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Gene: C6orf89 |
Gene summary for C6ORF89 |
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Gene information | Species | Human | Gene symbol | C6orf89 | Gene ID | 221477 |
Gene name | chromosome 6 open reading frame 89 | |
Gene Alias | BRAP | |
Cytomap | 6p21.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A0A024RCY0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
221477 | C6orf89 | P48T-E | Human | Esophagus | ESCC | 9.14e-12 | 2.60e-01 | 0.0959 |
221477 | C6orf89 | P49T-E | Human | Esophagus | ESCC | 2.44e-12 | 1.01e+00 | 0.1768 |
221477 | C6orf89 | P52T-E | Human | Esophagus | ESCC | 6.84e-20 | 5.03e-01 | 0.1555 |
221477 | C6orf89 | P54T-E | Human | Esophagus | ESCC | 8.00e-22 | 6.00e-01 | 0.0975 |
221477 | C6orf89 | P56T-E | Human | Esophagus | ESCC | 1.97e-11 | 9.11e-01 | 0.1613 |
221477 | C6orf89 | P57T-E | Human | Esophagus | ESCC | 3.09e-23 | 4.95e-01 | 0.0926 |
221477 | C6orf89 | P61T-E | Human | Esophagus | ESCC | 3.25e-21 | 4.88e-01 | 0.099 |
221477 | C6orf89 | P62T-E | Human | Esophagus | ESCC | 1.17e-45 | 7.73e-01 | 0.1302 |
221477 | C6orf89 | P65T-E | Human | Esophagus | ESCC | 2.47e-35 | 6.74e-01 | 0.0978 |
221477 | C6orf89 | P74T-E | Human | Esophagus | ESCC | 2.56e-39 | 9.56e-01 | 0.1479 |
221477 | C6orf89 | P75T-E | Human | Esophagus | ESCC | 3.37e-61 | 1.16e+00 | 0.1125 |
221477 | C6orf89 | P76T-E | Human | Esophagus | ESCC | 8.81e-39 | 4.90e-01 | 0.1207 |
221477 | C6orf89 | P79T-E | Human | Esophagus | ESCC | 4.38e-37 | 6.26e-01 | 0.1154 |
221477 | C6orf89 | P80T-E | Human | Esophagus | ESCC | 2.17e-35 | 1.15e+00 | 0.155 |
221477 | C6orf89 | P82T-E | Human | Esophagus | ESCC | 2.86e-23 | 1.11e+00 | 0.1072 |
221477 | C6orf89 | P83T-E | Human | Esophagus | ESCC | 1.05e-30 | 7.60e-01 | 0.1738 |
221477 | C6orf89 | P84T-E | Human | Esophagus | ESCC | 2.27e-14 | 6.64e-01 | 0.0933 |
221477 | C6orf89 | P89T-E | Human | Esophagus | ESCC | 1.53e-26 | 1.68e+00 | 0.1752 |
221477 | C6orf89 | P91T-E | Human | Esophagus | ESCC | 8.68e-18 | 1.53e+00 | 0.1828 |
221477 | C6orf89 | P107T-E | Human | Esophagus | ESCC | 6.36e-29 | 7.18e-01 | 0.171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:004578710 | Esophagus | ESCC | positive regulation of cell cycle | 196/8552 | 313/18723 | 9.27e-10 | 2.24e-08 | 196 |
GO:003105614 | Esophagus | ESCC | regulation of histone modification | 106/8552 | 152/18723 | 1.52e-09 | 3.55e-08 | 106 |
GO:00356015 | Esophagus | ESCC | protein deacylation | 79/8552 | 112/18723 | 8.30e-08 | 1.42e-06 | 79 |
GO:00987325 | Esophagus | ESCC | macromolecule deacylation | 80/8552 | 116/18723 | 3.19e-07 | 4.50e-06 | 80 |
GO:00165754 | Esophagus | ESCC | histone deacetylation | 60/8552 | 82/18723 | 3.85e-07 | 5.32e-06 | 60 |
GO:004206027 | Esophagus | ESCC | wound healing | 243/8552 | 422/18723 | 4.62e-07 | 6.25e-06 | 243 |
GO:00310583 | Esophagus | ESCC | positive regulation of histone modification | 65/8552 | 92/18723 | 1.04e-06 | 1.31e-05 | 65 |
GO:00064765 | Esophagus | ESCC | protein deacetylation | 70/8552 | 101/18723 | 1.29e-06 | 1.58e-05 | 70 |
GO:005067318 | Esophagus | ESCC | epithelial cell proliferation | 238/8552 | 437/18723 | 1.19e-04 | 8.20e-04 | 238 |
GO:00903122 | Esophagus | ESCC | positive regulation of protein deacetylation | 20/8552 | 25/18723 | 4.81e-04 | 2.69e-03 | 20 |
GO:00310652 | Esophagus | ESCC | positive regulation of histone deacetylation | 15/8552 | 19/18723 | 3.29e-03 | 1.35e-02 | 15 |
GO:00310631 | Esophagus | ESCC | regulation of histone deacetylation | 21/8552 | 31/18723 | 1.10e-02 | 3.70e-02 | 21 |
GO:00903114 | Esophagus | ESCC | regulation of protein deacetylation | 30/8552 | 48/18723 | 1.40e-02 | 4.57e-02 | 30 |
GO:004206012 | Liver | Cirrhotic | wound healing | 155/4634 | 422/18723 | 2.12e-08 | 7.56e-07 | 155 |
GO:001657011 | Liver | Cirrhotic | histone modification | 154/4634 | 463/18723 | 1.92e-05 | 2.57e-04 | 154 |
GO:003105611 | Liver | Cirrhotic | regulation of histone modification | 59/4634 | 152/18723 | 8.28e-05 | 9.02e-04 | 59 |
GO:00457874 | Liver | Cirrhotic | positive regulation of cell cycle | 97/4634 | 313/18723 | 6.88e-03 | 3.38e-02 | 97 |
GO:0035601 | Liver | Cirrhotic | protein deacylation | 39/4634 | 112/18723 | 1.08e-02 | 4.75e-02 | 39 |
GO:001657021 | Liver | HCC | histone modification | 283/7958 | 463/18723 | 2.68e-16 | 2.33e-14 | 283 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C6orf89 | SNV | Missense_Mutation | rs143348146 | c.748N>T | p.Arg250Cys | p.R250C | Q6UWU4 | protein_coding | deleterious(0) | possibly_damaging(0.736) | TCGA-A2-A0YJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD |
C6orf89 | SNV | Missense_Mutation | c.655N>A | p.Gly219Arg | p.G219R | Q6UWU4 | protein_coding | tolerated(0.08) | benign(0.441) | TCGA-AO-A124-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
C6orf89 | SNV | Missense_Mutation | c.772N>G | p.His258Asp | p.H258D | Q6UWU4 | protein_coding | tolerated(0.21) | benign(0.023) | TCGA-D8-A27F-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD | |
C6orf89 | SNV | Missense_Mutation | rs779924954 | c.218N>A | p.Ala73Glu | p.A73E | Q6UWU4 | protein_coding | deleterious(0) | benign(0.086) | TCGA-ZJ-AAXU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
C6orf89 | SNV | Missense_Mutation | c.353N>G | p.Ile118Ser | p.I118S | Q6UWU4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
C6orf89 | SNV | Missense_Mutation | rs79686273 | c.979N>A | p.Asp327Asn | p.D327N | Q6UWU4 | protein_coding | tolerated(0.85) | benign(0.001) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C6orf89 | SNV | Missense_Mutation | rs751486634 | c.923N>A | p.Arg308Gln | p.R308Q | Q6UWU4 | protein_coding | tolerated(0.33) | possibly_damaging(0.525) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C6orf89 | SNV | Missense_Mutation | rs571648523 | c.313N>T | p.Arg105Cys | p.R105C | Q6UWU4 | protein_coding | tolerated(0.13) | benign(0.007) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C6orf89 | SNV | Missense_Mutation | novel | c.664N>C | p.Ala222Pro | p.A222P | Q6UWU4 | protein_coding | tolerated(0.06) | benign(0.417) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C6orf89 | SNV | Missense_Mutation | novel | c.794N>T | p.Ala265Val | p.A265V | Q6UWU4 | protein_coding | tolerated(0.69) | benign(0.015) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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