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Gene: CAVIN1 |
Gene summary for CAVIN1 |
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Gene information | Species | Human | Gene symbol | CAVIN1 | Gene ID | 284119 |
Gene name | caveolae associated protein 1 | |
Gene Alias | CAVIN | |
Cytomap | 17q21.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6NZI2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284119 | CAVIN1 | LZE4T | Human | Esophagus | ESCC | 9.53e-29 | 7.23e-01 | 0.0811 |
284119 | CAVIN1 | LZE7T | Human | Esophagus | ESCC | 3.90e-02 | 1.77e-01 | 0.0667 |
284119 | CAVIN1 | LZE8T | Human | Esophagus | ESCC | 4.02e-05 | 1.89e-01 | 0.067 |
284119 | CAVIN1 | LZE22D1 | Human | Esophagus | HGIN | 1.24e-04 | 3.09e-01 | 0.0595 |
284119 | CAVIN1 | LZE22T | Human | Esophagus | ESCC | 1.00e-09 | 8.17e-01 | 0.068 |
284119 | CAVIN1 | LZE24T | Human | Esophagus | ESCC | 2.14e-21 | 7.23e-01 | 0.0596 |
284119 | CAVIN1 | LZE21T | Human | Esophagus | ESCC | 2.27e-11 | 9.43e-01 | 0.0655 |
284119 | CAVIN1 | LZE6T | Human | Esophagus | ESCC | 1.87e-12 | 5.54e-01 | 0.0845 |
284119 | CAVIN1 | S015 | Human | Liver | HCC | 1.34e-02 | 2.96e-01 | 0.2375 |
284119 | CAVIN1 | S027 | Human | Liver | HCC | 2.19e-25 | 1.37e+00 | 0.2446 |
284119 | CAVIN1 | S028 | Human | Liver | HCC | 1.30e-30 | 1.03e+00 | 0.2503 |
284119 | CAVIN1 | S029 | Human | Liver | HCC | 5.68e-34 | 1.11e+00 | 0.2581 |
284119 | CAVIN1 | GSM5252128_BPH327PrGF_Via | Human | Prostate | BPH | 1.32e-05 | -1.79e-01 | -0.1688 |
284119 | CAVIN1 | GSM5252130_BPH340PrGF_Via | Human | Prostate | BPH | 1.64e-10 | 6.94e-01 | -0.1972 |
284119 | CAVIN1 | GSM5252131_BPH340PrSF_Via | Human | Prostate | BPH | 3.48e-07 | 3.37e-01 | -0.2126 |
284119 | CAVIN1 | GSM5252132_BPH389PrGF | Human | Prostate | BPH | 3.24e-02 | 7.58e-01 | -0.2247 |
284119 | CAVIN1 | GSM5252133_BPH389PrSF | Human | Prostate | BPH | 3.29e-08 | 4.54e-01 | -0.2027 |
284119 | CAVIN1 | GSM5252135_BPH511PrPUr_Fcol_3GEX | Human | Prostate | BPH | 2.29e-05 | 1.60e-01 | -0.1833 |
284119 | CAVIN1 | GSM5252136_BPH556PrGA1_Fcol | Human | Prostate | BPH | 5.27e-03 | 5.70e-02 | -0.23 |
284119 | CAVIN1 | GSM5252137_BPH556PrGA2_Fcol | Human | Prostate | BPH | 1.08e-04 | -2.81e-02 | -0.23 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00716926 | Breast | Precancer | protein localization to extracellular region | 34/1080 | 368/18723 | 4.65e-03 | 3.58e-02 | 34 |
GO:00093067 | Breast | Precancer | protein secretion | 33/1080 | 359/18723 | 5.65e-03 | 4.08e-02 | 33 |
GO:00355927 | Breast | Precancer | establishment of protein localization to extracellular region | 33/1080 | 360/18723 | 5.89e-03 | 4.21e-02 | 33 |
GO:007169212 | Breast | IDC | protein localization to extracellular region | 42/1434 | 368/18723 | 6.13e-03 | 4.38e-02 | 42 |
GO:000930613 | Breast | IDC | protein secretion | 41/1434 | 359/18723 | 6.64e-03 | 4.63e-02 | 41 |
GO:003559213 | Breast | IDC | establishment of protein localization to extracellular region | 41/1434 | 360/18723 | 6.96e-03 | 4.81e-02 | 41 |
GO:007169222 | Breast | DCIS | protein localization to extracellular region | 41/1390 | 368/18723 | 6.01e-03 | 4.29e-02 | 41 |
GO:000930622 | Breast | DCIS | protein secretion | 40/1390 | 359/18723 | 6.59e-03 | 4.61e-02 | 40 |
GO:003559222 | Breast | DCIS | establishment of protein localization to extracellular region | 40/1390 | 360/18723 | 6.90e-03 | 4.77e-02 | 40 |
GO:00716927 | Endometrium | AEH | protein localization to extracellular region | 58/2100 | 368/18723 | 4.72e-03 | 3.00e-02 | 58 |
GO:00093068 | Endometrium | AEH | protein secretion | 56/2100 | 359/18723 | 6.71e-03 | 3.94e-02 | 56 |
GO:00355928 | Endometrium | AEH | establishment of protein localization to extracellular region | 56/2100 | 360/18723 | 7.10e-03 | 4.09e-02 | 56 |
GO:007169213 | Endometrium | EEC | protein localization to extracellular region | 59/2168 | 368/18723 | 5.98e-03 | 3.56e-02 | 59 |
GO:000930614 | Endometrium | EEC | protein secretion | 57/2168 | 359/18723 | 8.30e-03 | 4.57e-02 | 57 |
GO:003559214 | Endometrium | EEC | establishment of protein localization to extracellular region | 57/2168 | 360/18723 | 8.78e-03 | 4.74e-02 | 57 |
GO:00063523 | Esophagus | HGIN | DNA-templated transcription, initiation | 30/2587 | 130/18723 | 2.86e-03 | 2.79e-02 | 30 |
GO:00987812 | Esophagus | ESCC | ncRNA transcription | 45/8552 | 56/18723 | 1.05e-07 | 1.72e-06 | 45 |
GO:000635211 | Esophagus | ESCC | DNA-templated transcription, initiation | 86/8552 | 130/18723 | 1.88e-06 | 2.19e-05 | 86 |
GO:00063602 | Esophagus | ESCC | transcription by RNA polymerase I | 42/8552 | 55/18723 | 3.41e-06 | 3.78e-05 | 42 |
GO:00093032 | Esophagus | ESCC | rRNA transcription | 28/8552 | 34/18723 | 1.21e-05 | 1.12e-04 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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