![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CAPN5 |
Gene summary for CAPN5 |
![]() |
Gene information | Species | Human | Gene symbol | CAPN5 | Gene ID | 726 |
Gene name | calpain 5 | |
Gene Alias | ADNIV | |
Cytomap | 11q13.5 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | A0A140VKH4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
726 | CAPN5 | P82T-E | Human | Esophagus | ESCC | 9.26e-12 | 7.62e-01 | 0.1072 |
726 | CAPN5 | P94T-E | Human | Esophagus | ESCC | 5.71e-05 | 7.78e-01 | 0.0879 |
726 | CAPN5 | P104T-E | Human | Esophagus | ESCC | 6.91e-11 | 6.68e-01 | 0.0931 |
726 | CAPN5 | P128T-E | Human | Esophagus | ESCC | 1.02e-27 | 9.57e-01 | 0.1241 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAPN5 | SNV | Missense_Mutation | rs369845664 | c.1177N>A | p.Glu393Lys | p.E393K | O15484 | protein_coding | deleterious(0.01) | benign(0.059) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAPN5 | SNV | Missense_Mutation | c.1029N>G | p.Ile343Met | p.I343M | O15484 | protein_coding | tolerated(0.18) | benign(0.122) | TCGA-AR-A1AP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | |
CAPN5 | insertion | Frame_Shift_Ins | novel | c.694_695insCCGCTCTTTTTTTTTT | p.Ile232ThrfsTer13 | p.I232Tfs*13 | O15484 | protein_coding | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CAPN5 | insertion | Frame_Shift_Ins | novel | c.1758_1759insACTCCAAGGTCCCT | p.Leu587ThrfsTer6 | p.L587Tfs*6 | O15484 | protein_coding | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CAPN5 | SNV | Missense_Mutation | rs369500943 | c.961N>A | p.Gly321Ser | p.G321S | O15484 | protein_coding | deleterious(0) | probably_damaging(0.932) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CAPN5 | SNV | Missense_Mutation | rs372682170 | c.847N>T | p.Arg283Cys | p.R283C | O15484 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VS-A8EK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
CAPN5 | SNV | Missense_Mutation | novel | c.858N>T | p.Trp286Cys | p.W286C | O15484 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
CAPN5 | SNV | Missense_Mutation | rs370528920 | c.1238C>T | p.Thr413Met | p.T413M | O15484 | protein_coding | tolerated(0.22) | possibly_damaging(0.846) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAPN5 | SNV | Missense_Mutation | c.1345N>A | p.Ser449Thr | p.S449T | O15484 | protein_coding | tolerated(0.07) | probably_damaging(0.998) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CAPN5 | SNV | Missense_Mutation | rs369845664 | c.1177G>A | p.Glu393Lys | p.E393K | O15484 | protein_coding | deleterious(0.01) | benign(0.059) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |