|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: CAD |
Gene summary for CAD |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CAD | Gene ID | 790 |
| Gene name | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | |
| Gene Alias | CDG1Z | |
| Cytomap | 2p23.3 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | F8VPD4 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 790 | CAD | P75T-E | Human | Esophagus | ESCC | 2.28e-05 | 1.02e-01 | 0.1125 |
| 790 | CAD | P76T-E | Human | Esophagus | ESCC | 1.19e-07 | 2.02e-01 | 0.1207 |
| 790 | CAD | P79T-E | Human | Esophagus | ESCC | 1.53e-11 | 2.24e-01 | 0.1154 |
| 790 | CAD | P80T-E | Human | Esophagus | ESCC | 2.10e-17 | 4.76e-01 | 0.155 |
| 790 | CAD | P82T-E | Human | Esophagus | ESCC | 1.68e-07 | 3.20e-01 | 0.1072 |
| 790 | CAD | P83T-E | Human | Esophagus | ESCC | 3.14e-12 | 4.96e-01 | 0.1738 |
| 790 | CAD | P89T-E | Human | Esophagus | ESCC | 4.03e-11 | 4.27e-01 | 0.1752 |
| 790 | CAD | P91T-E | Human | Esophagus | ESCC | 2.24e-06 | 7.15e-01 | 0.1828 |
| 790 | CAD | P107T-E | Human | Esophagus | ESCC | 1.01e-24 | 5.75e-01 | 0.171 |
| 790 | CAD | P127T-E | Human | Esophagus | ESCC | 7.68e-07 | 7.94e-02 | 0.0826 |
| 790 | CAD | P128T-E | Human | Esophagus | ESCC | 2.11e-20 | 6.28e-01 | 0.1241 |
| 790 | CAD | P130T-E | Human | Esophagus | ESCC | 6.45e-28 | 6.19e-01 | 0.1676 |
| 790 | CAD | HCC1_Meng | Human | Liver | HCC | 5.50e-64 | 1.17e-01 | 0.0246 |
| 790 | CAD | HCC1 | Human | Liver | HCC | 2.81e-05 | 4.57e+00 | 0.5336 |
| 790 | CAD | HCC2 | Human | Liver | HCC | 7.67e-09 | 3.03e+00 | 0.5341 |
| 790 | CAD | S014 | Human | Liver | HCC | 1.43e-24 | 9.16e-01 | 0.2254 |
| 790 | CAD | S015 | Human | Liver | HCC | 2.42e-20 | 8.98e-01 | 0.2375 |
| 790 | CAD | S016 | Human | Liver | HCC | 2.88e-25 | 8.68e-01 | 0.2243 |
| 790 | CAD | S027 | Human | Liver | HCC | 7.11e-05 | 4.90e-01 | 0.2446 |
| 790 | CAD | S028 | Human | Liver | HCC | 1.04e-22 | 7.42e-01 | 0.2503 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00060918 | Breast | Precancer | generation of precursor metabolites and energy | 94/1080 | 490/18723 | 1.54e-25 | 1.64e-22 | 94 |
| GO:00159808 | Breast | Precancer | energy derivation by oxidation of organic compounds | 70/1080 | 318/18723 | 8.33e-23 | 6.37e-20 | 70 |
| GO:00092667 | Breast | Precancer | response to temperature stimulus | 27/1080 | 178/18723 | 3.85e-06 | 1.21e-04 | 27 |
| GO:00192164 | Breast | Precancer | regulation of lipid metabolic process | 34/1080 | 331/18723 | 8.14e-04 | 9.55e-03 | 34 |
| GO:00463946 | Breast | Precancer | carboxylic acid biosynthetic process | 32/1080 | 314/18723 | 1.30e-03 | 1.38e-02 | 32 |
| GO:00723304 | Breast | Precancer | monocarboxylic acid biosynthetic process | 24/1080 | 214/18723 | 1.41e-03 | 1.48e-02 | 24 |
| GO:00160536 | Breast | Precancer | organic acid biosynthetic process | 32/1080 | 316/18723 | 1.44e-03 | 1.50e-02 | 32 |
| GO:00094097 | Breast | Precancer | response to cold | 9/1080 | 49/18723 | 1.74e-03 | 1.74e-02 | 9 |
| GO:00066335 | Breast | Precancer | fatty acid biosynthetic process | 19/1080 | 163/18723 | 2.74e-03 | 2.42e-02 | 19 |
| GO:00620126 | Breast | Precancer | regulation of small molecule metabolic process | 32/1080 | 334/18723 | 3.45e-03 | 2.87e-02 | 32 |
| GO:00423044 | Breast | Precancer | regulation of fatty acid biosynthetic process | 8/1080 | 49/18723 | 6.53e-03 | 4.51e-02 | 8 |
| GO:000609113 | Breast | IDC | generation of precursor metabolites and energy | 103/1434 | 490/18723 | 1.53e-21 | 1.74e-18 | 103 |
| GO:001598013 | Breast | IDC | energy derivation by oxidation of organic compounds | 73/1434 | 318/18723 | 8.70e-18 | 3.80e-15 | 73 |
| GO:000926612 | Breast | IDC | response to temperature stimulus | 34/1434 | 178/18723 | 5.88e-07 | 2.83e-05 | 34 |
| GO:000940912 | Breast | IDC | response to cold | 13/1434 | 49/18723 | 5.70e-05 | 1.20e-03 | 13 |
| GO:001921612 | Breast | IDC | regulation of lipid metabolic process | 45/1434 | 331/18723 | 1.21e-04 | 2.24e-03 | 45 |
| GO:00192184 | Breast | IDC | regulation of steroid metabolic process | 18/1434 | 100/18723 | 5.40e-04 | 6.96e-03 | 18 |
| GO:00468904 | Breast | IDC | regulation of lipid biosynthetic process | 26/1434 | 171/18723 | 5.92e-04 | 7.50e-03 | 26 |
| GO:007233012 | Breast | IDC | monocarboxylic acid biosynthetic process | 29/1434 | 214/18723 | 1.91e-03 | 1.83e-02 | 29 |
| GO:001605313 | Breast | IDC | organic acid biosynthetic process | 39/1434 | 316/18723 | 2.13e-03 | 1.99e-02 | 39 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
| hsa002405 | Esophagus | ESCC | Pyrimidine metabolism | 41/4205 | 58/8465 | 9.14e-04 | 2.92e-03 | 1.49e-03 | 41 |
| hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
| hsa0024012 | Esophagus | ESCC | Pyrimidine metabolism | 41/4205 | 58/8465 | 9.14e-04 | 2.92e-03 | 1.49e-03 | 41 |
| hsa012402 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
| hsa002402 | Liver | HCC | Pyrimidine metabolism | 44/4020 | 58/8465 | 9.34e-06 | 7.11e-05 | 3.95e-05 | 44 |
| hsa012403 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
| hsa002403 | Liver | HCC | Pyrimidine metabolism | 44/4020 | 58/8465 | 9.34e-06 | 7.11e-05 | 3.95e-05 | 44 |
| hsa012404 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
| hsa0124011 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| CADM1 | CADM1 | CADM1_CADM1 | CADM | Breast | DCIS |
| CADM1 | CADM1 | CADM1_CADM1 | CADM | Breast | IDC |
| CADM1 | CADM1 | CADM1_CADM1 | CADM | Cervix | Precancer |
| CADM1 | CADM1 | CADM1_CADM1 | CADM | CRC | ADJ |
| CADM1 | CADM1 | CADM1_CADM1 | CADM | CRC | CRC |
| CADM1 | CADM1 | CADM1_CADM1 | CADM | CRC | FAP |
| CADM1 | CADM1 | CADM1_CADM1 | CADM | Endometrium | ADJ |
| CADM1 | CADM1 | CADM1_CADM1 | CADM | Endometrium | AEH |
| CADM1 | CADM1 | CADM1_CADM1 | CADM | Endometrium | EEC |
| CADM1 | CADM1 | CADM1_CADM1 | CADM | Endometrium | Healthy |
| CADM1 | CADM1 | CADM1_CADM1 | CADM | Esophagus | ADJ |
| CADM1 | CADM1 | CADM1_CADM1 | CADM | Esophagus | ESCC |
| CADM1 | CADM1 | CADM1_CADM1 | CADM | GC | ADJ |
| CADM1 | CADM1 | CADM1_CADM1 | CADM | GC | GC |
| CADM1 | CADM1 | CADM1_CADM1 | CADM | GC | Precancer |
| CADM3 | CADM3 | CADM3_CADM3 | CADM | GC | Precancer |
| CADM3 | CADM3 | CADM3_CADM3 | CADM | HNSCC | ADJ |
| CADM3 | CADM3 | CADM3_CADM3 | CADM | HNSCC | Healthy |
| CADM1 | CADM1 | CADM1_CADM1 | CADM | HNSCC | OSCC |
| CADM1 | CADM1 | CADM1_CADM1 | CADM | HNSCC | Precancer |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CAD | SNV | Missense_Mutation | c.2277G>A | p.Met759Ile | p.M759I | P27708 | protein_coding | deleterious(0) | benign(0.03) | TCGA-A2-A04W-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
| CAD | SNV | Missense_Mutation | novel | c.6202N>C | p.Gly2068Arg | p.G2068R | P27708 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A0T0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
| CAD | SNV | Missense_Mutation | novel | c.6203N>T | p.Gly2068Val | p.G2068V | P27708 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A2-A0T0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
| CAD | SNV | Missense_Mutation | c.6149N>A | p.Gly2050Glu | p.G2050E | P27708 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-A2-A0YD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
| CAD | SNV | Missense_Mutation | rs182811252 | c.5863N>T | p.Arg1955Trp | p.R1955W | P27708 | protein_coding | deleterious(0.02) | probably_damaging(0.949) | TCGA-A2-A1FX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
| CAD | SNV | Missense_Mutation | rs367846045 | c.6367N>A | p.Gly2123Ser | p.G2123S | P27708 | protein_coding | deleterious(0.03) | probably_damaging(0.94) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| CAD | SNV | Missense_Mutation | c.1333N>T | p.Gly445Trp | p.G445W | P27708 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AC-A23C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | chemo | CR | |
| CAD | SNV | Missense_Mutation | c.2977N>A | p.Glu993Lys | p.E993K | P27708 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| CAD | SNV | Missense_Mutation | novel | c.2888N>A | p.Arg963Gln | p.R963Q | P27708 | protein_coding | deleterious(0) | possibly_damaging(0.738) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| CAD | SNV | Missense_Mutation | c.1493N>T | p.Gly498Val | p.G498V | P27708 | protein_coding | deleterious(0) | benign(0.113) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |