0.892) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| CCDC51 | SNV | Missense_Mutation | c.793N>A | p.Leu265Ile | p.L265I | Q96ER9 | protein_coding | tolerated(0.2) | benign(0.203) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| CCDC51 | SNV | Missense_Mutation | novel | c.596N>T | p.Arg199Met | p.R199M | Q96ER9 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| CCDC51 | SNV | Missense_Mutation | novel | c.905N>T | p.Ala302Val | p.A302V | Q96ER9 | protein_coding | deleterious(0.03) | benign(0.178) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| CCDC51 | SNV | Missense_Mutation | novel | c.878N>G | p.Asp293Gly | p.D293G | Q96ER9 | protein_coding | tolerated(0.37) | benign(0) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| CCDC51 | SNV | Missense_Mutation | novel | c.473N>C | p.Leu158Pro | p.L158P | Q96ER9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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