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Gene: CBX8 |
Gene summary for CBX8 |
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Gene information | Species | Human | Gene symbol | CBX8 | Gene ID | 57332 |
Gene name | chromobox 8 | |
Gene Alias | PC3 | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9HC52 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57332 | CBX8 | P130T-E | Human | Esophagus | ESCC | 1.70e-28 | 5.32e-01 | 0.1676 |
57332 | CBX8 | HCC1_Meng | Human | Liver | HCC | 1.40e-22 | 3.23e-02 | 0.0246 |
57332 | CBX8 | S014 | Human | Liver | HCC | 1.33e-27 | 7.13e-01 | 0.2254 |
57332 | CBX8 | S015 | Human | Liver | HCC | 8.32e-13 | 5.14e-01 | 0.2375 |
57332 | CBX8 | S016 | Human | Liver | HCC | 1.12e-25 | 6.75e-01 | 0.2243 |
57332 | CBX8 | S027 | Human | Liver | HCC | 7.06e-10 | 6.02e-01 | 0.2446 |
57332 | CBX8 | S028 | Human | Liver | HCC | 3.58e-15 | 4.25e-01 | 0.2503 |
57332 | CBX8 | S029 | Human | Liver | HCC | 1.44e-15 | 5.12e-01 | 0.2581 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:0062197111 | Esophagus | ESCC | cellular response to chemical stress | 234/8552 | 337/18723 | 5.37e-19 | 5.97e-17 | 234 |
GO:0034599111 | Esophagus | ESCC | cellular response to oxidative stress | 197/8552 | 288/18723 | 3.76e-15 | 2.15e-13 | 197 |
GO:005105215 | Esophagus | ESCC | regulation of DNA metabolic process | 232/8552 | 359/18723 | 2.40e-13 | 1.13e-11 | 232 |
GO:005105417 | Esophagus | ESCC | positive regulation of DNA metabolic process | 139/8552 | 201/18723 | 1.20e-11 | 4.33e-10 | 139 |
GO:0000302111 | Esophagus | ESCC | response to reactive oxygen species | 150/8552 | 222/18723 | 3.06e-11 | 1.02e-09 | 150 |
GO:2001020110 | Esophagus | ESCC | regulation of response to DNA damage stimulus | 145/8552 | 219/18723 | 5.97e-10 | 1.50e-08 | 145 |
GO:0042542111 | Esophagus | ESCC | response to hydrogen peroxide | 102/8552 | 146/18723 | 2.64e-09 | 5.81e-08 | 102 |
GO:001657414 | Esophagus | ESCC | histone ubiquitination | 40/8552 | 47/18723 | 2.40e-08 | 4.55e-07 | 40 |
GO:003461420 | Esophagus | ESCC | cellular response to reactive oxygen species | 103/8552 | 155/18723 | 1.34e-07 | 2.17e-06 | 103 |
GO:00703018 | Esophagus | ESCC | cellular response to hydrogen peroxide | 68/8552 | 98/18723 | 1.70e-06 | 2.03e-05 | 68 |
GO:20010228 | Esophagus | ESCC | positive regulation of response to DNA damage stimulus | 69/8552 | 105/18723 | 2.66e-05 | 2.22e-04 | 69 |
GO:00062826 | Esophagus | ESCC | regulation of DNA repair | 82/8552 | 130/18723 | 4.65e-05 | 3.66e-04 | 82 |
GO:00457395 | Esophagus | ESCC | positive regulation of DNA repair | 49/8552 | 73/18723 | 1.74e-04 | 1.14e-03 | 49 |
GO:00329631 | Esophagus | ESCC | collagen metabolic process | 62/8552 | 104/18723 | 2.90e-03 | 1.22e-02 | 62 |
GO:000697922 | Liver | HCC | response to oxidative stress | 281/7958 | 446/18723 | 9.75e-19 | 1.24e-16 | 281 |
GO:001657021 | Liver | HCC | histone modification | 283/7958 | 463/18723 | 2.68e-16 | 2.33e-14 | 283 |
GO:006219722 | Liver | HCC | cellular response to chemical stress | 216/7958 | 337/18723 | 6.86e-16 | 5.44e-14 | 216 |
GO:003459922 | Liver | HCC | cellular response to oxidative stress | 183/7958 | 288/18723 | 3.65e-13 | 1.93e-11 | 183 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CBX8 | SNV | Missense_Mutation | novel | c.248C>T | p.Ala83Val | p.A83V | Q9HC52 | protein_coding | deleterious(0) | benign(0.228) | TCGA-A8-A07G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
CBX8 | SNV | Missense_Mutation | novel | c.1161N>T | p.Glu387Asp | p.E387D | Q9HC52 | protein_coding | tolerated(0.24) | possibly_damaging(0.675) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CBX8 | SNV | Missense_Mutation | novel | c.944N>A | p.Ser315Asn | p.S315N | Q9HC52 | protein_coding | tolerated(0.45) | benign(0.007) | TCGA-BH-A0DH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
CBX8 | SNV | Missense_Mutation | c.1155N>A | p.Phe385Leu | p.F385L | Q9HC52 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-C8-A12M-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CBX8 | SNV | Missense_Mutation | c.146N>C | p.Leu49Pro | p.L49P | Q9HC52 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CBX8 | SNV | Missense_Mutation | c.986N>A | p.Gly329Glu | p.G329E | Q9HC52 | protein_coding | tolerated(0.18) | probably_damaging(0.998) | TCGA-E2-A15H-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | herceptin | SD | |
CBX8 | SNV | Missense_Mutation | c.647N>A | p.Gly216Asp | p.G216D | Q9HC52 | protein_coding | tolerated(0.42) | possibly_damaging(0.69) | TCGA-E2-A15H-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | herceptin | SD | |
CBX8 | SNV | Missense_Mutation | novel | c.802T>C | p.Ser268Pro | p.S268P | Q9HC52 | protein_coding | tolerated(0.38) | benign(0) | TCGA-A6-2678-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
CBX8 | SNV | Missense_Mutation | c.214N>T | p.Arg72Cys | p.R72C | Q9HC52 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CBX8 | SNV | Missense_Mutation | c.215N>A | p.Arg72His | p.R72H | Q9HC52 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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